Direct activation of toll-like receptor 4 signaling in group 2 innate lymphoid cells contributes to inflammatory responses of allergic diseases.

Group 2 innate lymphoid cells (ILC2s) are key players in type 2 immunity, but whether they can be directly activated by microbial ligands remain uncertain. In this study, we observed a positive correlation between blood endotoxin (LPS) levels and circulating ILC2s in allergic patients. , LPS robustly induced ILC2 proliferation and production of type 2 effector cytokines.

Fungal and enzymatic pretreatments of bamboo lignocellulose towards high-strength biocomposites: Biological macromolecule/enzyme interaction and bonding enhancement.

An energy-intensive and chemical-consuming pretreatment of bamboo is often required to develop its high-performance composites. This study is to evaluate a fungal and enzymatic pretreatment as a sustainable surface modification approach towards high-strength bamboo biocomposites based on D. sinicus.

A systematic review of the predictive value of radiomics for nasopharyngeal carcinoma prognosis.

Background: Radiomics has been widely used in the study of tumours, which has predictive and prognostic value in nasopharyngeal carcinoma (NPC). Therefore, we collected relevant literature to explore the role of current radiomics in predicting the prognosis of NPC.

Methods: We performed a systematic literature review and meta-analysis in accordance with the preferred reporting items in the systematic evaluation and meta-analysis guidelines.

Effect of Axial Clearance Variation on Dual-Rotor Flowmeter Performance.

This study examines the impact of axial clearance variations on the performance characteristics of a dual-rotor flowmeter (DRT-FM) through numerical simulations, with the validity of the numerical results verified by calibration experiments. The results indicate that within the range of 200 L/h to 1600 L/h, the K factors of different groups increase as clearance increases. The K factor of the 0.

A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses.

Humanized mice are limited in terms of modeling human immunity, particularly with regards to antibody responses. Here we constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated Kit mutant immunodeficient pups with human cord blood CD34 cells, followed by 17β-estradiol conditioning to promote immune cell differentiation. THX mice reconstitute a human lymphoid and myeloid immune system, including marginal zone B cells, germinal center B cells, follicular helper T cells and neutrophils, and develop well-formed lymph nodes and intestinal lymphoid tissue, including Peyer's patches, and human thymic epithelial cells.

Localization of the questionnaire about sharps disposal at home among diabetes based on knowledge, attitude, and practice theory, and a cross-sectional survey of current conditions.

Background: Diabetes Mellitus is a long duration disease, and if a person with diabetes is infected with a blood-borne infectious disease and proper syringe disposal practices are not followed, they run the danger of transmitting the infection to others for a very long period. Whereas fewer research has been done in China on the handing of sharp objects at home. Therefore, there is a need to translate and localize the Knowledge-Attitude-Practice Questionnaire regarding sharp disposal for diabetic patients to assess the current level of patient knowledge, attitudes, and practices and to improve the basis for promoting safe sharps handling practices.

Transceptor NRT1.1 and receptor-kinase QSK1 complex controls PM H-ATPase activity under low nitrate.

NRT1.1, a nitrate transceptor, plays an important role in nitrate binding, sensing, and nitrate-dependent lateral root (LR) morphology. However, little is known about NRT1.

Factors associated with quality of life among elderly patients with type 2 diabetes mellitus: the role of family caregivers.

Background: As a long-term chronic disease, Type 2 diabetes mellitus (T2DM) patients' quality of life is affected by both themselves and his/ her close relatives, requiring comprehensive support from family members to ensure that patients are able to manage disease. The objective of this study is to investigate the relationship between caregivers' sense of coherence, caregiver competence, and T2DM patients' quality of life, as well as to explore the factors affecting patients with T2DM patients.

Methods: This investigation was a cross-sectional study.

A lightweight mixup-based short texts clustering for contrastive learning.

Traditional text clustering based on distance struggles to distinguish between overlapping representations in medical data. By incorporating contrastive learning, the feature space can be optimized and applies mixup implicitly during the data augmentation phase to reduce computational burden. Medical case text is prevalent in everyday life, and clustering is a fundamental method of identifying major categories of conditions within vast amounts of unlabeled text.

Melittin alleviates sepsis-induced acute kidney injury by promoting GPX4 expression to inhibit ferroptosis.

Objectives: Melittin, the main component of bee venom, is a natural anti-inflammatory substance, in addition to its ability to fight cancer, antiviral, and useful in diabetes treatment. This study seeks to determine whether melittin can protect renal tissue from sepsis-induced damage by preventing ferroptosis and explore the protective mechanism.

Methods: In this study, we investigated the specific protective mechanism of melittin against sepsis-induced renal injury by screening renal injury indicators and ferroptosis -related molecules and markers in animal and cellular models of sepsis.

Neighborhood effects on the health of elderly persons: evidence from China.

Background: Presently, global aging has become increasingly serious, whereas the health concerns brought by aging have become a public issue that warrants an urgent solution from all countries across the world. Therefore, this research paper discusses the influence of neighborhood health on elderly individuals' health, and extending a realistic basis for the other economies to improve the neighborhood environment and promote the health of the elderly.

Methods: Based on the data of CHARLS2018, this research paper adopts the samples that fulfill the study requirements (N = 7326).

Psychological resilience and work engagement of Chinese nurses: a chain mediating model of career identity and quality of work life.

Aim: To investigate how nurses' psychological resilience affects their work engagement and the resulting pathways, namely, the intermediary effect of career identity and quality of work life.

Background: Psychological resilience is the ability to adapt to new circumstances and overcome difficulties. Work engagement is a positive, perfect emotional and cognitive state in the work process, which has a positive effect on nurses' physical and mental health and career development.

LPN: Label-Enhanced Prototypical Network for Legal Judgment Prediction.

As one of the most critical tasks in legal artificial intelligence, legal judgment prediction (LJP) has garnered growing attention, especially in the civil law system. However, current methods often overlook the challenge of imbalanced label distributions, treating each label with equal importance, which can lead the model to be biased toward labels with high frequency. In this paper, we propose a label-enhanced prototypical network (LPN) suitable for LJP, that adopts a strategy of uniform encoding and separate decoding.

Multi-task learning for arousal and sleep stage detection using fully convolutional networks.

Sleep is a critical physiological process that plays a vital role in maintaining physical and mental health. Accurate detection of arousals and sleep stages is essential for the diagnosis of sleep disorders, as frequent and excessive occurrences of arousals disrupt sleep stage patterns and lead to poor sleep quality, negatively impacting physical and mental health. Polysomnography is a traditional method for arousal and sleep stage detection that is time-consuming and prone to high variability among experts.

Construction of cardiovascular information extraction corpus based on electronic medical records.

Cardiovascular disease has a significant impact on both society and patients, making it necessary to conduct knowledge-based research such as research that utilizes knowledge graphs and automated question answering. However, the existing research on corpus construction for cardiovascular disease is relatively limited, which has hindered further knowledge-based research on this disease. Electronic medical records contain patient data that span the entire diagnosis and treatment process and include a large amount of reliable medical information.

Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells.

Maturation of antibody responses entails somatic hypermutation (SHM), class-switch DNA recombination (CSR), plasma cell differentiation, and generation of memory B cells, and it is thought to require T cell help. We showed that B cell Toll-like receptor 4 (TLR4)-B cell receptor (BCR) (receptor for antigen) coengagement by 4-hydroxy-3-nitrophenyl acetyl (NP)-lipopolysaccharide (LPS) ( lipid A polysaccharide O-antigen) or TLR5-BCR coengagement by flagellin induces mature antibody responses to NP and flagellin in βδ and NSG/B mice. TLR-BCR coengagement required linkage of TLR and BCR ligands, "linked coengagement.

SnO-Based Ultra-Flexible Humidity/Respiratory Sensor for Analysis of Human Breath.

Developing ultraflexible sensors using metal oxides is challenging due to the high-temperature annealing step in the fabrication process. Here, we demonstrate the ultraflexible relative humidity (RH) sensor on food plastic wrap by using 808 nm near-infrared (NIR) laser annealing for 1 min at a low temperature (26.2-40.

The positive impact of informal spousal caregiving on the physical activity of older adults.

Introduction: Although physical activity (PA) is crucial for health, the literature is mixed about how individuals' PA decisions are affected by their spouses. To fill this gap, we examined the extent to which providing care for one spouse affects the PA of the other spouse among those aged 50 or older in the United States.

Methods: We analyzed 9,173 older adults living with their spouses or partners from the 2004 to 2016 waves of the Health and Retirement Study.

Effects of ITO Contact Sizes on Performance of Blue Light MicroLEDs.

In this study, the effect of ITO contact ratio for blue light micro-light-emitting diode (µLED) with dimensions 40 μm × 40 μm was assessed. The contact ratio from 0.2 to 0.

Facile Fabrication of a Bio-Inspired Leaf Vein-Based Ultra-Sensitive Humidity Sensor with a Hygroscopic Polymer.

Bio-inspired materials have received significant interest in the development of flexible electronics due to their natural grid structures, especially natural leaf vein networks. In this work, a bio-inspired leaf vein-based flexible humidity sensor is demonstrated. The proposed sensor is composed of a leaf/Al/glycerin/Ag paste.

Sensitive fluorescence biosensor for SARS-CoV-2 nucleocapsid protein detection in cold-chain food products based on DNA circuit and g-CNQDs@Zn-MOF.

SARS-CoV-2 isolation from cold-chain food products confirms the possibility of outbreaks through cold-chain food products. RNA extraction combined with RT-PCR is the primary method currently utilized for the detection of SARS-CoV-2. However, the requirement of hours of analytical time and the high price of RT-PCR hinder its worldwide implementation in food supervision.

Application of cascade binary pointer tagging in joint entity and relation extraction of Chinese medical text.

Extracting relational triples from unstructured medical texts can provide a basis for the construction of large-scale medical knowledge graphs. The cascade binary pointer tagging network (CBPTN) shows excellent performance in the joint entity and relation extraction, so we try to explore its effectiveness in the joint entity and relation extraction of Chinese medical texts. In this paper, we propose two models based on the CBPTN: CBPTN with conditional layer normalization (Cas-CLN) and biaffine transformation-based CBPTN with multi-head selection (BTCAMS).

Cross-Activation of Hemichannels/Gap Junctions and Immunoglobulin-Like Domains in Innate-Adaptive Immune Responses.

Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate-adaptive immune response independently. Despite of available evidence demonstrating the importance of HCs/GJs and IGLDCPs in initiating, implementing, and terminating the entire immune response, our understanding of their mutual interactions in immunological function remains rudimentary. IGLDCPs include immune checkpoint molecules of the immunoglobulin family expressed in T and B lymphocytes, most of which are cluster of differentiation (CD) antigens.