[Effect of the transcranial electrical stimulation of the endorphinergic brain structures on the functional activity of hepatocytes after toxic exposure].

Biochemical events of the rat hepatocytes cytolysis and deterioration of their synthetic activity and detoxification ability, as well as morphological events of lipid degeneration after acute poisoning with dichloretane and CCl4, were significantly reduced by effects of transcranial stimulation (TES). Blockade of the TES effects with naloxone revealed its endorphinergic nature. Combined effects of the TES and Essenciale preparation were lower than separate those of these agents.

[The effect of administering corticoliberin into the striatum on the open-field and shuttle-box behaviors of KHA and KLA strain rats].

The effects of corticotropin-releasing hormone (CRH) injected into the dorsal neostriatum on the open-field and shuttle-box behavior were studied in rats with high (Koltushi high avoidance, KHA) and low (Koltushi low avoidance, KLA) capability for avoidance learning. The effects of this hormone on the behavior of these rat strains were different. In KLA rats with passive strategy of behavior the CRH injection led to a rapid locomotor activation in the open field, while the rats with active behavioral strategy (KHA) reacted to the injection by a significant decrease in locomotion and change for the passive mode of behavior.

[Phospholipid and malondialdehyde content in the cerebral cortex of rats with incomplete ischemia and in the postischemic period].

During severe incomplete brain ischemia caused by combined bilateral ligation of the general carotid arteries and blood pressure reduction to 50 Hg by blood withdrawal from the femoral artery, the cortex of cerebral hemispheres demonstrates, by the 60th minute of ischemia, a 15.4%-lowering of the content of total phospholipids (PL) and a 33.3%-increase in the content of malonyl dialdehyde (MDA).

[Effect of cerebral blood supply disorders on certain aspects of metabolism].

Bilateral ligation of common carotid arteries sharply decreases volume blood flow and oxygen consumption in the cortex, in diencephalon and midbrain whereas inducing no changes in the cerebellum and medulla oblongata. The same is true for intensity of metabolism of both total and separate fractions of phospholipids. This suggests that the changes of phospholipid metabolism in neural tissue depend on the degree of its blood supply disturbance and duration of the ischemia.

[Restoration of blood supply and the intensity of phospholipid metabolism in different rat brain regions during the postischemic period].

Fifteen min after resumption of the blood flow in the common carotid arteries the arrest of which was caused by ligation, a considerable intensification of the blood supply in the hemispheres, diencephalon and the midbrain and its simultaneous reduction in the cerebellum and the medulla oblongata occurred. Sixty min later the cerebral blood supply in all the parts of the brain under study recovered completely, except the hemispheres. The complete postischemic recovery of the phospholipid metabolism intensity occurred in the brain regions showing a considerable diminution of the phospholipid metabolism during the ischemic period.

[Effect of cerebral ischemia on the metabolism of individual lipid fractions].

Ninety minutes after ligation of common carotid arteries a decrease of the metabolism intensity both of the total phospholipids (PL) and of their different fractions was nearly the same. In the diencephalon reduction of the metabolic rate of the total PL was accounted for by metabolic depression of phosphatidylcholine and phosphoinositide fractions only.

[Relationship between the phospholipid metabolism of different portions of rat brain and the degree of circulatory disruption in them (following carotid artery ligation)].

Bilateral ligation of common carotid arteries in rats caused a considerable reduction of the blood supply and also a marked fall of phospholipids (PL) metabolism in the hemispheres; in the diencephalon and the midbrain it occurred to a lesser degree; there were no alterations in the blood supply or the PL metabolism in the medulla oblongata and the cerebellum. Dependence of the extent of depression of the PL metabolism on the degree of blood supply disturbances varied in different brain regions. Even 5 hours after the ligation of both carotid arteries there was no restoration of blood supply.