Int J Cardiol Heart Vasc
February 2025
Introduction: Antimicrobial resistance (AMR) is a global health crisis that is predicted to worsen in the coming years. While improper antibiotic usage is an established driver, less is known about the impact of other endogenous and exogeneous environmental factors, such as metals, on AMR. One metal of interest is zinc as it is often used as a supplement for diarrhea treatment prior to antibiotics.
View Article and Find Full Text PDFMammals, being social creatures communicate through a variety of signal cues, thus it is vital to understand how wild carnivores create and maintain connections with their neighbors for their survival. However, observing elusive species in their natural habitats poses significant challenges leading to scarcities of data. In this study, we aimed to provide a detailed long-term observation of snow leopards in the northern region of Pakistan, hence we utilized data from 136 camera traps between 2018 and 2023 in order to investigate the territorial marking behavior of snow leopards in Baltistan.
View Article and Find Full Text PDFThe case-control study was planned to determine if an educational intervention tool could reduce coronavirus disease-2019 vaccine hesitance and resistance in people visiting a tertiary care hospital in a developing country. Participants were randomly enrolled into intervention group A and control group B from July to December 2021. Participants in group A reviewed an educational intervention tool prior to completing a questionnaire, while participants in group B did not.
View Article and Find Full Text PDFConventional drug delivery systems often suffer from non-specific distribution and limited therapeutic efficacy, leading to significant side effects. To address these challenges, we developed magnetoelectric, cobalt ferrite@barium titanate (CFO@BTO) nanofibers (NFs), with a core-shell structure for targeted anticancer drug delivery. The electrospinning method was employed to synthesize polymeric NFs based on magnetoelectric core-shell nanostructures.
View Article and Find Full Text PDFExpert Rev Clin Pharmacol
November 2024
Maackiain is an important component of some herbs in traditional Chinese medicine (TCM), such as Sophora flavescens Aiton, Spatholobus suberectus Dunn and Paeonia lactiflora Pall. Maackiain belongs to the second largest group of isoflavonoids the pterocarpans that is widespread in several plant genera, for example Maackia, Sophora, Caragana, Trifolium and Millettia. Recently, maackiain has attracting more attention because of its numerous pharmacological properties.
View Article and Find Full Text PDFIntroduction: Mixed hyperlipidemia represents a substantial public health issue and a considerable burden on healthcare systems. Although the introduction of statins and LDL-cholesterol lowering agents have significantly reduced the incidence of atherosclerotic cardiovascular diseases (ASCVD), a significant portion of the population continues to exhibit ASCVD progression due to elevated triglyceride-rich lipoprotein (TRL) levels. This persistent risk has catalyzed the development of novel pharmacological interventions targeting these lipoproteins.
View Article and Find Full Text PDFAntimicrobial resistance (AMR) is a major threat to global health and resistant bacterial populations have been observed to develop and spread in and around wastewater. However, studies on AMR development are typically conducted in ideal media conditions which can differ in composition and nutrient density from wastewater. In this study, we compare the growth and AMR development of in standard LB broth to a synthetic wastewater recipe and autoclaved wastewater samples from the Massachusetts Water Resources Authority (MWRA).
View Article and Find Full Text PDFAfter COVID-19, a turning point in the way of pharmaceutical technology is gene therapy with beneficial potential to start a new medical era. However, commercialization of such pharmaceuticals would never be possible without the help of nanotechnology. Nanomedicine can fulfill the growing needs linked to safety, efficiency, and site-specific targeted delivery of Gene therapy-based pharmaceuticals.
View Article and Find Full Text PDFNoninvasive and invasive imaging modalities play important roles for the detection of patent foramen ovale (PFO). Transthoracic echocardiography or transcranial Doppler bubble study can be used for initial noninvasive PFO screening. For diagnostic confirmation, transesophageal echocardiography bubble study can be utilized, a semiinvasive confirmatory test that can directly visualize a PFO.
View Article and Find Full Text PDF5-methyl-2-hexanone is used as a versatile polymerization solvent for industrial preparation processes of bulk and fine chemicals. An efficient catalyst, Pd/γ-AlO, is reported for the preparation of 5-methyl-2-hexanone by selective hydrogenation of 5-methyl-3-hexen-2-one. The catalyst exhibits remarkable activity and selectivity even at atmospheric pressure and low temperature (1 atm, 80 °C).
View Article and Find Full Text PDF(also known as nowadays), quite different from its genus,is a facultatively anaerobic organism that rarely causes human infections.Like the rest of its genus, it usually has a good prognosis. In this case report, we present an interesting case of a middle-aged female who presented to the emergency department (ED) with fever and dyspnea, eventually diagnosed with infective endocarditis (IE) caused by To the best of our knowledge, it is the first reported case of causing right-sided infective endocarditis in a middle-aged female with no residual or prosthetic valvular disease.
View Article and Find Full Text PDFIntroduction Atrial fibrillation (AF) is a major global health concern, and early prediction is essential for managing high-risk individuals. N-terminal prohormone of brain natriuretic peptide (NT-proBNP) has emerged as a crucial biomarker for predicting AF. While most studies have concentrated on cohorts already diagnosed with AF or other cardiac diseases, this research investigates the predictive value of NT-proBNP for AF development in a population without prior AF diagnosis.
View Article and Find Full Text PDFObjectives: Identifying key barriers to accessing quality-assured and affordable antimicrobials among forcibly displaced persons in Uganda, Yemen and Colombia and investigating their (1) utilisation patterns of antibiotics, (2) knowledge about antimicrobial resistance (AMR) and (3) perception of the quality of antimicrobials received.
Design: Pilot cross-sectional survey.
Setting: Data were collected from five health facilities in the Kiryandongo refugee settlement (Bweyale, Uganda), three camps for internally displaced persons (IDPs) in the Dar Sad district (Aden, Yemen) and a district with a high population of Venezuelan migrants (Kennedy district, Bogotá, Colombia).
Antibiotics (Basel)
May 2024
The aim of this paper is to explore and assess various strategies for monitoring antimicrobial consumption (AMC) in animals, within the context of the One Health approach. Recent studies have shed light on the limited surveillance and data collection for AMC in animals. Using the United States Center for Disease Control and Prevention Policy Analytical Framework, we assess global, national, and farm-level surveillance strategies on public health impact and feasibility using evidence from primary, secondary, and grey literature.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
November 2024
Areas of the body accessible to gastric secretions, such as the stomach and duodenum, are most commonly damaged by circumscribed lesions of the upper gastrointestinal tract mucosa. Peptic ulcer disease is the term for this illness (PUD). About 80% of peptic ulcers are duodenal ulcers, with stomach ulcers accounting for the remaining 20%.
View Article and Find Full Text PDFIn the original publication, there was a mistake in one author name, Mohammed Alasmari should be Mohammed S [...
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