Essential oil based controlled-release non-toxic evaporating tablet provides effective repellency against Musca domestica.

Housefly, Musca (M) domestica L. (Diptera: Muscidae) is a pervasive insect that transmits a variety of pathogens to humans and livestock. Although numerous synthetic pesticides are available to combat houseflies, their ecological and toxicological concerns have led to the exploration of natural products as safer alternatives.

Social and administrative issues related to the COVID-19 pandemic in Pakistan: better late than never.

The study critically reviewed Pakistan's provincial updates of coronavirus disease 2019 (COVID-19) and discussed the current challenges faced by the government in a given context. The coronavirus-associated death tolls have been increasing rapidly in a country. The provincial status of confirmed cases of coronavirus is higher in Punjab, followed by the Sindh, Khyber Pakhtunkhwa (KPK), and Balochistan.

Impact of average temperature, energy demand, sectoral value added, and population growth on water resource quality and mortality rate: it is time to stop waiting around.

It is an overwhelming concern that increases in global average temperature lead to serious consequences on the natural environment in the form of deteriorating water resource quality and damaging healthcare sustainability agenda. The sustainable innovation forum (COP21) shows a high concern on climate changes and suggested to reduce global average temperature less than 2 °C. The study brings an idea from the stated theme and analyzed the relationship between climate change and water resource quality in order to redesign economic and environmental policies to improve water quality and healthcare sustainability in the context of Pakistan.

Use of Typhoid Vi-Polysaccharide Vaccine as a Vaccine Probe to Delineate Clinical Criteria for Typhoid Fever.

Blood cultures (BCs) detect an estimated 50% of typhoid fever cases. There is need for validated clinical criteria to define cases that are BC negative, both to help direct empiric antibiotic treatment and to better evaluate the magnitude of protection conferred by typhoid vaccines. To derive and validate a clinical rule for defining BC-negative typhoid fever, we assessed, in a cluster-randomized effectiveness trial of Vi-polysaccharide (ViPS) typhoid vaccine in Kolkata, India, 14,797 episodes of fever lasting at least 3 days during 4 years of comprehensive, BC-based surveillance of 70,865 persons.

Antibacterial and NF-κB Inhibitory Lumazine Peptides, Aspochalasin, γ-Butyrolactone Derivatives, and Cyclic Peptides from a Hawaiian .

Five new lumazine peptides (-), a new aspochalasin derivative (), and a new γ-butyrolactone derivative (), together with seven known compounds (-), were isolated from a Hawaiian fungal strain, FS888. Compound is an uncommon natural product containing an isocyano group. The structures of the new compounds - were elucidated by NMR spectroscopy, HRESIMS, chemical derivatization, and ECD analysis.

Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies.

Background: The inhibition of α-amylase enzyme is one of the best therapeutic approach for the management of type II diabetes mellitus. Chalcone possesses a wide range of biological activities.

Objective: In the current study chalcone derivatives (1-16) were synthesized and evaluated their inhibitory potential against α-amylase enzyme.

Design, development and assessment of an essential oil based slow release vaporizer against mosquitoes.

Mosquitoes (Diptera; Culicidae) are a biting nuisance and are of economic and health importance, especially for people living in tropical countries like India. Given the environmental concerns and health hazards of synthetic insecticides, development of natural products for the control of mosquito and mosquito-borne diseases are needed. In view of this, an essential oil based novel liquid vaporizer formulation with citronella and eucalyptus oils has been developed using a computer aided Artificial Neural Network and Particle Swarm Optimization (ANN-PSO) algorithm approach, aiming to predict the best optimized formulation (OF).

Relationship between population growth, price level, poverty incidence, and carbon emissions in a panel of 98 countries.

The objective of the study is to examine the dynamic linkages between population growth, price level, poverty headcount ratio, and carbon emissions under investigation of different plausible hypothesis, including "population-induced poverty trap," "welfare-reducing effects," "environmental Kuznets curve," and "pollution haven" hypotheses in the cross-sectional setting of 98 developed and developing countries for the period of 2011. The study used cross-sectional regression and switching regression regime for empirical analysis. The result shows a positive relationship between changes in price level and carbon emissions that verify "welfare-reducing effects," while there is a negative relationship between population growth and poverty at varying poverty threshold to support the "Gary Becker human capital theory.

[Breast cancer: perspectives from integrative medicine].

Integrative medicine combines the virtues of conventional medicine and complementary medicine in order to improve the quality of life of patients suffering from cancer. Thanks to a multidisciplinary and multi-professional team, the Center for integrative and complementary medicine (CEMIC) allows since 2017 cancer patients at CHUV to have access to certain therapies, for which there are sufficient data suggesting a benefit in terms of quality of life. The concepts of tolerance, safety, risk of interactions and potential adverse biological effects remain central.

Retina-Targeted Delivery of 17β-Estradiol by the Topically Applied DHED Prodrug.

The purpose of this study was to explore retina-targeted delivery of 17β-estradiol (E2), a powerful neuroprotectant, by its bioprecursor prodrug 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) administered as eye drops in animal models. Compared to the parent hormone, DHED displayed increased transcorneal flux ex vivo both with and without the presence of 2-hydroxypropyl-β-cyclodextrin used as a penetration-enhancing excipient in rat, rabbit, and pig. In vitro, the prodrug also showed facile bioactivation to E2 in the retina but not in the cornea.

Does communicable diseases (including COVID-19) may increase global poverty risk? A cloud on the horizon.

Coronavirus epidemic can push millions of people in poverty. The shortage of healthcare resources, lack of sanitation, and population compactness leads to an increase in communicable diseases, which may increase millions of people add in a vicious cycle of poverty. The study used the number of factors that affect poverty incidence in a panel of 76 countries for a period of 2010-2019.

Cardiovascular safety of rapidly accelerated fibrosarcoma B-type and/or mitogen-activated extracellular signal-regulated kinase inhibitors: A mixed approach combining a meta-analysis and a pharmacovigilance disproportionality analysis.

Background: The risk of cardiovascular adverse events from rapidly accelerated fibrosarcoma B-type (BRAF) and mitogen-activated extracellular signal-regulated kinase (MEK) inhibitors is not fully characterized.

Aim: To evaluate the cardiovascular adverse events risks related to BRAF and/or MEK inhibitors in randomized placebo-controlled clinical trials and in the real-life setting.

Methods: We used two approaches.

Relationship between energy demand, financial development, and carbon emissions in a panel of 101 countries: "go the extra mile" for sustainable development.

The objective of the study is to examine the impact of energy demand on carbon emissions in mediation of financial development and economic growth in a panel of 101 countries by using the time series data from 1995 to 2018. The study employed dynamic GMM estimator in order to reduce possible endogeneity in the given model. Further, the study used Granger causality and innovation accounting matrix (IAM) to find the causal relationships and variance error shocks between the variables.

Sequelae Following Acute Encephalitis Syndrome Caused by Orientia Tsutsugamushi.

We evaluated 146 patients with acute encephalitis syndrome caused by Orientia tsutsugamushi, after median interval of 5 months of hospitalization, to estimate the proportion and spectrum of disability. Fifty-six (38.4%) had mild, whereas 19 (13%) had moderate to severe degree of disability.

Evaluation of antioxidant and antimicrobial activities on various extracts of Himalayan medicinal plants.

The DPPH radical scavenging potentials of the fractions were determined in comparison to positive controls such as quercetin with EC = 4.12±1.27, ascorbic acid with EC = 6.

Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial.

Background: Few options exist for treatment of patients with small-cell lung cancer (SCLC) after failure of first-line therapy. Lurbinectedin is a selective inhibitor of oncogenic transcription. In this phase 2 study, we evaluated the acti and safety of lurbinectedin in patients with SCLC after failure of platinum-based chemotherapy.

Effectiveness of Presumptive Treatment of Acute Febrile Illness With Doxycycline or Azithromycin in Preventing Acute Encephalitis Syndrome in Gorakhpur, India: A Cohort Study.

Objective: To estimate effectiveness of presumptive doxycycline or azithromycin treatment in preventing progression of Acute Febrile Illness to Acute Encephalitis Syndrome in Gorakhpur.

Study Design: Prospective cohort study.

Study Setting: Primary healthcare centers and Community healthcare centers of Gorakhpur district, Uttar Pradesh.

Successful Treatment of Well-Developed Accessory Lower Limb Associated with Spinal Dysraphism.

Accessory lower limb with spinal dysraphism are amongst the rarest known anomalies. We successfully managed a 5-months old female infant with surgical ablation of the accessory lower limb and repair of the associated large lipomyelomeningocele. A comprehensive review of the relevant literature was undertaken and presented herein.

Out-of-Sequence Vaccinations With Measles Vaccine and Diphtheria-Tetanus-Pertussis Vaccine: A Reanalysis of Demographic Surveillance Data From Rural Bangladesh.

Background: Due to delays in vaccinations, diphtheria-tetanus-whole-cell-pertussis (DTP) is often given with or after measles vaccine (MV)-out of sequence. We reanalyzed data from Matlab, Bangladesh, to examine how administration of MV and DTP out-of-sequence was associated with child survival.

Methods: In sum, 36 650 children born between 1986 and 1999 were followed with registration of vaccinations and survival.

Prevalence of Self-medication for Acid Peptic Disease amongst People of Manawa, Lahore.

Introduction Acid peptic disease is a common disorder, affecting millions of people worldwide. Its pharmacological management includes proton pump inhibitors, H blockers, antacids and mucosal protective agents. Multiple studies in Pakistan have shown increased tendency of population for self-medication.

NF-κB Inhibitory and Antibacterial Helvolic and Fumagillin Derivatives from .

Two new helvolic acid analogues ( and ) and one new fumagillin derivative containing an octahydroisobenzofuran moiety (), together with four known compounds (-), were isolated from an , isolated from soil collected from Mauna Kea, the highest mountain in Hawaii. Compound was recorded in SciFinder with a CAS Registry Number of 1379525-35-5, but it was not documented in the cited reference (. , , 137).

Molecular confirmation & characterization of in north India: A report of three cases.

Background & Objectives: In India, spotted fever group rickettsiae (SFGR) are an underdiagnosed cause of acute febrile illness (AFI). The non-specific Weil-Felix test is the first diagnostic modality for the diagnosis of SFGR in many laboratories due to the lack of advanced diagnostic facilities in developing countries. The aim of this study was to detect SFGR using molecular methods in the patients, presenting with AFI in a tertiary care centre in north India.

Innate inflammatory response to acute inhalation exposure of riot control agent oleoresin capsicum in female rats: An interplay between neutrophil mobilization and inflammatory markers.

The use of oleoresin capsicum (OC) sprays, due to their irreversible health effects has now grown into a matter of heated debate. In the present study, the early phase pulmonary events involving chemotactic and inflammatory mediators after short-exposure duration to OC have been presented. Female Wistar rats used in the evaluation of respiratory parameters at 1 h, 3 h, and 24 h post-exposure, were sacrificed for the evaluation of blood cell counts, BALF cytokine estimation, lung capillary leakage, study of oxidative stress and histopathology of the lungs.