Pharmacokinetics of cyclosporine as a function of energy--protein deficiency in children with chronic renal failure.

The present study was conducted to determine whether malnutrition in patients with chronic renal failure requiring cyclosporine therapy for renal transplantation has some effect on the clinical pharmacokinetics of cyclosporine. Eleven pediatric patients were enrolled in this study before renal transplantation and divided into two groups (group I: six well-nourished patients with a deficit in weight/height ratio < or = 7%; group II: five malnourished patients with a deficit in weight/height > 8%). The patients received a single oral dose of cyclosporine (3.

[Chemico-clinical permanent program of the NIH. I. The first phase of the program].

Background Information: This is the report of the first phase of an internal/external permanent program of the MNIH (Mexican National Institutes of Health). The permanent program evolved from a previous one operating from 1984 to 1988 in the MNIH (Refs 1-5).

Objective: To evaluate the precision of the assay systems used currently by the clinical chemistry laboratories of the MNIH.

Idiopathic gastroparesis in patients with unexplained nausea and vomiting.

Nausea and vomiting are symptoms sometimes associated with motor dysfunction. We compared a group of young patients suffering from chronic nausea and/or vomiting and normal upper gastrointestinal x-ray series with a control group. The members of both groups underwent isotopic examinations of their stomachs.

Stress fractures of the femoral neck following strenuous activity.

Stress fractures of the femoral neck following sustained strenuous physical activity are uncommon. In 194 military recruits in elite basic training who had sustained 257 stress fractures, most of them in long bone diaphyses, nine such fractures were located in the femoral neck. Seven of these fractures were transverse and undisplaced, and were treated successfully by bed rest and non-weight bearing for 6-8 weeks.

High ligation or embolization of varicocele.

The presence of a varicocele was confirmed in 121 of 123 patients complaining of scrotal pain or infertility, in whom radionuclide scanning was performed. In the first 29 patients (retrospective study), a high ligation of the internal spermatic vein was performed. In 94 patients, a percutaneous venography was done via the jugular vein followed by embolization by Gianturco coils (occluding spring embolus, Cook Group Company, USA) in 84 of them.

Differential diagnosis between Kaposi's sarcoma and pseudo-Kaposi's arteriovenous malformation by scintigraphy.

Kaposi's sarcoma and pseudo-Kaposi's arteriovenous malformation differ greatly in cause, evolution, prognosis, and treatment; yet their clinical macroscopic manifestations are similar. A simple and safe method of distinguishing between them is described.

Dynamic, diagnostic, and pharmacological radionuclide studies of the esophagus in achalasia.

The esophagus was evaluated in 15 patients with achalasia by continuous gamma camera imaging following ingestion of a semi-solid meal labeled with 99mTc. The images were displayed and recorded on a simple computerized data processing/display system. Subsequent ciné mode images of esophageal emptying demonstrated abnormalities of the body of the esophagus not reflected by the manometric examination.

Exposure to radioiodine in the preconception and conception periods. A case report.

A case of radiation exposure shortly before conception is presented. The patient refused abortion and was delivered of a healthy infant. On reconsideration of the case, it was decided that the recommendation to terminate the pregnancy on the grounds of excessive exposure to radiation was unjustified.

Sequential use of technetium 99m MDP and gallium 67 citrate imaging in the evaluation of painful total hip replacement.

Fourteen patients with 20 total hip joint replacements were studied for 14 painful prosthetic hips. Clinical examination, plain film radiographs and 99Tcm-MDP bone scans failed to differentiate between infection and mechanical loosening of a prosthesis. Sequential use of 99Tcm-MDP and 67Ga-citrate bone scans were performed in an attempt to discover underlying infectious process.