Publications by authors named "Zalman Wong"
Article Synopsis
- - Oligodendroglioma tumors are defined by specific mutations (IDH1/IDH2) and genetic deletions (1p/19q), with altered metabolism leading to increased levels of monounsaturated fatty acids and ceramides, promoting cell death.
- - The study reveals that inhibiting an enzyme called acid ceramidase (AC) can trigger apoptosis in IDH1 oligodendroglioma cells, enhancing survival rates in mice models.
- - The treatment with a drug named SABRAC showed significant effectiveness in causing cancer cell death by increasing ceramide levels, indicating a strong potential for AC as a target for future oligodendroglioma therapies.
