Acute Infusion-Related Side Effects of Amphotericin B Lipid Complex (ABLC) in Oncohematological Patients: Real-World Data from Brazilian Reference Centers.

Introduction: Amphotericin B lipid complex (ABLC) is an effective antifungal agent for treating invasive fungal infections (IFIs) even though its formulation is associated with potential adverse events, including those related to its infusion. This study aimed to analyze the incidence of acute infusion-related side effects (IRSE) associated with ABLC and their relationship with the profile of patients with oncohematological disease admitted in Brazilian reference tertiary hospitals.

Methods: This is an observational retrospective study that included clinical records of patients hospitalized, in a period of 6 years, diagnosed with probable or proved IFI and treated with at least two doses of ABLC.

Effect of the Application of Sunflower Biochar and Leafy Trees Biochar on Soil Hydrological Properties of Fallow Soils and under Soybean Cultivation.

Soils enriched with biochar are recommended as a cultivation grounds, especially in case they contain significant amount of sand. However, the interactions between biochar and plants, as well as the influence of the biochar on water retention, cultivation and air properties of soils, are still not obvious. The present study aimed to determine the impact of various biochar doses on soils used for soya cultivation, in comparison to soils maintained as black fallow soil, on their water retention and productivity, for the period of two years.

Evaluation of pain and opioid consumption in local preemptive anesthesia and the erector spine plane block in thoracoscopic surgery: A randomized clinical trial.

Objective: assess pain and opioid consumption in patients undergoing anesthetic techniques of spinal erector plane block and local anesthetic block in video-assisted thoracic surgery in the immediate postoperative period.

Methods: ninety-two patients undergoing video assisted thoracic surgery were randomized to receive ESPB or BAL before starting the surgical procedure. Using the numerical verbal scale, the primary outcome assessed was the patient's pain in the immediate postoperative period (POI).

Sertraline repositioning: an overview of its potential use as a chemotherapeutic agent after four decades of tumor reversal studies.

Sertraline hydrochloride is a first-line antidepressant with potential antineoplastic properties because of its structural similarity with other drugs capable to inhibit the translation-controlled tumor protein (TCTP), a biomolecule involved in cell proliferation. Recent studies suggest it could be repositioned for cancer treatment. In this review, we systematically map the findings that repurpose sertraline as an antitumoral agent, including the mechanisms of action that support this hypotesis.

Effect of heat stress on the antioxidant defense system and erythrocyte morphology of Antarctic fishes.

This study analyzed the effect of thermal stress on erythrocytes of Notothenia rossii and Notothenia coriiceps, abundant notothenioids in Admiralty Bay, Antarctic Peninsula. In both species, the antioxidant defense system enzymes, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S transferase, glutathione reductase were punctually altered (8°C for 1, 3 and 6 days) in erythrocytes, indicating that these markers are not ideal for termal stress. However, under the influence of thermal stress, morphological changes in Notothenia coriiceps erythrocytes were observed at all exposure times (1, 3 and 6 days at 8°C), and in Notothenia rossii occurred in 6 days.

Chemotherapy in focus: A meta-analysis confronts immunotherapy in the treatment of advanced melanoma.

This study aimed to analyze the efficacy of the monoclonal antibodies ipilimumab, nivolumab, and pembrolizumab when compared with conventional chemotherapy in the treatment of advanced melanoma. Three authors made the search independently and five articles matched the eligibility criteria. A fourth expert confirmed their quality (κ = 1).

Effect of long-term thermal challenge on the Antarctic notothenioid Notothenia rossii.

The thermal stability of the Antarctic Ocean raises questions concerning the metabolic plasticity of Antarctic notothenioids to changes in the environmental temperature. In this study, Notothenia rossii survived 90 days at 8 °C, and their condition factor level was maintained. However, their hepatosomatic (0.

Metabolic responses in Antarctic Nototheniidae brains subjected to thermal stress.

Antarctic Nototheniidae is an attractive group for studying metabolic and physiological responses at high temperatures. The present work investigated the metabolic responses of the carbohydrate metabolism and antioxidant system to thermal stress at 8 °C (for 2-144 h) in the brains of Notothenia rossii and Notothenia coriiceps. In N.

Pollution indices as useful tools for the comprehensive evaluation of the degree of soil contamination-A review.

The paper provides a complex, critical assessment of heavy metal soil pollution using different indices. Pollution indices are widely considered a useful tool for the comprehensive evaluation of the degree of contamination. Moreover, they can have a great importance in the assessment of soil quality and the prediction of future ecosystem sustainability, especially in the case of farmlands.

Heat stress in the heart and muscle of the Antarctic fishes Notothenia rossii and Notothenia coriiceps: Carbohydrate metabolism and antioxidant defence.

Carbohydrate metabolism and the antioxidant defence system of heart and muscle of the Antarctic notothenioids Notothenia rossii and Notothenia coriiceps were evaluated in response to heat stress (8 °C) over 144 h. N. rossii heart exhibited decreased glycolysis and aerobic metabolism after up to 12 h of exposure to 8 °C, and anaerobiosis was inhibited within 24 h.

Effects of heat stress on the renal and branchial carbohydrate metabolism and antioxidant system of Antarctic fish.

The objective of the present study was to assess the effect of short-term (2-144 h) heat stress (8 °C) on energy production processes and antioxidant defense systems in the kidneys and gills of Notothenia rossii and Notothenia coriiceps. Heat stress affected energy metabolism and oxidative stress parameters in a time-, tissue-, and species-dependent manner, and gills were more sensitive than kidneys to heat stress. N.

Assessment of heavy metals contamination in surface layers of Roztocze National Park forest soils (SE Poland) by indices of pollution.

In most cases, in soils exposed to heavy metals accumulation, the highest content of heavy metals was noted in the surface layers of the soil profile. Accumulation of heavy metals may occur both as a result of natural processes as well as anthropogenic activities. The quality of the soil exposed to heavy metal contamination can be evaluated by indices of pollution.

Soil pollution indices conditioned by medieval metallurgical activity - A case study from Krakow (Poland).

The studied soil profile under the Main Market Square (MMS) in Krakow was characterised by the influence of medieval metallurgical activity. In the presented soil section lithological discontinuity (LD) was found, which manifests itself in the form of cultural layers (CLs). Moreover, in this paper LD detection methods based on soil texture are presented.

Tenosynovial Giant Cell Tumor in the Dermis of the External Auditory Meatus.

A 26-year-old African American woman with a history of a recurring "oozing papule" in the right ear presented to the emergency department in July 2010 with a 2-month history of an enlarging, painful growth in the right ear canal. Physical examination revealed a 1-cm round cystic lesion along the right, anterior external auditory canal wall, just medial to the tragus. Initial diagnosis was an infected cyst of the external ear canal.

Effect of temperature acclimation on the liver antioxidant defence system of the Antarctic nototheniids Notothenia coriiceps and Notothenia rossii.

The aim of this study was to determine whether endemic Antarctic nototheniid fish are able to adjust their liver antioxidant defence system in response to the temperature increase. The activity of the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) enzymes as well as the content of non-enzymatic oxidative stress markers such as reduced glutathione (GSH), lipid peroxidation (LPO) and protein carbonyl (PC) were measured in the liver of two Antarctic fish species, Notothenia rossii and Notothenia coriiceps after 1, 3 and 6days of exposure to temperatures of 0°C and 8°C. The GST activity showed a downregulation in N.

Morphological and morphometric variability of the squid Lolliguncula brevis (Mollusca: Cephalopoda) in Brazilian waters: evidence for two species in the Western Atlantic?

Morphological and morphometric variability of the small-sized coastal squid Lolliguncula brevis was assessed along the largest part of its latitudinal range in the southern hemisphere, off the Brazilian coast (8º S - 27º S). A general homogeneity in form was found throughout the entire latitudinal range. In terms of body proportions, no latitudinal gradients were evident, but a few local "morphotypes" could be distinguished.

Heavy metal sensitivity and bioconcentration in oribatid mites (Acari, Oribatida) Gradient study in meadow ecosystems.

In this study we aimed to identify different reactions of oribatid species to heavy metal pollution and to measure concentrations of cadmium, zinc and copper in oribatid species sampled along a gradient. Oribatid mites were sampled seasonally during two years in five meadows located at different distances from the zinc smelter in the Olkusz District, southern Poland. Oribatids were shown to withstand critical metal concentration and established comparatively abundant and diverse communities.

Demonstration of ignition radiation temperatures in indirect-drive inertial confinement fusion hohlraums.

We demonstrate the hohlraum radiation temperature and symmetry required for ignition-scale inertial confinement fusion capsule implosions. Cryogenic gas-filled hohlraums with 2.2 mm-diameter capsules are heated with unprecedented laser energies of 1.

Effect of Polonite used for phosphorus removal from wastewater on soil properties and fertility of a mountain meadow.

Reactive filter materials used for phosphorus (P) removal from wastewater can be disposed of as soil amendments after treatment, thus recycling P and other macro- and micro-nutrients to plants. In addition, materials with a high pH and Ca content, such as Polonite, are potential soil conditioners, which can be particularly beneficial for acid soils. Polonite previously used for on-site wastewater treatment was applied as a soil amendment to a mountain meadow.

Effect of reactive substrates used for the removal of phosphorus from wastewater on the fertility of acid soils.

Reactive substrates used in filter systems can reduce phosphorus (P) pollution and, once saturated with P, may be recycled in agriculture. These substrates are usually calcium carbonate derivates with high pH values, which may be particularly beneficial for acid soils. Three reactive substrates (Filtra P, Polonite and wollastonite) saturated with P were used as amendments to an acid soil in a pot experiment.

Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase.

Picromycin/methymycin synthase (PICS) is a modular polyketide synthase (PKS) that is responsible for the biosynthesis of both 10-deoxymethynolide (1) and narbonolide (2), the parent 12- and 14-membered aglycone precursors of the macrolide antibiotics methymycin and picromycin, respectively. PICS module 2 is a dehydratase (DH)-containing module that catalyzes the formation of the unsaturated triketide intermediate using malonyl-CoA as the chain extension substrate. Recombinant PICS module 2+TE, with the PICS thioesterase domain appended to the C-terminus to allow release of polyketide products, was expressed in Escherichia coli.

Scaling near the quantum-critical point in the SO(5) theory of the high-T(c) superconductivity.

We study the quantum-critical point scenario within the unified theory of superconductivity and antiferromagnetism based on the SO(5) symmetry. Closed-form expression for the quantum-critical scaling function for the dynamic spin susceptibility is obtained from the lattice SO(5) quantum nonlinear sigma-model in three dimensions, revealing that in the quantum-critical region the frequency scale for spin excitations is simply set by the absolute temperature. Implications for the non-Fermi liquid behavior of the normal-state resistivity due to spin fluctuations in the quantum-critical region are also presented.

[Factors deciding on attending hard-of-hearing or deaf children schools].

The aim of this work was to elucidate the deciding factors of selection of pupils to hard-of-hearing and deaf children schools. The material consisted of 138 hard-of-hearing and 170 deaf school children, aged from 6 to 16 years. The hard-of-hearing children revealed severe and profound hearing impairments, passed through on the average two and half years of hearing and speech rehabilitation before entering to the school and used continually all day their hearing aids.