Development of Simvastatin Loaded Electrospun Zein Nanofiber Membranes for Bone Repair.

The present study aims to prepare and And Characterization of zein nanofibers with simvastatin-loaded in it by electrospinning method using a polymeric matrix prepared from zein solution containing simvastatin antibiotics. The physical, cellular properties and drug release kinetics of the fibers were studied. Fiber formation was investigated by implementing a scanning electron microscope (SEM).

Modeling Physico-Chemical Properties of Quinolone Derivatives Using GA-MLR as a Computational Study.

Background: In this study, we used a hierarchical approach to develop quantitative structure-activity relationship (QSAR) models for modeling physico-chemical properties of quinolone derivatives.

Objective: The relationship between some of the molecular descriptors with physic-chemical properties such as refractive index (n), polarizability (α) and HOMO-LUMO energy gap (ΔEH-L) was represented.

Materials And Methods: Quantum mechanical calculations using abinitio method at the #HF/6- 31++G** level were carried out to obtain the optimized geometry and then, the comprehensive set of molecular descriptors was computed by using the Dragon software.

Prediction of Lipophilicity of some Quinolone Derivatives by using Quantitative Structure-Activity Relationship.

Objectives: Quantitative structure activity relationship (QSAR) was used to study the partition coefficient of some quinolones and their derivatives.

Methods: These molecules are broad-spectrum antibiotic pharmaceutics. First, data were divided into two categories of train and test (validation) sets using a random selection method.