Publications by authors named "Zakiye Mokhames"
Article Synopsis
- Global real-time monitoring of SARS-CoV-2 variants is essential for controlling COVID-19, leading to the development of a Sanger-based platform for variant tracking in low-resource labs.
- The study utilized nested RT-PCR and Sanger sequencing on 1,028 samples, achieving high concordance with whole genome sequencing for mutation detection and lineage assignment.
- The new method is effective for tracking variants of concern like Delta and Alpha, making it a viable option for countries with limited resources to monitor SARS-CoV-2 variants efficiently.
Article Synopsis
- The study analyzed the genetic diversity of SARS-CoV-2 in Iran over one year, following two independent viral introductions during the early outbreak phase.
- Researchers sequenced 319 whole genomes between March 2020 and May 2021 to monitor the circulating viral lineages.
- Results showed that different SARS-CoV-2 clades dominated various waves of infection, with the Delta variant emerging as a crucial factor in the fifth wave, highlighting significant mutations in key lineages.
Article Synopsis
- The study investigates the expression of CNR1 and CNR2 genes, which are part of the endocannabinoid system, in COVID-19 patients with and without diabetes to understand their potential role in the disease.* -
- Researchers isolated peripheral blood monocytes from eight groups (including COVID-19 patients, diabetics, and healthy individuals) and used real-time PCR to analyze gene expression levels.* -
- Findings showed that CNR1 and CNR2 gene expression was significantly higher in severe and moderate COVID-19 patients compared to healthy controls, suggesting a potential link between the endocannabinoid system and COVID-19 severity.*
Article Synopsis
- - The study aimed to explore the use of quaternary ammonium compounds, specifically a combination of Diphenhydramine and Ammonium Chloride, to improve outcomes for COVID-19 patients.
- - In a trial with 120 participants, those receiving the Ammonium Chloride had lower recovery times and reduced viral burden compared to those receiving only Diphenhydramine, although overall mortality rates did not significantly differ.
- - The researchers conclude that adding Ammonium Chloride to standard care may benefit COVID-19 patients, particularly in terms of recovery and viral load.
The SARS-CoV-2 virus has been rapidly spreading globally since December 2019, triggering a pandemic, soon after its emergence. While Iran was among the first countries confronted with rapid spread of virus in February 2020, no real-time SARS-CoV-2 whole-genome tracking in early phase of outbreak was performed in the country. To address this issue, we provided 50 whole-genome sequences of viral isolates ascertained from different geographical locations in Iran during March-July 2020.
View Article and Find Full Text PDFBackground: The novel coronavirus disease 2019 (COVID-19) was emergency turned into global public health after the first patients were detected in Wuhan, China, in December 2019. The disease rapidly expanded and led to an epidemic throughout China, followed by the rising number of cases worldwide. Given the high prevalence of COVID-19, rapid and accurate diagnostic methods are immediately needed to identify, isolate and treat the patients as soon as possible, decreasing mortality rates and the risk of public contamination by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).
View Article and Find Full Text PDFBladder dysfunction is one of the most common diseases that occur for a number of reasons and the current treatment modalities do not improve much in its recovery process. Tissue engineering in the last two decades has given great hope for the treatment of these disorders. In this study, a composite nanofibrous scaffold was fabricated from chitosan, collagen, and polyvinyl-alcohol polymer blend while curcumin incorporated in scaffold fibers.
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