Evaluation the -174G>C Genetic Polymorphism of Interleukin-6 in Iranian Patients with Chronic Lymphocytic Leukemia.

Background & Objective: Interleukin-6 (IL-6) is involved in inflammation and has a significant role in chronic lymphocytic leukemia (CLL) progression. Accordingly, IL-6 level may increase in CLL-affected patients compared to healthy individuals. The -174G>C single nucleotide polymorphism (SNP) in IL-6 promoter region has been related to differences in IL-6 transcription.

Regulatory Effects of Apatinib in Combination with Piperine on MDM-2 Gene Expression, Glutathione Peroxidase Activity and Nitric Oxide level as Mechanisms of Cytotoxicity in Colorectal Cancer Cells.

Apatinib has been utilized in colon cancer therapies but its efficiency and molecularmechanism are not fully understood. Chemotherapy in combination with non-toxic compoundscan be an effective treatment strategy for cancer. Consequently, this study was carried out toevaluate the effects of apatinib and piperine on colorectal cancer (CRC) cell line and theirpotential anti-cancerous mechanisms in vitro.

Carboplatin and epigallocatechin-3-gallate synergistically induce cytotoxic effects in esophageal cancer cells.

Background And Purpose: We aimed at evaluating the effects of combinatorial treatments with carboplatin and epigallocatechin-3-gallate (EGCG) on the KYSE-30 esophageal cancer (EC) cell line and elucidate the underlying mechanisms.

Experimental Approach: EC cells were harvested and exposed to increasing concentrations of carboplatin and EGCG to construct a dose-response plot. Cell inhibitory effects were assessed by the MTT method and apoptosis-related gene expression levels (caspases 8 and 9) and Bcl-2 mRNA were detected using real-time polymerase chain reaction.

Herpes Simplex Virus Type 2 Seroprevalence in Pregnant Women in Urmia, Northwest of Iran, during 2014-2015.

Background: Herpes simplex virus type 2 (HSV-2) seroprevalence has been shown to be a potential sign of infection in pregnant women, and it could be applied to check HSV-2 transmission. This study evaluated the anti-HSV-2 IgG prevalence in pregnant women who were referred to health centers in Urmia, Northwest of Iran, during 2014-2015.

Methods: Serum samples were collected from 86 pregnant women and tested for Anti-HSV-2-specific IgG using a commercial enzyme-linked immunosorbent assays kit.

Human parvovirus B19 in Iranian pregnant women: a serologic survey.

Background: Parvovirus B19 infection is associated with clinical symptoms that vary in the spectrum from trivial to severe. The important clinical manifestations are erythema infectiosum or the fifth disease, transient aplastic anemia in patients with hemoglobinopathies, acute polyarthralgia syndrome in adults, hydrops fetalis, spontaneous abortion and stillbirth. Acute infection in nonimmune pregnant women can lead to fetal hydrops.

The seroprevalence of Parvovirus B19 among kidney transplant recipients: a single-center study.

Parvovirus B19 is a DNA virus that is responsible for causing several diseases in humans. Parvovirus B19-induced persistent anemia is one of its manifestations that is relatively common in transplant recipients. This study was aimed to investigate the seroprevalence of parvovirus B19 among kidney transplant recipients.

Seroprevalence of hepatitis e among pregnant women in urmia, iran.

Background: While hepatitis E virus (HEV) mostly causes self-limited disease in general population, it is more severe in pregnant women.

Objectives: This study aimed to investigate the seroprevalence of anti-HEV IgG among a population of pregnant women in West Azerbaijan of Iran .

Patients And Methods: One hundred thirty six pregnant women referred to urban health centers of Urmia for pursuing pregnancy-related health services were enrolled in a descriptive, cross-sectional study.

Seroprevalence of hepatitis E among Iranian renal transplant recipients.

Background: Renal transplant recipients are known to be susceptible to viral infections, with more severe clinical presentations compared to healthy persons. Hepatitis E is generally a self-limited disease, which is caused by hepatitis E virus. Recently, hepatitis E has become more important in organ transplant recipients, because of new findings regarding the potential for chronic infections in this patient group.

Seroprevalence of HTLV-1 among kidney graft recipients: a single-center study.

Background: Renal transplant recipients are susceptible to viral infections because of their immunocompromised background. HTLV-1 is a retrovirus that leads to adult T-cell leukemia/lymphoma or myelopathies. This study aimed to evaluate HTLV-1 antibodies among renal transplant recipients in Urmia, Iran.

Seroprevalence of herpes simplex virus-2 in kidney transplant recipients: a single-center experience.

Introduction: Viral infections are a real threat in kidney transplant recipients because of their immunocompromised condition. This study aimed to evaluate herpes simplex virus-2 (HSV-2) seropositivity among kidney transplant recipients.

Materials And Methods: Serum samples of 91 kidney transplant recipients from Urmia, Iran, were examined serologically for antibodies against HSV-2 using an enzyme-linked immunosorbent assay.

Survey the seroprevalence of CMV among hemodialysis patients in Urmia, Iran.

Cytomegalovirus (CMV) causes infection in immunocompromised, transplant recipients and those who received blood transfusion frequently. Risk factors for primary CMV infection are blood transfusion (including clotting factors, etc), recipients of infected transplants, hemo-dialysis and the frequency of dialysis in a week. This study aimed at determining the prevalence of cytomegalovirus (CMV) antibodies in end-stage renal disease (ESRD) patients who undergo hemodialysis.

Antimicrobial susceptibility pattern of urinary tract pathogens.

Microbial drug resistance is a major problem in the treatment of infectious diseases worldwide. The purpose of this survey is to determine the prevalence of the type of bacterial agents that cause urinary infection and to assess the antimicrobial sensitivity pattern in the Urmia Medical University, Iran. In the period between 2005 and 2006, urine cultures collected were analyzed.

Survey of the seroprovalence of HTLV I/II in hemodialysis patients and blood donors in Urmia.

Human T lymphocytotropic virus HTLV is a virus from retroviridae family, and more than 20 million people are infected with this virus worldwide. It can cause leukemia/lymphoma in adults, tropical spastic paralysis, HTLV associated myelopathy, spastic paraparesis, tropical myelopathy (HAM/TSP), and some other nervous system diseases. It is transmitted by means of blood products via blood transfusion.

Survey of hepatitis B status in hemodialysis patients in a training hospital in Urmia, Iran.

To evaluate the prevalence of HBV infection in chronic hemodialysis patients at our dialysis center of Urmia's Taleqni Hospital, Urmia, Iran, we studied cross-sectionally the hepatitis surface antigen (HbsAg) status in blood samples of 167 active chronic hemodialysis patients at our center with enzyme linked immunosorbant assay (ELISA). The mean frequency of HbsAg+ was 6.58%, which was higher in patients less than 50 years old than in those above 50 years (9.

Occurrence of cytomegalovirus infection and factors causing reactivation of the infection among renal transplant recipients: a single center study.

Reactivation of infection with the cytomegalovirus (CMV) in renal transplant recipients may cause significant morbidity and mortality. To evaluate factors associated with activation of CMV replication, we followed prospectively a group of 68 renal transplant recipients for 12 months. The control group consisted of healthy blood donors (n = 37).