Publications by authors named "Zakieh Golshadi"
Article Synopsis
- This study examined the impact of the rs1801276 polymorphism in the insulin receptor substrate 1 gene on the risk of developing nonalcoholic fatty liver disease (NAFLD).
- Researchers compared 127 healthy controls and 123 patients with biopsy-confirmed NAFLD, finding significant differences in the distribution of rs1801276 genotypes and alleles between the two groups.
- The findings suggest that the "GG+GC" genotypes and "G" alleles are less common in NAFLD patients, indicating a potential protective effect, but further research is needed to clarify this gene's role in NAFLD risk.
Clearance of accumulated protein aggregates is one of the functions of autophagy. Recently, a clearer understanding of non-coding RNAs (ncRNAs) functions documented that ncRNAs have important roles in several biological processes associated with the development and progression of neurodegenerative disorders. Subtypes of ncRNA, including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), are commonly dysregulated in neurodegenerative disorders such as Alzheimer and Parkinson diseases.
View Article and Find Full Text PDFTGF-β1 receptor blockade attenuates unilateral ureteral obstruction-induced renal fibrosis in C57BL/6 mice through attenuating Smad and MAPK pathways.
J Mol Histol
August 2022
Renal fibrosis is characterized by accumulation of extracellular matrix components and collagen deposition. TGF-β1 acts as a master switch promoting renal fibrosis through Smad dependent and/or Smad independent pathways. Thirty-five male C57BL/6 mice were divided into five groups of seven each; sham, unilateral ureteral obstruction (UUO), UUO+galunisertib (150 and 300 mg/kg/day), galunisertib (300 mg/kg/day).
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