Fotemustine is a cytotoxic drug belonging to the group of nitrosourea derivatives, and is used in the treatment of metastatic melanoma, particularly when secondary brain lesions are present. We report the case of a female patient in partial response following 10 courses of fotemustine and featuring a rapidly progressing mental impairment. The clinical and radiological patterns were consistent with a fotemustine-related toxic encephalopathy, as described previously in a recent report.
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