Cellular and Non-cellular Antioxidant Properties of Vitamin E-Loaded Metallic-Quercetin/Polycaprolactone Nanoparticles for the Treatment of Melanogenesis.

Inhibition of melanogenesis by quercetin and vitamin E is extensively reported in the literature, independently, with limitations in antioxidant potential owing to less permeation, solubility, decreased bioavailability, and reduced stability. Thus, the aim of the present study was to synthesize a novel complex of metal ions (copper and zinc) with quercetin to enhance antioxidant properties which were confirmed by docking studies. Polycaprolactone-based nanoparticles of the synthesized complex (PCL-NPs, Q-PCL-NPs, Zn-Q-PCL-NPs, Cu-Q-PCL-NPs) were made later loaded with vitamin E which made the study more interesting in enhancing antioxidant profile.

Effects of diet on body weight, haemoglobin, serum proteins and trace elements in burned children.

Objective: To compare the effect of two diets on serum proteins, trace elements, haemoglobin and body weight in burned children.

Design: Comparative analytical study.

Place And Duration Of Study: The study was conducted on burned children admitted in Nishtar Ward, Allied Hospital, Faisalabad for seven months, from February to August 2002.