Cannabinoids inhibit the respiration of human sperm.

Objective: To investigate the effects of the psychotropic compounds Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and Delta(8)-tetrahydrocannabinol (Delta(8)-THC) on sperm mitochondrial O(2) consumption (respiration).

Setting: State University of New York Upstate Medical University, Syracuse, New York.

Patient(s): Forty-one men who visited the andrology laboratory for fertility evaluation.

Inhibition of human sperm respiration by 4-hydroperoxycyclophosphamide and protection by mesna and WR-1065.

Objective: To determine the effect of 4-hydroperoxycyclophosphamide (4OOH-CP) on the respiration of human sperm, and investigate the protective properties of mesna and WR-1065.

Setting: SUNY Upstate Medical University, Syracuse, NY.

Patient(s): Men (n = 12) visited the Andrology Department for fertility evaluation.