[The anti-allergic activity and mechanism of action of gamma-carboline derivatives].

The antianaphylactic effect of new antihistaminic agents by derivatives of gamma-carboline dimebon and meraboin was studied by the method of passive cutaneous anaphylaxis. It was found that the agents in a dose amounting to 10% of LD50 possessed a high anaphylactic activity which did not correlate with the degree of their antihistaminic effect. During in vitro experiments the mechanism of action of dimebon and meraboin can be conditioned also by their ability to decrease histamine release from mast cells and to reduce the activity of cAMP-dependent phosphodiesterase.

[Electronic device for determining motor activity].

The authors present a short description and the principal scheme of an electron apparatus for the determination of the motor activity of laboratory animals. This apparatus is based on the principle of recording the changes in volume occurring during the movement of animals.

[Effect of hypoxia on mitochondrial stability].

The mitochondria isolated from the liver of rats subjected to acute hypoxia (10 km, 2h) are established to 0e less stable to the damage effect of incubation in the substratefree medium than the mitochondria of the control animals. A long interrupted adaptation to hypoxia as well as a single introduciton of p-chlorophenoxyacetic acid diethylaminoethylamide prevents a decrease in stability of the mitochondrial structures which is observed in rats during hypoxia. Addition of p-chlorophenoxyacetic acid diethylaminoethylamide into the incubation medium also inhibits the damage of the liver mitochondria.

[Biochemical mechanisms of the antihypoxic effect of amichlorphen (diethylaminoethylamide parachlorphenoxyacetic acid)].

Test set up on albino rats demonstrated a preliminary introduction of amichlophene to prevent a hypoxic fall in the level of highly ergastic compounds in the tissues owing to stimulation of the mitochondrial respiration processes and increased energy-producting effectiveness of the latter. The beneficial effect of amichlophen on the bioenergetics of the tissues in acute hypoxia is largely caused by the continued structural and functional integrity of the mitochondria, lysosomes and other cellular organellae which is due to the inhibitory action of the compound on the prosses of lipids reoxidation and to the activity of phospholipase A.

[Pharmacological properties of some p-chlorophenoxyacetic acid derivatives].

Among some derivatives of p-chlorophenoxyacetic acid (dialkylaminoethyl, diethylaminoethylmercaptomercaptan and tropine ethers, dialkylaminoethylene amides) there have been discovered compounds with marked neurotropic, locally anesthetic, antiarrhythmic and antihypoxic properties.