Publications by authors named "Zakaria Dzulkarnaen Andee"
The functional -94 insertion/deletion ATTG polymorphism in the promoter region of NFKB1 gene increases the risk of sporadic colorectal cancer.
Mohd Shafi'i Mohd Suzairi Shing Cheng Tan Abdul Aziz Ahmad Aizat Mustapha Mohd Aminudin Mohd Shahpudin Siti Nurfatimah Zakaria Dzulkarnaen Andee
Cancer Epidemiol
October 2013
Article Synopsis
- The study aimed to explore the relationship between the NFKB1 -94 ins/del ATTG (rs28720239) polymorphism and colorectal cancer (CRC) risk among Malaysians by analyzing allele and genotype frequencies.
- Researchers analyzed DNA from 474 individuals, including 237 CRC patients and 237 cancer-free controls, using PCR-RFLP and confirmed results with DNA sequencing.
- Findings indicated that the variant genotype was more common in CRC patients (14.8%) compared to controls (6.8%) and was associated with a significantly higher risk of CRC (OR=2.42).