Publications by Zaixing Du

Publications by authors named "Zaixing Du"

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Ubiquitination of ATAD3A by TRIM25 exacerbates cerebral ischemia-reperfusion injury via regulating PINK1/Parkin signaling pathway-mediated mitophagy.

Xin Li Liyang Guan Zhi'en Liu Zaixing Du Qianhui Yuan

Free Radic Biol Med

November 2024

Article Synopsis

Cerebral ischemia-reperfusion injury (CI/RI) leads to neuronal damage, with mitophagy's role in this process still debated.
The study hypothesized that TRIM25 enhances mitophagy through the ubiquitination of ATAD3A, aggravating CI/RI.
Experiments demonstrated that TRIM25 reduces ATAD3A, promoting mitophagy via the PINK1/Parkin pathway, and highlighting a complex interaction between these proteins during ischemic injury.

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Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?

Ying Che Xiaolong Lu Xueting Wang Zhien Liu Liyang Guan Zaixing Du

Cancer Cell Int

August 2024

rAj-Tspin, a soluble recombinant peptide from Apostichopus japonicus, can inhibit the integrin β1 (ITGB1)/FAK/AKT signaling pathway in hepatocellular carcinoma (HCC) via cell epithelial-mesenchymal transition (EMT) and apoptosis. Zyxin (ZYX) is a focal adhesion protein that is considered a novel mediator of EMT and apoptosis. However, the inhibitory mechanisms of rAj-Tspin in HCC and whether it is related to ZYX are unclear.

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