Sub-acute Inhalation Exposure to Aluminum Oxide Nanoparticles and its Effects on Wistar Rats as Opposed to the Micro-sized Chemical Analog.

Introduction: Aluminum oxide nanoparticles (AlO NPs) are widely used in various productions. Simultaneously, many research works report the toxic effects of this nanomaterial. Given that, there is a growing risk of negative effects produced by AlO NPs on public health.

[Identification of potential hazards and analysis of critical control points in cultured meat production].

The development of food technologies at the present stage is aimed at expanding the range of food raw materials, including alternative food sources. One of such sources is meat derived from in vitro stem cells or cultured meat. The stages of in vitro meat production could be divided into four blocks: preparation of raw materials, cultivation of cells in a nutrient medium, forming the final product and preparing meat for sale to the consumer.

[Comparative characteristics of the amino acid composition of protein from traditional sources and entomoprotein: calculated data].

The growth of the world population leads to an increase in demand for food consumption. Along with the projected reduction in demand for meat products, a search is underway for a new type of food ("novel food"), one of the promising options for which are insects. In 2023 the European Commission has registered flour made from house cricket (Acheta domesticus) as a "novel food" for human consumption.

[Health risk assessment associated with priority potentially hazardous chemical compounds detected in canned meat and meat-and-vegetable food for infants].

Assessment of public health safety associated with chemical contaminants consumed with food is an important component for solving the tasks of ensuring the sanitary and epidemiological well-being of the population. For these purposes, it is necessary to establish priority potentially dangerous compounds among the identified undeclared and unintended chemical contaminants for further consumers risk assessment. In conditions of unacceptable levels of health risk, it is necessary to decide whether it is advisable to develop new or change existing hygiene standards for these substances.

Novel B-Cell Epitopes of Non-Neutralizing Antibodies in the Receptor-Binding Domain of the SARS-CoV-2 S-Protein with Different Effects on the Severity of COVID-19.

Antibodies against the receptor-binding domain of the SARS-CoV-2 spike protein (RBD S-protein) contribute significantly to the humoral immune response during coronavirus infection (COVID-19) and after vaccination. The main focus of the studies of the RBD epitope composition is usually concentrated on the epitopes recognized by the virus-neutralizing antibodies. The role of antibodies that bind to RBD but do not neutralize SARS-CoV-2 remains unclear.

Porous PZT Films: How Can We Tune Electrical Properties?

Porous ferroelectric lead zirconate titanate (PZT) films are a promising material for various electronic applications. This study focuses on understanding how the structure-directing agent, polyvinylpyrrolidone, can alter the structure and electrical properties of porous PZT films prepared through chemical solution deposition. Films with various porosities of up to ~40 vol.

Antibodies Capable of Enhancing SARS-CoV-2 Infection Can Circulate in Patients with Severe COVID-19.

Antibody-dependent enhancement (ADE) has been shown previously for SARS-CoV-1, MERS-CoV, and SARS-CoV-2 infection in vitro. In this study, the first monoclonal antibody (mAb) that causes ADE in a SARS-CoV-2 in vivo model was identified. mAb RS2 against the SARS-CoV-2 S-protein was developed using hybridoma technology.

[Determination of toxic element concentrations in flour and cereal products by mass spectrometry with inductively coupled plasma].

Systemic control and monitoring in the sphere of providing sanitary epidemiological welfare of population require routine procedures for determining toxic elements in variable foodstuffs. Their development is a pressing issue. Our research was to develop a procedure for determining concentrations of arsenic, cadmium, lead, mercury, aluminum and strontium in flour and cereal products by mass spectrometry with inductively coupled plasma.

[The modification of methodological approaches for potential hazard identification of inadvertent chemicals in food].

The existing methodological approaches for hazard identification and selection of priority hazard contaminants in foodstuff for further health risk assessment and legislation (in case of need) do not represent the reasons of inclusion inadvertent chemical substances in a number of priority for health risk assessment. The absence both of complex assessment and potential hazard categories of contaminants do not allow to assess the urgency of health risk assessment. Thus, it's advisable to expand the existing methodological approaches with the criteria of selection of hazard inadvertent chemical substances in food.

Practical Aspects of Using Multifractal Formalism to Assess the Morphology of Biological Tissues.

Unlabelled: is to identify practical aspects of using multifractal formalism to assess the morphology of biological tissues.

Materials And Methods: The objects of the study were histological images of lung tissues of Wistar rats without pathology and with detected pathological changes, obtained at 50×, 100×, 200× magnifications. Image processing was carried out using the ImageJ/Fiji universal software.

[Nutrition monitoring in secondary education institutions].

Nutrition provided to children at school is a factor that exerts most significant influence on their health. However, certain issues remain unresolved in the sphere and this initiated nutrition monitoring within the "Demography" Russian National Project. of this study was to analyze the results of nutrition monitoring in secondary education institutions located in Perm region in order to determine priority indicators for its further estimation.

Peculiarities of bioaccumulation and toxic effects produced by nanoparticles of molybdenum (VI) oxide under multiple oral exposure of rats: examination and comparative assessment.

Introduction: Molybdenum (VI) oxide nanoparticles (MoO3 NPs) are widely used in various economic activities. This creates elevated risks of exposure to this nanomaterial for workers and population in general and, consequently, there can be an increased number of developing pathological changes caused by exposure to MoO3 NPs.

Objective: To examine and comparatively assess peculiarities of bioaccumulation and toxic effects produced by MoO NPs under multiple oral introductions.

[Identification and chromatemass- spectrometry quantification of toxic chemicals (N-nitrosamines, phthalates) in baby foods].

Currently, assessing exposure to toxic chemicals detected in foodstuffs is a vital issue, especially regarding foods for babies and toddlers. The research was to identify and quantify toxic chemicals (N-nitrosamines, phthalates) in baby foods. .

Indicators of Immune and Neurohumoral Profile in Women of Fertile Age with Functional Disorders of the Autonomic Nervous System Associated with Polymorphic Variants of the HTR2A (rs7997012) and TP53 (rs1042522) Genes.

In women of fertile age with functional disorders of the autonomic nervous system (ANS), a complex of indicators of the immune and neurohumoral profile associated with polymorphic variants of the HTR2A (rs7997012) and TP53 (rs1042522) genes was revealed. In patients with the diagnosis "G90.8.

Features Neurohumoral and Immune Profile in Children with Functional Disorders of the Autonomic Nervous System Associated with Sirtuin Gene SIRT1 (rs7069102) Polymorphism.

We revealed some features of the neurohumoral and immune profile in preschool children with functional disorders of the autonomic nervous system (ANS) associated with the polymorphism of the SIRT1 gene (rs7069102) responsible for stability of the cell cycle, energy and plastic metabolism of organic substances, and Ca exchange. The neurohumoral profile of the surveyed children is characterized by excessive content of glutamic acid and serotonin, which leads to excessive synaptic activation and disorders of ANS inhibition (p<0.05).

[The methodological approaches to classification of diseases of blood circulation system according to severity degree based on statistic data of population appealing for medical care].

In The Russian Federation, increasing of life expectancy and decreasing of mortality related to diseases of circulatory system are the priorities of state policy. The purpose of study was to develop approaches to the classification of cardiovascular diseases by severity degree within the framework of development of general health management model based on health care activities at the regional level. The article describes methodology of calculating indices of cardiovascular diseases severity based on statistical data of appealability for out-patient, in-patient and emergency medical care.

SARS-CoV-2 Seroprevalence Structure of the Russian Population during the COVID-19 Pandemic.

The SARS-CoV-2 pandemic, which came to Russia in March 2020, is accompanied by morbidity level changes and can be tracked using serological monitoring of a representative population sample from Federal Districts (FDs) and individual regions. In a longitudinal cohort study conducted in 26 model regions of Russia, distributed across all FDs, we investigated the distribution and cumulative proportions of individuals with antibodies (Abs) to the SARS-CoV-2 nucleocapsid antigen (Ag), in the period from June to December 2020, using a three-phase monitoring process. In addition, during the formation of the cohort of volunteers, the number of seropositive convalescents, persons who had contact with patients or COVID-19 convalescents, and the prevalence of asymptomatic forms of infection among seropositive volunteers were determined.

Features of Bioaccumulation and Toxic Effects of Copper (II) Oxide Nanoparticles Under Repeated Oral Exposure in Rats.

Background: Currently, the range of copper (II) oxide nanoparticles' (CuO NPs) applications is expanding and the global production of CuO NPs is increasing. In this regard, the risk of exposure of the population to this nanomaterial is increasing.

Objective: The aim of the study is to investigate the patterns of bioaccumulation and toxic effects of CuO NPs after multiple oral exposures.

Conditions of Aerogenic Exposure to Benzene and Genetic Status as Factors of Formation of Immune Profile Features in Men with Autonomic Regulation Disturbances.

We studied the immunological status and polymorphic variants of candidate genes in men with disturbances of autonomic nervous regulation under conditions of aerogenic exposure to benzene. The group of men with pathology of the autonomic nervous system (autonomic dysfunction syndrome) living under conditions of aerogenic exposure to benzene is characterized by increased blood contamination with benzene, which 1.5-fold surpassed this parameter in the group of conventionally healthy men (p<0.

Study of Hematological Parameters and Morphometric Indices of Erythrocytes in Rats Exposed to Calcium Oxide Nanoparticles.

In female Wistar rats, we studied the effects of daily 20-day administration of intragastric suspension of nanosized calcium oxide on hematological indices (the counts of erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, basophils, lymphocytes, monocytes, stab/segmented neutrophils, and the eosinophil-to-lymphocyte ratio) and morphometric parameters of erythrocytes (equivalent Feret's diameter, sphericity, aspect ratio, and convexity). The study revealed significantly (up to 3.1 times) decreased levels of hemoglobin, platelets, hematocrit, averaged content of hemoglobin in erythrocyte, and platelet volume relatively to the control values.

Peculiarities of Immune Regulation in Men of Perm Region with Atherosclerosis Related to Polymorphism of Candidate Genes.

The study examined peculiarities of immune regulation and associated polymorphic variants of candidate genes in men with atherosclerosis in Perm region. The revealed deficiency of CD127 lymphocytes and Annexin V-FITC7AAD cells, as well as enhanced level of CD3CD4 lymphocytes against the background of variant alleles of candidate genes FAS (rs1159120), CPOX (rs1131857) and wild-type alleles SULT1A1 (rs9282861), MMP9 (rs17576) are responsible for peculiar features of hereditary determination and pathogenesis of atherosclerosis in examined sample (p<0.05).

[Comparative assessment of N-nitrosamines' contamination of baby's canned meat with vegetables and cereals by various methods in Russia and Vietnam].

The quality and safety of food, intended for baby in particular, is one of the global issues of our time. The group of carcinogenic N-nitrosamines is of especially dangerous. It is worth mentioning that currently there are no standards for their content in Vietnam.

Morphometry of Sperm Head in Rats Treated with an Antifungal Medication.

The parameters of sperm head in Wistar male rats orally treated with antifungal agent for 48 days during spermatogenesis were studied by the method of image analysis. The degree of roundness (roughness) of sperm head was calculated. Significant differences in morphometric parameters of sperm head, such as length, width, head angle, and roundness were revealed between the treatment and control group.