Increased Expression of Plasma-Induced ABCC1 mRNA in Cystic Fibrosis.

The gene is structurally and functionally related to the cystic fibrosis transmembrane conductance regulator gene (). Upregulation of is thought to improve lung function in patients with cystic fibrosis (CF); the mechanism underlying this effect is unknown. We analyzed the promoter single nucleotide polymorphism (SNP rs504348), plasma-induced mRNA expression levels, and methylation status and their correlation with clinical variables among CF subjects with differing mutations.