Assessment of salivary and gingival crevicular fluids IL6, IL-8, IL-12, and IL-17 levels in healthy subjects and patients with periodontal disease.

Background: Biomarkers present in the oral fluid (saliva and GCF) have been studied thoroughly in order to be used as adjuncts to the diagnosis of periodontal disease. In periodontal diseases, inflammatory mediators, including IL6, IL-8, IL-12, and IL-17, may promote the degeneration of periodontal tissues.

Aim: The aim of the present study was to quantify IL6, IL-8, IL-12, and IL-17 levels in the saliva and GCF for patients with generalized periodontitis and compare it with healthy subjects.