Effectiveness of Implantable Doppler Probe Versus Standard Clinical Care in Preventing Thrombosis-Related Graft Loss in Kidney Transplantation: A Systematic Review and Meta-Analysis.

Objectives: The implantable Doppler probe can monitor the patency of vascular anastomosis, thereby facilitating early detection of vascular thrombosis critical to reducing graft loss. In this study, we examined the effectiveness of this technology compared with standard clinical care in reducing thrombosis-related graft loss and the requirement for color duplex ultrasonography in the first 24 hours postoperatively by a medical literature search of the application of this technology in kidney transplantation.

Materials And Methods: We conducted a systematic search (January 15, 2024) of a wide range of experimental and observational studies that comprised kidney transplant recipients monitored with blood flow sensing technology (intervention group) and standard clinical care (control group).

Clinical efficacy and safety of IV ferric carboxymaltose in restless legs syndrome: A meta-analysis of 537 patients.

Background: Recent research indicates that intravenous ferric carboxymaltose (IV FCM) presents a promising solution for Restless Legs Syndrome (RLS), distinguishing itself from other iron sources with minimal to no adverse effects. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety profile of administering IV FCM in patients with RLS, assuming that RLS and Iron deficiency anemia (IDA) are correlated.

Methodology: This study was conducted according to the PRISMA guideline, with search conducted on PubMed, Google Scholar, and the Medline library.

Exploring Faculty Preparedness for Artificial Intelligence-Driven Dental Education: A Multicentre Study.

Introduction In the modern era, technology, including artificial intelligence (AI), is the centre of digital innovation. AI is revolutionising numerous fields, including the healthcare sector, globally. Incorporating AI in dental education may help in improving the diagnostic accuracy, learners' experiences, and effectiveness of the management of dental education institutions.

Shining a Spotlight on Stigma: Exploring Its Impact on Oral Health-Seeking Behaviours Through the Lenses of Patients and Caregivers.

Introduction The unique nature of a lack of good oral health, coupled with the lack of discussion and recognition surrounding the associated stigma, highlights it as a distinct issue. This stigma causes discomfort, devalues individuals, and necessitates urgent care and intervention. In Pakistan, a variety of reasons, including cultural beliefs, socioeconomic gaps, and poor access to dental care services, tend to exacerbate the stigma that is associated with dental care.

Emerging trends in metal oxide-based electronic noses for healthcare applications: a review.

An electronic nose (E-nose) is a technology fundamentally inspired by the human nose, designed to detect, recognize, and differentiate specific odors or volatile components in complex and chaotic environments. Comprising an array of sensors with meticulously designed nanostructured architectures, E-noses translate the chemical information captured by these sensors into useful metrics using complex pattern recognition algorithms. E-noses can significantly enhance the quality of life by offering preventive point-of-care devices for medical diagnostics through breath analysis, and by monitoring and tracking hazardous and toxic gases in the environment.

Advances in flame synthesis of nano-scale architectures for chemical, biomolecular, plasmonic, and light sensing.

Flame spray pyrolysis (FSP), a key technique under the broader category of flame aerosol synthesis, is being increasingly explored for the design of advanced miniaturized sensor architectures with applications including chemical, biomolecular, plasmonic, and light sensing. This review provides an overview of the advantages of FSP for the fabrication of nanostructured materials for sensing, delving into synthesis strategies and material structures that meet the increasing demands for miniaturized sensor devices. We focus on the fundamentals of FSP, discussing reactor configurations and how process parameters such as precursor compositions, flow rates, and temperature influence nanoparticle characteristics and their sensing performance.

Students' Perception of Online Versus Face-to-Face Learning: What Do the Healthcare Teachers Have to Know?

During the COVID-19 pandemic, educational institutions confronted the possibility of complete closure and took countermeasures by adapting e-learning platforms. The present cross-sectional study quantified the impact of the pandemic on medical education using a validated and reliable tool. The tool was used to explore the perceptions of 270 healthcare students about e-learning in comparison to traditional learning systems.

The effect of colchicine on cholesterol crystal formation, expansion and morphology: a potential mechanism in atherosclerosis.

Background: Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Thus, agents that affect CC formation, expansion, and morphology may reduce cardiovascular (CV) risk independent of lipid-lowering and anti-inflammatory therapy.

Cholesterol crystals induce mechanical trauma, inflammation, and neo-vascularization in solid cancers as in atherosclerosis.

Background And Aims: Cancer and atherosclerosis share common risk factors and inflammatory pathways that promote their proliferation via vascular endothelial growth factor (VEGF). Because CCs cause mechanical injury and inflammation in atherosclerosis, we investigated their presence in solid cancers and their activation of IL-1β, VEGF, CD44, and Ubiquityl-Histone H2B (Ub-H2B), that promote cancer growth.

Methods: Tumor specimens from eleven different types of human cancers and atherosclerotic plaques were assessed for CCs, free cholesterol content and IL1-β by microscopy, immunohistochemistry, and biochemical analysis.

Impact of thermal radiation and internal heat generation on Casson nano-fluid flowing by a curved stretchable surface with suspension of carbon nanotubes (CNTs).

The function of present work is to inspect heat transmission of radiative nanofluid in regard to boundary layer description. Carbon nanotubes (CNTs) dependent fluid is being evaluated and it flows overtop a curved stretching surface. Special features, like thermal radiation and internal heat generation, which corresponds to heat transmission along the flow have been incorporated.

Deep Learning Techniques for Vehicle Detection and Classification from Images/Videos: A Survey.

Detecting and classifying vehicles as objects from images and videos is challenging in appearance-based representation, yet plays a significant role in the substantial real-time applications of Intelligent Transportation Systems (ITSs). The rapid development of Deep Learning (DL) has resulted in the computer-vision community demanding efficient, robust, and outstanding services to be built in various fields. This paper covers a wide range of vehicle detection and classification approaches and the application of these in estimating traffic density, real-time targets, toll management and other areas using DL architectures.

Exploring Views and Expectations of Clinicians, Nurses, and Kidney Transplant Recipients Regarding Protocol Development of a Study to Investigate Feasibility of the Implantable Doppler Probe in Kidney Transplantation: Patient-Public Involvement Consultations.

Objectives: The shortage of donor organs is the most limiting factor in kidney transplant practice today. New monitoring technologies are being investigated to reduce graft loss due to vascular complications. We assessed the feasibility of a novel blood flow monitoring device, the implantable Doppler probe, in kidney transplant surgery.

Synthesis and Characterization of Hydroxyethyl Cellulose Grafted with Copolymer of Polyaniline and Polypyrrole Biocomposite for Adsorption of Dyes.

The emerging concepts of sustainable textiles and controlled production strategy demands ideally zero emissions of contaminants into the aquatic environment. However, the currently in-practiced conventional processes in textiles dispose of a number of contaminants especially super toxic synthetic dyes as effluents. In recent years, nanomaterials have become attractive choice for eco-friendly removal of organic dyestuff.

Acute Kidney Injury In Hospitalized Covid-19 Patients: A Retrospective Observational Study.

Background: Published studies have reported that acute kidney injury (AKI) and other kidney related manifestations are associated with COVID-19 and linked with poor outcome. This study aimed to determine the incidence, risk factors and outcomes of AKI in hospitalized COVID-19 patients.

Methods: This retrospective study of 154 patients involved retrieving data from hospital records confirm COVID-19 infection admitted to the Northwest General Hospital & Research Center, Peshawar from 1st April to 31st July 2020.

The Comparative Pharmaco- and Histokinetics of the Therapeutic Dose of Estradiol Valerate and Bromocriptine in Common Quails.

The current study is aimed at examining the overall effects of steroids on the tissues of organisms and pharmacotherapeutics and pharmaco-histokinetics of several steroids, including Bromocriptine as mesylate and estradiol valerate in common quails (). A total of 100 birds were used for pharmaco-histokinetics. The research was carried out in two separate trials, one during the fall season and the other during the spring season.

Quantifying the Soil Arthropod Diversity in Urban Forest in Dera Ghazi Khan.

Arthropods can be either large or too small to be seen from the microscope. Their legs are jointed and perform a specific function in the soil. Several arthropods have been identified to date.

Immune Tolerance vs. Immune Resistance: The Interaction Between Host and Pathogens in Infectious Diseases.

The immune system is most likely developed to reduce the harmful impact of infections on the host homeostasis. This defense approach is based on the coordinated activity of innate and adaptive immune system components, which detect and target infections for containment, killing, or expulsion by the body's defense mechanisms. These immunological processes are responsible for decreasing the pathogen burden of an infected host to maintain homeostasis that is considered to be infection resistance.

Application of region-based video surveillance in smart cities using deep learning.

Smart video surveillance helps to build more robust smart city environment. The varied angle cameras act as smart sensors and collect visual data from smart city environment and transmit it for further visual analysis. The transmitted visual data is required to be in high quality for efficient analysis which is a challenging task while transmitting videos on low capacity bandwidth communication channels.

Glomerular Filtration Rate Estimation With Commonly Used Methods Among Healthy Live Kidney Donors of South Punjab, Pakistan.

Background Accurate estimation of the donor's glomerular filtration rate (GFR) is crucial for not only ensuring the medical appropriateness of the donor but also for the prediction of future allograft performance. The aim of this study was to compare the GFR estimation formulas and 24-hour urine creatinine clearance with diethylene triamine pentaacetic acid (DTPA) renal scan GFR. Methods This cross-sectional study was done at the Department of Nephro Urology Dialysis & Renal Transplantation, Bahawal Victoria Hospital, Quaid e Azam Medical College, Bahawalpur, Pakistan from September 2018 to September 2021.

The therapeutic effect of bromocriptine as mesylate and estradiol valerate on serum and blood biochemistry of common quails.

Hematology and serum biochemistry study may provide antique knowledge about the physical status of individuals, making them a valuable tool to differentiate healthy animals from affected animals. We aimed to investigate Steroid safety levels in birds through ex-situ studies at regular therapeutic doses. A total of 100 birds were used for hematology and serum biochemistry.

Successful treatment of severe COVID-19 pneumonia and hyperinflammatory syndrome with tocilizumab.

As of 28 October 2020, there are over 44 000 000 confirmed COVID-19 infections and over 1 000 000 deaths worldwide, including 945 367 infections and 45 765 deaths in the UK. Acute respiratory distress syndrome occurs in 50% of patients with secondary haemophagocytic lymphohistiocytosis, a hyperinflammatory syndrome characterised by a surge of cytokines, including interleukin 6 (IL-6). Here we describe the case of the first patient with severe COVID-19 pneumonia successfully treated with tocilizumab, a humanised monoclonal antibody against the IL-6 receptor, in the UK.

Dynamics and conformational propensities of staphylococcal CntA.

Enzymes use transition metals as co-factors for catalytic roles in biological processes. Notably, manganese, iron, cobalt, nickel, copper and zinc are abundantly used. a commensal bacterium asymptomatically, lies on the human body causing variety of infections.