Publications by authors named "Zain Tirmizi"
Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal components in many types of cancer. CAFs contribute to hallmarks of cancer such as proliferation, invasion and immunosuppressive tumor microenvironment, and are associated with poor prognosis of patients with cancer. However, in glioblastoma (GBM), the most common and aggressive primary malignant brain tumor, our knowledge about CAFs or CAF-like stromal cells is limited.
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- * Local delivery of the NAMPT inhibitor GMX1778 led to significant immunological changes in the tumor, such as increased T cell recruitment and decreased immunosuppressive macrophages, enhancing the anti-tumor immune response.
- * Combining NAMPT inhibition with PD-1 checkpoint blockade showed improved survival in GBM-affected mice, suggesting a new immunotherapy strategy that targets both the tumor and the immune environment effectively.