Otolaryngologic Side Effects of GLP-1 Receptor Agonists.

Objectives: With the increasing use of GLP-1 receptor agonist (GLP-1 RA) drugs for weight loss and diabetes management, concerns have been raised regarding their potential side effects. We aim to assess the frequency of otolaryngologic adverse events (AEs).

Study Design: Retrospective analysis of national registry.

Dual Open Atom Interferometry for Compact and Mobile Quantum Sensing.

We demonstrate an atom interferometer measurement protocol compatible with operation on a dynamic platform. Our method employs two open interferometers, derived from the same atomic source, with different interrogation times to eliminate initial velocity dependence while retaining precision, accuracy, and long term stability. We validate the protocol by measuring gravitational tides, achieving a precision of 4.

Viral infection as an inciting event for development of chronic rhinosinusitis: A population-based study.

Viral infections lead to a greater than twofold increased risk of developing chronic rhinosinusitis within 1 year. Viral infections lead to a greater than twofold increased risk of developing chronic rhinosinusitis within 1 year. Recurrent viral infections pose a greater risk of chronic rhinosinusitis than single episodes.

Fundamental Limits of Feedback Cooling Ultracold Atomic Gases.

We investigate the fundamental viability of cooling ultracold atomic gases with quantum feedback control. Our Letter shows that the trade-off between the resolution and destructiveness of optical imaging techniques imposes constraints on the efficacy of feedback cooling, and that rapid rethermalization is necessary for cooling thermal gases. We construct a simple model to determine the limits to feedback cooling set by the visibility of density fluctuations, measurement-induced heating, and three-body atomic recombination.

Endoscopic procedures in hepatology: Current trends and new developments.

Gastrointestinal endoscopy has long been a reliable backbone in the diagnosis and management of hepatobilary disorders and their complications. However, with evolving non-invasive testing, personalised medicine has reframed the utility and necessity of endoscopic screening. Conversely, the growing interest and use of endoscopic ultrasound (EUS) and advanced endoscopy within gastrointestinal units has also opened novel diagnostic and therapeutic avenues for patients with various hepatobiliary diseases.

Clopidogrel Is Associated with Reduced Likelihood of Aneurysmal Subarachnoid Hemorrhage: a Multi-Center Matched Retrospective Analysis.

Maladaptive inflammation underlies the formation and rupture of human intracranial aneurysms. There is a growing body of evidence that anti-inflammatory pharmaceuticals may beneficially modulate this process. Clopidogrel (Plavix) is a commonly used irreversible P2Y12 receptor antagonist with anti-inflammatory activity.

Signatures of Quantum Gravity in the Gravitational Self-Interaction of Photons.

We propose relativistic tests of quantum gravity using the gravitational self-interaction of photons in a cavity. We demonstrate that this interaction results in a number of quantum gravitational signatures in the quantum state of the light that cannot be reproduced by any classical theory of gravity. We rigorously assess these effects using quantum parameter estimation theory and discuss simple measurement schemes that optimally extract their signatures.

Increased prevalence of blister aneurysm formation during the COVID-19 pandemic.

Background: Intracranial blister aneurysms are a rare and an historically difficult to treat subset of aneurysms. They are distinct from typical saccular aneurysms with different pathophysiology and treatment options.

Methods: A prospectively maintained database of subarachnoid hemorrhage patients was queried for those presenting prior to the pandemic (2017-2019), and those presenting during the height of the pandemic in our locality (2021).

Increased Concentrations of Atherogenic Proteins in Aneurysm Sac Are Associated with Wall Enhancement of Unruptured Intracranial Aneurysm.

Current MR-vessel wall imaging (VWI) of unruptured intracranial aneurysms (UIAs) permits the visualization of wall structures. Aneurysm wall enhancement (AWE) was associated with atherosclerotic remodeling of the aneurysm wall accompanied by infiltration of inflammatory cells, potentially contributing to rupture. This study sought to investigate whether the luminal concentrations of atherosclerotic proteins in the aneurysm sac were associated with increased wall enhancement of UIAs in VWI.

Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy.

Interest in the use of pharmacological ascorbate as a treatment for cancer has increased considerably since it was introduced by Cameron and Pauling in the 1970s. Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation sensitizer in cancer. The results of these studies are promising.