Publications by authors named "Zain A Karamya"

Background/objectives: Loss-of-function chymotrypsin C (CTRC) variants increase the risk for chronic pancreatitis (CP) by reducing protective pancreatic CTRC activity. Variants in the 5' upstream region that includes the promoter might affect CTRC expression but have not been investigated to date. The aim of the present study was to address this knowledge gap.

View Article and Find Full Text PDF
Article Synopsis
  • Autoimmune pancreatitis (AIP) is often mistaken for pancreatic cancer, making diagnosis difficult, especially in cases requiring surgical intervention like pancreatic resection.
  • A meta-analysis reviewed 10 studies, finding that 1.6% (140 cases) of patients who underwent pancreatic resection for suspected cancer actually had AIP, with 94% being type 1 AIP.
  • The study highlights that current diagnostic methods are inadequate, as serum CA 19-9 levels do not effectively differentiate between AIP and pancreatic ductal adenocarcinoma (PDAC), leading to the risk of unnecessary surgeries.
View Article and Find Full Text PDF

Understanding antigen-specific T-cell responses, for example, following virus infections or allergen exposure, is of high relevance for the development of vaccines and therapeutics. We aimed on optimizing immunophenotyping of T cells after antigen stimulation by improving staining procedures for flow and mass cytometry. Our method can be used for primary cells of both mouse and human origin for the detection of low-frequency T-cell response using a dual-barcoding system for individual samples and conditions.

View Article and Find Full Text PDF