Publications by authors named "Zaihong Hu"
Article Synopsis
- This study investigates prognostic factors for Wilms tumor (WT) using peripheral blood cell profiling, addressing a gap in evaluation methods despite effective treatment strategies.
- It finds significant differences in blood cell counts between WT and non-WT children, with specific indices affecting overall survival (OS) and event-free survival (EFS).
- Key independent prognostic factors identified include lower M levels and stage IV disease, which were validated through statistical analysis and a nomogram, indicating their potential as predictive markers for WT outcomes.
Neuroblastoma (NB), a common and highly lethal malignant disease in pediatrics, still lacks an effective therapeutic approach that addresses all conditions. Immunogenic Cell Death (ICD) plays a crucial role in tumor cell death and triggers a potent anti-tumor immune response. In this study, we report an ICD-related index (ICDR-Index) in NB through various machine learning methodologies, utilizing bulk transcriptome data from 1244 NB samples and 16 scRNA-seq datasets.
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