The Diagnostic Value of Gene Detection Combined with DNA Ploidy Analysis in Thyroid Cancer.

Background: The thyroid cancer incidence has been experimenting an accelerated growth all over the world. The serine/threonine-protein kinase () gene detection or the DNA ploidy analysis has been employed in the identification of thyroid cancer type. This study aimed to evaluate the diagnostic value of the gene integrated with DNA ploidy analysis in thyroid cancer.

Triptolide ameliorates osteoarthritis by regulating nuclear factor kappa B-mediated inflammatory response.

Objectives: Osteoarthritis (OA) is a joint degenerative disease that commonly occurs in older people and affect the quality of life. Triptolide (TPL), a compound derived from Tripterygium wilfordii, has been shown to exhibit anti-inflammatory properties. Here, we investigated the therapeutic effect of TPL on the experimental OA as well as the underlying molecular mechanisms.

Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis.

Blockade of Hedgehog signaling can prevent osteoarthritis (OA) syndromes. However, the amelioration of related inflammation condition is limited. The purpose of this study was to observe the effect of combined use of Hedgehog signaling inhibitor GANT-61 and common clinical anti-inflammatory drug indomethacin on cartilage injury and inflammation in experimental OA mice.