Publications by authors named "Zaid Haque"
Spinocerebellar ataxia type 3 (SCA3) is the most common dominantly inherited ataxia. Currently, no preventive or disease-modifying treatments exist for this progressive neurodegenerative disorder, although efforts using gene silencing approaches are under clinical trial investigation. The disease is caused by a CAG repeat expansion in the mutant gene, ATXN3, producing an enlarged polyglutamine tract in the mutant protein.
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- Spinocerebellar ataxia Type 3 (SCA3) is the most common inherited ataxia caused by a CAG repeat expansion leading to a mutant ATXN3 protein, with no effective therapies available.
- Research indicates that oligodendrocytes, not just neurons, play a significant role in the disease's neurodegeneration, particularly affecting brain regions like the cerebellum and brainstem.
- Findings show that impairment in oligodendrocyte maturation is a crucial mechanism of SCA3, suggesting the need for new therapeutic strategies that address both neuronal and non-neuronal aspects of the disease.