Publications by authors named "Zaichick V"

Frequently knowledge of elemental content of human organs and tissues is required for a variety of applications. These can include brachytherapy and radiotherapy planning, radiation dosimetry and radiation protection. Revised reference values of chemical element mass fractions in normal and cancerous prostate tissues of the Reference (European Caucasian) Man are suggested as a result of this work.

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The prostate gland is subject to various disorders. The etiology and pathogenesis of these diseases are not well understood. Moreover, despite technological advancements, the differential diagnosis of prostate disorders has become progressively more complex and controversial.

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Objective: The aim of this study was to clarify the differences between the prostatic levels of chemical elements in patients with benign prostatic hyperplasia (BPH) and healthy male.

Methods: We evaluated the prostatic level of 66 chemical elements in 43 patients with BPH and 37 healthy males. Measurements were performed using five instrumental analytical methods.

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Background: It is unclear why a prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of trace element contents in thyroid may play important role in goitre- and carcinogenesis of gland.

Aim: To examine the variation with age of the mass fraction of 50 trace elements in intact (normal) male thyroid.

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To clarify age-related changes of 67 macro- and microelement contents in prostate gland of adult and geriatric males, a quantitative measurement by five analytical methods was performed. The nonhyperplastic prostate glands of 65 subjects (European-Caucasian aged 21-87 years) were investigated by energy dispersive X-ray fluorescence (EDXRF), instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides (INAA-SLR), instrumental neutron activation analysis with high resolution spectrometry of long-lived radionuclides (INAA-LLR), inductively coupled plasma atomic emission spectrometry (ICP-AES), and inductively coupled plasma mass spectrometry (ICP-MS). The prostates were obtained at autopsy from subjects who died from acute illness (cardiac insufficiency, stroke, embolism of pulmonary artery, alcohol poisoning) and trauma.

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In order to clarify the differences between Ag, Br, Ca, Co, Cr, Fe, Hg, K, Mg, Mn, Na, Rb, Sb, Sc, Se, and Zn contents in hyperplastic (patients with benign prostate hyperplasia (BPH), n = 32) and nonhyperplastic (control group of healthy male inhabitants, n = 32) prostates, an instrumental neutron activation analysis was performed. Mean values (M ± SΕΜ) for mass fraction (mg/kg, dry mass basis) of chemical elements in glands of patients with BPH were the following: Ag, 0.0346 ± 0.

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Several experiments show that prostatic fluid is continuously produced and it is drained from the prostate during urination and ejaculation. The mechanism which causes prostatic fluid to drain from the prostatic acini during urination is currently unclear. Also in current opinion such structures of the prostatic urethra as the urethral crest and the colliculus seminalis have no apparent functional significance.

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The Ca, Cl, Mg, Na, and P contents and Ca/P, Ca/Mg, Ca/Na, Cl/Ca, and Cl/Na ratios in samples of intact bone, inflamed bone, and Ewing's sarcoma tissue were investigated by neutron activation analysis with high-resolution spectrometry of short-lived radionuclides. In Ewing's sarcoma tissue, the mass fractions of Cl and Na are higher and the mass fractions of Ca and Mg are lower than those of both normal and inflamed bone tissues. It was shown that the levels of Ca and Cl mass fractions and also levels of the Ca/Cl and Cl/Na ratios can be used as an additional test for differential diagnosis between inflamed (or normal) bone and Ewing's sarcoma.

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The variation with age of the mass fraction of 37 chemical elements in intact nonhyperplastic prostate of 65 healthy 21-87 year old males was investigated by instrumental neutron activation analysis with high resolution spectrometry of short- and long-lived radionuclides. Mean values (M±SΕΜ) for mass fractions (mg kg(-1), dry mass basis) of the chemical elements studied were: Ag-0.055±0.

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The variation with age of the 18 trace element mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0-30 years was investigated by instrumental neutron activation analysis, inductively coupled plasma atomic emission spectrometry, and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet tissue) of these trace elements in pre-puberty were: Al 28.5 ± 9.

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The variation with age of the Br, Fe, Rb, Sr, and Zn mass fractions and some histological characteristics of intact prostate glands of 50 subjects aged 0-30 years was investigated by an energy-dispersive X-ray fluorescence and a quantitative morphometric analysis. Mean values ± standard error of the mean (M ± SΕΜ) for the mass fractions (in milligrams per kilogram wet-mass basis) of these trace elements in pre-puberty were: Br-10.5 ± 1.

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The effect of age on the mass fraction of 19 chemical elements in the intact prostate of 50 apparently healthy 0-30-year-old males was investigated by neutron activation analysis with high-resolution spectrometry of short-lived radionuclides and inductively coupled plasma atomic emission spectrometry. Mean values (M ± standard error of the mean) for mass fraction (in milligrams per kilogram, on dry weight basis) of chemical elements were as follows: Al, 77 ± 17; B, 1.31 ± 0.

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The effect of age on chemical element mass fractions in intact prostate of 50 apparently healthy 0-30 year old males was investigated by neutron activation analysis with high resolution spectrometry of short-lived radionuclides. Mean values (M ± SΕΜ) for mass fraction (mgkg(-1), dry mass basis) of chemical elements before the time of puberty and in the period of puberty and post-puberty were: Br 46.0 ± 6.

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To clarify age-related histological and Zn content changes in nonhyperplastic adult prostate glands, a quantitative morphometric and energy-dispersive X-ray fluorescence analyses were performed. The prostates were obtained from autopsies of 63 subjects aged 21-70 years who died mainly from trauma. It was found that histologically normal prostate tissue undergoes substantial changes throughout aging.

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The mass fractions (in milligrams per kilogram given on a dry mass basis) of 69 chemical elements in the intact rib bone of 84 apparently healthy 15- to 58-year-old citizens (38 females and 46 males) of a nonindustrial region were investigated using five instrumental analytical methods: neutron activation analysis with high-resolution spectrometry of short- and of long-lived radionuclides, particle-induced gamma-ray emission spectrometry, inductively coupled plasma atomic emission, and mass spectrometry. The mass fractions of chemical elements were measured for rib bone of both males and females, taken separately and together. The present results indicate that rib bone can be used as exposure monitors in occupational medicine and environmental health studies to assess, or indicate, the body burden of Al, B, Ba, Be, Ca, Cr, F, Li, Mg, Na, Ni, P, Pb, rare-earth elements (REEs), Sr, and Zn.

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This study was undertaken to provide reference values of chemical element mass fractions in intact bone of Reference (European Caucasian) Man/Woman. The rib bone samples investigated were obtained from autopsies of 84 apparently healthy 15-58-year-old citizens (38 females and 46 males) of a non-industrial region in the Central European part of Russia who had suffered sudden death. The mass fractions (mg/kg given on a wet mass basis) of 69 elements in these bone samples were measured by using neutron activation analysis with high-resolution spectrometry of short-lived and long-lived radionuclides, particle-induced gamma-ray emission, inductively coupled plasma atomic emission spectrometry, and inductively coupled plasma mass spectrometry including necessary quality control measures.

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To clarify age-related histological and zinc content changes in paediatric and nonhyperplastic young adult prostate glands, a quantitative morphometric and energy-dispersive X-ray fluorescence analysis (EDXRF) was performed. The prostates were obtained at autopsy from 50 subjects (European-Caucasian aged 0-30 years) who died from sudden infant death syndrome, acute pulmonary aetiologies and trauma. None of the subjects had any symptoms of prostatic disease and all prostates were classified as histologically normal.

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Contents of 52 trace elements in intact prostate of 64 apparently healthy 13-60-year-old men (mean age 36.5 years) were investigated by inductively coupled plasma mass spectrometry. Mean values (M ± SΕΜ) for mass fraction (in milligrams per kilogram, on dry-weight basis) of trace elements were as follows: Ag 0.

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The effect of age on 12 chemical element contents in intact prostate of 64 apparently healthy, 13-60-year-old men (mean age 36.5 years) was investigated by inductively coupled plasma atomic emission spectrometry. Mean values (M ± SΕΜ) for mass fraction (milligrams/kilogram, on dry weight basis) of Ba, Ca, Cu, Fe, K, Mg, Na, P, S, Sr, and Zn were: Ba 1.

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The Ag, Co, Cr, Fe, Hg, Rb, Sb, Sc, Se, and Zn contents in normal (n=37), benign hypertrophic (n=43), and cancerous tissues (n=60) of the human prostate gland were investigated by neutron activation analysis. Mean values (M±SΕΜ) for content (mg/kg, dry weight basis) of trace elements in the normal tissue were: Ag-0.048±0.

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The effect of age on trace element contents in intact prostate of 64 apparently healthy 13-60 years old men was investigated by neutron activation analysis. Mean values (M±SΕΜ) for content (mg/kg, dry weight basis) of trace elements were: Ag-0.057±0.

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For the first time, the contents of rare earth elements (REEs) in a rib bone of a healthy human were determined. The mean value of the contents of Ce, Dy, Er, Gd, La, Nd, Pr, Sm, Tb, and Yb (10 elements out of 17 total REEs), as well as the upper limit of means for Ho, Lu, Tm, and Y (4 elements) were measured in the rib bone tissue of 38 females and 42 males (15 to 55 years old) using inductively coupled plasma mass spectrometry (ICP-MS). We found age-related accumulation of REEs in the bone tissue of healthy individuals who lived in a non-industrial region.

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The effect of age and gender on 59 trace-element contents in rib bone of 80 apparently healthy 15-55-year-old women (n = 38) and men (n = 42) was investigated by inductively coupled plasma mass spectrometry. Mean values (M ± SΕΜ) for the mass fraction (milligrams per kilogram, on dry-weight basis) of Ba, Bi, Cd, Ce, Cu, Dy, Er, Gd, La, Li, Mn, Mo, Nd, Pb, Pr, Rb, Sm, Sr, Tb, Tl, U, Yb, and Zn for both female and male taken together were: Ba 2.5 ± 0.

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Project: To understand the role of major, minor, and trace elements in the etiology of bone diseases including osteoporosis, it is necessary to determine the normal levels and age-related changes of bone chemical elements.

Procedure: The effect of age and gender on 38 chemical element contents in intact iliac crest of 84 apparently healthy 15-55 years old women (n=38) and men (n=46) was investigated by neutron activation analysis.

Results: Mean values (M+/-SEM) for mass fraction (on dry weight basis) of Ca, Cl, Co, Fe, K, Mg, Mn, Na, P, Rb, Sr, and Zn for both female and male taken together were Ca - 169+/-3g/kg, Cl - 1490+/-43 mg/kg, Co - 0.

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The effect of age and gender on 38 chemical element contents in femoral neck of 85 apparently healthy 15-55-year-old women (n = 38) and men (n = 47) was investigated by instrumental neutron activation analysis. Mean values (M +/- SEpsilonMu) for mass fraction (on dry weight basis) of Ca, Cl, Co, Fe, K, Mg, Mn, Na, P, Sr, and Zn for both female and male taken together were: Ca 153 +/- 3 g/kg, Cl 1,188 +/- 48 mg/kg, Co 0.0039 +/- 0.

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