Fabrication and Performance Enhancement of Wood Liquefaction-Based Carbon Fibers Modified with Alumina Nanoparticles.

In this paper, alumina-modified wood liquefaction (AL-WP) was prepared by blending nano-alumina (AlO) into wood liquefaction phenolic resin (WP) using a co-blending method. Alumina-modified wood liquefaction protofilament fiber (AL-WPF) was obtained by melt-spinning, curing, and thermo-curing processes, which were followed by carbonization to obtain alumina-modified wood liquefaction carbon fiber (AL-WCF). This paper focuses on the enhancement effect of nano-alumina doping on the mechanical properties and heat resistance of wood liquefaction carbon fiber (WCF), explores the evolution of graphite microcrystalline structure during the high-temperature carbonization process, and optimizes the curing conditions of AL-WPF.

Preparation and Adsorption Performance of Walnut Waste-Based Magnetic Activated Carbon with High Specific Surface Area.

Magnetic activated carbon (MAC) derived from agricultural waste shows significant potential for the removal of norfloxacin (NOR) from wastewater. However, understanding the removal mechanisms, efficiency, and recyclability of MAC produced from walnut green husk and ferrocene for NOR remains a challenge. In this study, walnut green husk-based MAC (HQP-MC) was synthesized, and changes in surface functionality, mechanisms for NOR removal, and major influencing factors were investigated.

Novel antibiotics against without detectable resistance by targeting proton motive force and FtsH.

The increased prevalence of methicillin-resistant (MRSA) and its biofilms poses a great threat to human health. Especially, -related osteomyelitis was hardly cured even by conventional antibiotics combined with surgical treatment. The development of novel structural antibiotics is urgently needed.

FAM49B drives colorectal cancer progression by stabilizing c-Myc through NEK9 phosphorylation.

Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second leading cause of cancer mortality. FAM49B, a member of the FAM49 gene family, is a recently identified, evolutionarily conserved gene. Emerging studies indicate that FAM49B plays a role in various cancers, though its specific mechanism in CRC remains largely unexplored.

Exploring core symptoms of alcohol withdrawal syndrome in alcohol use disorder patients: a network analysis approach.

Background: Understanding the interplay between psychopathology of alcohol withdrawal syndrome (AWS) in alcohol use disorder (AUD) patients may improve the effectiveness of relapse interventions for AUD. Network theory of mental disorders assumes that mental disorders persist not of a common functional disorder, but from a sustained feedback loop between symptoms, thereby explaining the persistence of AWS and the high relapse rate of AUD. The current study aims to establish a network of AWS, identify its core symptoms and find the bridges between the symptoms which are intervention target to relieve the AWS and break the self-maintaining cycle of AUD.

Characteristics of after-discharges following compound muscle action potential or F-wave in primary peripheral nerve hyperexcitability syndrome.

Introduction/aims: F-wave testing frequently reveals after-discharges of varied morphologies in patients with primary peripheral nerve hyperexcitability syndrome (PNHS), although reports are scant. This study aimed to explore the morphological characteristics of the after-discharges during F-wave tests in PNHS, and to assess the association between after-discharges and the disease classification.

Methods: We conducted a retrospective analysis of patients diagnosed with PNHS between 2014 and 2022.

Epidemiological trends and mid-term to long-term outcomes of acetabular fractures in the elderly in China.

Purpose: To explore the epidemiological trends in acetabular fracture and report the mid-term to long-term clinical outcomes of the elderly treated with operation.

Methods: Retrospective study. Patients aged ≥ 14 years with operative treatment of the Acetabular fracture from Jan 2010 to Dec 2019 at a level-1 trauma centre were identified to analyze the epidemiological trends, and the difference in fracture patterns between young and elderly patients (≥ 60 years old) were compared.

[Research advances in the treatment of keloid with glucocorticoids].

As a first-line classical drug, glucocorticoids are used in most combination treatment regimens of keloid. However, there are issues such as poor treatment efficacy and recurrence of keloid after keloid was treated with glucocorticoids, which seriously affect the therapeutic effect. In recent years, many studies have explored the factors influencing the efficacy of glucocorticoids in treating keloid and the action mechanism of glucocorticoids from different perspectives.

Analysis and multiple index evaluation of SPO distribution of bone traction needles for pelvic fracture reduction.

For robot-assisted pelvic fracture reduction, at least two bone needles need to be inserted into the ilium of the affected pelvis, and the robot clamping device is connected with the bone needles. The biomechanical properties of the pelvic musculoskeletal tissues are different with the different Spatial Position and Orientation (SPO) of the bone needles. In order to determine the optimal SPO of bone needle pairs, the constraints between the bone needles and the pelvis are analyzed, and the SPO vectors of 150 groups bone needles are obtained by the KNN-hierarchical clustering method; a batch modeling method of bone needles with different SPO is proposed.

CBCT-based synthetic CT generated using CycleGAN with HU correction for adaptive radiotherapy of nasopharyngeal carcinoma.

This study aims to utilize a hybrid approach of phantom correction and deep learning for synthesized CT (sCT) images generation based on cone-beam CT (CBCT) images for nasopharyngeal carcinoma (NPC). 52 CBCT/CT paired images of NPC patients were used for model training (41), validation (11). Hounsfield Units (HU) of the CBCT images was calibrated by a commercially available CIRS phantom.

Histochemical assessment on osteoclasts in long bones of toll-like receptor 2 (TLR2) deficient mice.

Objective: Toll-like receptor 2 (TLR2), recognizes a wide variety of pathogen-associated molecular patterns such as lipopolysaccharides, peptidoglycans, and lipopeptides, and is generally believed to be present in monocytes, macrophages, dendritic cells, and vascular endothelial cells. However, no histological examination of osteoclasts, which differentiate from precursors common to macrophages/monocytes, has been performed in a non-infected state of TLR2 deficiency. The objective of this study was to examine the histological properties and function of osteoclasts in the long bones of 8-week-old male TLR2 deficient (TLR2) mice to gain insight into TLR2 function in biological circumstances without microbial infection.

Efficacy of acupuncture on repair of glial scars in rats with traumatic brain injury.

Objective: To explore the underlying mechanism of acupuncture on nerve repair by investigating its effect on the differentiation of glial cells and the repair of glial scars.

Methods: Sprague-Dawley rats were randomly allocated to three groups: normal group, model group, and acupuncture group. Acupuncture was applied at Renzhong (GV26), Baihui (GV20), Fengfu (GV16), Yamen (GV15) and Hegu (LI4) within 12 h after TBI modeling with a frequency of one session per day for 4 weeks.

A questionnaire to assess the health information literacy of patients with intermediate-stage chronic kidney disease.

Aim: To investigate the status and influencing factors of health information literacy in patients with intermediate-stage chronic kidney disease (CKD).

Design: A prospective clinical study.

Methods: We used a CKD health information literacy questionnaire to survey 130 patients with intermediate-stage CKD and valuate their health needs and health knowledge.

A Preliminary Study on the Morphological Changes of an NiTi-Shaped Memory Alloy Stent in the Vertebral Body.

Objective: At present, the most commonly used filler polymethyl methacrylate (PMMA) has the disadvantages of monomer toxicity, heat and leakage, and cannot be applied in young people. Therefore, finding a minimally invasive and good tissue-compatible alternative material has been a research hotspot in spine surgery in recent years. The aim of this study is to explore whether the memory alloy stent can avoid the complications of bone cement or not.

Comprehensive effects of grain-size modification of electrolytic manganese residue on deep dehydration performance and microstructure of sludge.

As the by-product accompanied by sewage treatment, sludge has complex composition and high moisture content, therefore, its reutilization and disposal are still a challenge. In this paper, five kinds of quartz sand conditioners with different particle sizes (denoted as QS1, QS2, QS3, QS4 and QS5, respectively) were used to explore the effect of particle size distribution of conditioners on sludge dewatering performance. The moisture content, capillary suction time (CST), time to filter (TTF), specific resistance of filtration (SRF), particle size distribution curve, pore distribution law, scanning electron microscopy, isothermal adsorption-desorption curve and extracellular polymeric substances distribution were employed to characterize the modified sludge and explore the improvement mechanism.

L007-0069 kills Staphylococcus aureus in high resistant phenotypes.

Staphylococcus aureus, a common gram-positive pathogenic bacterium, is a main cause of hospital infection. The prevalence rate of methicillin-resistant S. aureus (MRSA) has made its treatment difficult in recent decades.

Histochemical assessment of accelerated bone remodeling and reduced mineralization in Il-6 deficient mice.

Objectives: Interleukin-6 (IL-6) contributes to the regulation of functions in various tissues and organs. Even though IL-6 has been reported to modulate bone metabolism in previous studies, this finding is controversial. This study aims to evaluate the possible involvement of IL-6 in bone metabolism by examining the histological activity of osteoblasts and osteoclasts in the femora of Il-6 deficient (Il-6) mice.

Study on antibacterial effect of halicin (SU3327) against Enterococcus faecalis and Enterococcus faecium.

Enterococci are important pathogens of nosocomial infections and are increasingly difficult to treat due to their intrinsic and acquired resistance to a range of antibiotics. Therefore, there is an urgent need to develop novel antibacterial agents, while drug repurposing is a promising approach to address this issue. Our study aimed to determine the antimicrobial efficacy of halicin against enterococci and found that the minimum inhibitory concentrations (MIC) of halicin against different strains of Enterococcus faecalis and Enterococcus faecium ranged from 4 to 8 μg/ml.

Fetal Reduction Could Improve but Not Completely Reverse the Pregnancy Outcomes of Multiple Pregnancies: Experience From a Single Center.

Objective: To investigate the effectiveness and limitations of multifetal pregnancy reduction (MFPR) on the improvement of pregnancy outcomes of triplet or twin pregnancies conceived by fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

Methods: We performed a cohort study of women undergoing IVF or ICSI from 2002-2016 in reproductive center, women's hospital, Zhejiang University School of Medicine. The cohort included 502 women who underwent MFPR and 9641 non-reduced women.

Characterization of the volatile organic compounds produced from green coffee in different years by gas chromatography ion mobility spectrometry.

The effect of storage time on green coffee volatile organic compounds (VOCs) was studied by their separation head space solid-phase microextraction and identification gas chromatography-ion mobility spectrometry. In total, 38 kinds of VOCs, mainly composed of alcohols, aldehydes, esters and ketones, were identified. The fingerprint showed that the VOCs produced by green coffee in different years had obvious differences, especially, acrolein, 3-methylbutyl acetate, butanoic acid, heptan-3-ol, and so on, that could be used to predict the storage time.

Pharmacokinetic Characteristics of Siponimod in Healthy Volunteers and Patients With Multiple Sclerosis: Analyses of Published Clinical Trials.

This study aimed to investigate the pharmacokinetic characteristics of siponimod in healthy volunteers and patients with MS based on aggregated data from published clinical trials, and to explore the factors influencing siponimod exposure. A total of 476 siponimod plasma concentrations aggregated from 28 dosage groups (corresponding to 294 healthy volunteers and 207 patients with MS) were collected from published clinical trials. Population pharmacokinetic (PPK) analysis was performed using a nonlinear, mixed-effect modeling approach.

[Effects of transient receptor potential vanilloid type 4-specific activator on human vascular endothelial cell functions and blood supply of rat perforator flap and its mechanism].

To analyze the effects of transient receptor potential vanilloid type 4 (TRPV4) activation on the function and endothelial-to-mesenchymal transition (EndMT) of human umbilical vein endothelial cells (HUVECs), as well as to explore the effects of TRPV4 activation on blood perfusion and survival of rat perforator flap and the mechanism. The experimental research methods were used. The 3 to 6 passages of HUVECs were used for experiments and divided into 0.

[Clinical application of expanded internal mammary artery perforator flap combined with vascular supercharge in reconstruction of faciocervical scar].

To summarize the clinical experience of expanded internal mammary artery perforator (IMAP) flap combined with vascular supercharge in reconstruction of faciocervical scar. The retrospective observational study was conducted. From September 2012 to May 2021, 23 patients with postburn or posttraumatic faciocervical scars who met the inclusion criteria were admitted to Shanghai Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, including 18 males and 5 females, aged from 11 to 58 years, all of whom were reconstructed with expanded IMAP flaps.