Systematic analysis of the necroptosis index in pan-cancer and classification in discriminating the prognosis and immunotherapy responses of 1716 glioma patients.

Necroptosis is a programmed form of necrotic cell death that serves as a host gatekeeper for defense against invasion by certain pathogens. Previous studies have uncovered the essential role of necroptosis in tumor progression and implied the potential for novel therapies targeting necroptosis. However, no comprehensive analysis of multi-omics data has been conducted to better understand the relationship between necroptosis and tumor.

Integrative analysis to screen novel pyroptosis-related LncRNAs for predicting clinical outcome of glioma and validation in tumor tissue.

Background: Pyroptosis, also known as inflammatory necrosis, is a programmed cell death that manifests itself as a continuous swelling of cells until the cell membrane breaks, leading to the liberation of cellular contents, which triggers an intense inflammatory response. Pyroptosis might be a panacea for a variety of cancers, which include immunotherapy and chemotherapy-insensitive tumors such as glioma. Several findings have observed that long non-coding RNAs (lncRNAs) modulate the bio-behavior of tumor cells by binding to RNA, DNA and protein.

Effects of residual mulching films with different mulching years on the diversity of soil microbial communities in typical regions.

Polyethylene mulching film plays a critical role in agricultural production. To clarify the impact of residual film and microplastics on soil microorganisms, this study examined four cotton fields with different film coverage years in typical areas of Xinjiang and analyzed the changes in soil bacterial and fungal community structure and diversity under residual film and microplastics using high-throughput sequencing technology. The results showed that the residual film in the 0-150 mm soil layers and 150-300 mm soil layers at the same sampling point had spatial distribution characteristics of 60-70% and 30-40%, respectively.

Preparation and Photoluminescent Properties of Amino 2,1,3-Benzoxadiazoles (Am-BODs) with D-A-D and D-A-A Conjugation Systems.

A series of D-A-D and D-A-A conjugated compounds composed of a benzoxadiazole core and corresponding amino moiety were synthesized. Their photoluminescent properties in different states were investigated as well. In the solution state, some compounds were observed to possess the usual anti-Kasha's emission in toluene and the solvatofluorochromic phenomenon.

Syntheses of 4-allyl-/4-allenyl-4-(arylthio)-1,4-dihydroisoquinolin-3-ones the photochemical Doyle-Kirmse reaction.

Facile synthesis of 4-allyl-/4-allenyl-4-(arylthio)-1,4-dihydroisoquinolin-3-ones via the visible-light-induced Doyle-Kirmse reaction of 4-diazo-1,4-dihydroisoquinolin-3-ones with allyl-/propargyl sulfides is reported. The reaction proceeds via the generation of free carbenes from cyclic diazo compounds followed by in situ formation of sulfonium ylide intermediates, which subsequently undergo [2,3-sigmatropic rearrangement] to give highly functionalized dihydroisoquinolinones in moderate to good yields. Broad substrate scope, and catalyst-free and mild conditions are the merits of this reaction.

Photocatalytic Approach for Construction of 5,6-Dihydroimidazo[2,1-]isoquinolines and Their Luminescent Properties.

A visible-light-driven photoredox reaction of tetrahydroisoquinoline with 2-azirines is described. 4,7-Bis(4-methoxyphenyl)benzo[][1,2,5]thiadiazole, a benzothiadiazole (BTD) derived fluorophore, is used as an organic photoredox catalyst, and the reaction offers an efficient access to 5,6-dihydroimidazo[2,1-]isoquinolines with a broad range of functional groups. The resulting 5,6-dihydroimidazo[2,1-]isoquinolines present strong photoluminecence in solutions and powders and could be applied in the fabrication of blue OLED devices.

Base Promoted Three-Component Annulation of 4-Diazoisochroman-3-imines with Dimethylsulfonium Ylides: Synthesis of Highly Functionalized Isochromeno[4,3-]pyridazines.

A novel method has been developed to synthesize a unique class of highly functionalized isochromeno[4,3-]pyridazines. This reaction features an intermolecular functionalization of terminal nitrogen atom of diazo group of 4-diazoisochoman-3-imine with two dimethylsulfonium ylide components, followed by a base promoted 6-exo-trig cyclization step. Readily available starting materials, a broad substrate scope, and operationally simple, mild, and catalyst-free reaction conditions are the prominent features of this method.

TfOH-promoted synthesis of 4,5-dihydrooxazolo[5,4-]isoquinolines formal [3 + 2] cycloaddition of 4-diazoisoquinolin-3-one and benzonitriles.

A facile and efficient method for the synthesis of novel 2-substituted 4-tosyl-4,5-dihydrooxazolo[5,4-c]isoquinolines from 4-diazoisoquinolin-3-ones and nitriles is reported. The reaction proceeded through a TfOH-promoted formal [3 + 2] cycloaddition and the products could be conveniently converted to 2-aryloxazolo[5,4-c]isoquinolines and the subsequent 2-(oxazolo[5,4-c]isoquinolin-2-yl)phenol which emitted bright green light in dilute dichloromethane solution and in solid form as well. Simple operation, metal-free and mild reaction conditions, short reaction time and broad substrate scope are the prominent features of this methodology.

Preparation and Photoluminescent Properties of Three 5-Amino Benzothiadiazoles (5-amBTDs).

Three D-A compounds were designed and synthesized based on a benzothiadiazole acceptor. Azepane (AP), iminodubenzyl (IDB) and iminostilbene (ISB) were used, respectively, as donors and installed on the 5-position of BTD to afford 1, 2 and 3, respectively. Their photophysical properties in different states (solution, film, crystal, and powder) are systematically investigated.

Preparation and photophysical properties of quinazoline-based fluorophores.

The donor-acceptor design is a classic method of synthesizing new fluorescent molecules. In this study, a series of new fluorescent compounds (1-10) were synthesized based on 2-(3,5-bis(trifluoromethyl)phenyl)-quinazoline acceptor and various amino donors. The fluorescent emissions of 1-10 cover the spectrum from 414 nm to 597 nm in cyclohexane solutions with various amino donors on 4- or 7-positions of quinazoline.

Copper-Carbene-Triggered Electrophilic Cyclization of o-Hydroxyarylenaminones with 3-Diazoindolin-2-imines: Synthesis of 3-Indolyl-4 H-chromen-4-ones and Pyrido[2,3- b:6,5- b']diindoles.

The Cu(II)-catalyzed electrophilic cyclization reaction between o-hydroxyarylenaminones and 3-diazoindolin-2-imines furnished 3-indolyl-4 H-chromen-4-ones in moderate to good yields with a broad substrate scope. Several pyrido[2,3- b:6,5- b']diindoles and one pyrazino[2,3- b:5,6- b']diindole were also obtained as byproducts in some cases and tested for their photophysical properties. Pyrido[2,3- b:6,5- b']diindoles exhibited solvent-dependent emission, while pyrazino[2,3- b:5,6- b']diindole emitted strong luminescence with 25.

Clinical Long-Term Follow-Up Evaluation of Functional Neuronavigation in Adult Cerebral Gliomas.

Objective: To assess the application of functional neuronavigation in surgeries of adult cerebral gliomas.

Methods: We performed a retrospective analysis of 375 cases of adult cerebral glioma patients who underwent microsurgical treatment between 2011 and 2017 in our department. Among them, 142 patients underwent surgery using functional neuronavigation (group A), and the other 233 patients were operated on without the help of functional neuronavigation (group B).

Rh-Catalyzed Conversion of 3-Diazoindolin-2-imines to 5H-Pyrazino[2,3-b]indoles with Photoluminescent Properties.

A rhodium-catalyzed reaction between 3-diazoindolin-2-imines and 2H-azirines, followed by treatment with a base, furnishes 5H-pyrazino[2,3-b]indoles in excellent yields. A number of functional groups tolerate the reaction conditions, and the resulting 5H-pyrazino[2,3-b]indoles present strong photoluminecence in solutions, powders, and films.

TfOH-Catalyzed Reaction between 3-Diazoindolin-2-imines and Electron-Rich Arenes: Access to 3-Aryl-2-aminoindoles.

TfOH-catalyzed reactions between 3-diazoindolin-2-imines and electron-rich arenes were disclosed. These metal-free reactions furnished 3-aryl-2-aminoindoles in moderate to excellent yields with the tolerance of a broad range of functional groups.

Microsurgical Outcomes After Gross Total Resection on Vestibular Schwannoma in Elderly Patients: A Matched Cohort Study.

Objectives: To compare and analyze the differences in clinical manifestations and surgical outcomes after gross total resection (GTR) for vestibular schwannoma between elderly and younger patients.

Methods: We conducted a retrospective study of 40 elderly (≥65 years) and 40 younger (<65 years) patients, and matched operation dates and tumor size in the 2 groups were matched. All 80 patients underwent microsurgical resection though the sigmoid approach, by the same surgeon (X.