Publications by authors named "ZaiXing Wang"

Article Synopsis
  • Researchers are exploring the role of stromal cells, such as fibroblasts, vascular endothelial cells (VECs), and smooth muscle cells (VSMCs), in the inflammation associated with psoriasis, a skin disease whose causes are not fully understood.
  • A comprehensive analysis of skin samples from psoriasis patients revealed distinct types of fibroblasts, VECs, and VSMCs that are more prevalent in lesional skin, indicating a shift towards inflammatory and angiogenesis-promoting activities in these cells.
  • The study concludes that the interactions between these stromal cells contribute to the pathological changes in psoriasis vulgaris, suggesting that targeting these cells may help improve the inflammatory environment associated with the disease.
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High performance film capacitor has attracted widespread attention due to their increasing applications in electronic devices. However, the insufficient dielectric properties of dielectrics in capacitors severely restrict their practical application. In this work, the dielectric performances of polyarylene ether nitrile (PEN) are effectively enhanced by the synthesizing and employing of carboxylated PEN (CPEN) modified one-dimensional (1D) strontium barium titanate nanorod (BSTNR) (CPEN@BSTNR), as well as applying of hot stretching technique.

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With the increasing application of electronic devices, absorption-dominated electromagnetic interference shielding materials (EMISM) have garnered significant attention for preventing secondary electromagnetic pollution. In this study, polyethyleneimine (PEI)-modified MXene (PEI@MXene) is fabricated and achieved its controlled distribution on the pore walls of polyarylene ether nitrile (PEN) porous films via the phase inversion method (PIM) to obtain a closed porous skeleton of MXene on the pore walls (CPS-MPW). The resulting PEI@MXene/PEN composite film (CFx) exhibited absorption-dominated EMIS efficiency (EMISE).

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Article Synopsis
  • Pemphigus vulgaris (PV) is a rare autoimmune skin disease, with its exact causes still not fully understood, prompting research into its underlying cellular mechanisms using advanced proteomic techniques like LC-MS/MS.
  • The study involved analyzing proteins extracted from skin biopsies of PV patients compared to healthy controls, identifying 880, 605, and 586 differentially expressed proteins across different skin conditions, with a particular focus on the activation of the oxidative phosphorylation (OXPHOS) pathway in keratinocytes.
  • Treatments with the OXPHOS inhibitor metformin and the JAK1 inhibitor tofacitinib showed promising effects by reducing cell separation caused by PV serum, underscoring the potential role of both the OXPH
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Article Synopsis
  • TMEM52B is a newly discovered tumor-related gene that is often overexpressed in nasopharyngeal carcinoma (NPC), correlating with more advanced cancer stages, higher recurrence rates, and shorter survival times.
  • Reducing TMEM52B expression decreases NPC cell growth, movement, and invasion, indicating its importance in cancer progression.
  • The gene produces two isoforms (TMEM52B-P18 and TMEM52B-P20) that differ in location and function; while both support cancer growth, TMEM52B-P20 specifically enhances metastasis by degrading E-cadherin, suggesting that targeting these isoforms might help develop new cancer treatments.
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Rationale: Patients who have myasthenia gravis or dermatomyositis show clinical signs of muscular weakening. Ocular muscle involvement is uncommon, and symmetrical proximal limb weakness is the typical presentation of dermatomyositis. However, the earliest and most noticeable sign in those with myasthenia gravis is extraocular muscular paralysis.

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To investigate the feasibility and clinical effect of the surgical approach and method of transnasal fenestration under nasal endoscope for the treatment of maxillary odontogenic cyst. The clinical data of 23 cases with maxillary odontogenic cysts treated by nasal endoscopy through nasal fenestration were retrospectively analyzed. All cases underwent nasal endoscopy and CT examination before the operation.

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Background: The pathogenesis of chronic spontaneous urticaria (CSU) is unclear, and it turned out to be involved in biological processes, such as autoimmunity, autoallergy, inflammation, and coagulation. The gut microbiota plays an important role in immune and inflammatory diseases. However, the relationship between chronic spontaneous urticaria and the gut microbiota remains unknown.

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Background: Image-guided system (IGS) has been gradually applied in the field of rhinology, making functional endoscopic sinus surgery (FESS) a truly minimally invasive and precise surgery. This study was based on real-world data from China hospitals and aimed to evaluate the clinical and economic benefits of the IGS navigation system in FESS.

Methods: This was a two-center retrospective chart review of patients with chronic rhinosinusitis who underwent FESS, including open frontal sinus between July 1, 2018 and December 31, 2019 in China.

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Background: Coronavirus disease-2019 (COVID-19) led to a global pandemic in March 2020 that has involved tens of millions of people. To date, prophylactic vaccines have been found to be the most effective method to contain the pandemic. Bullous pemphigoid (BP) is an autoimmune skin disease that mainly affects older individuals.

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In this paper, an InGaAs electron-hole bilayer tunnel field-effect transistor (EHBTFET) with a dual-metal left-gate and an N-pocket (DGNP-EHBTFET) is proposed and systematically studied by means of numerical simulation. Unlike traditional transverse EHBTFETs, the proposed DGNP-EHBTFET can improve device performance without sacrificing the chip density, and can simplify the manufacturing process. The introduction of the dual-metal left-gate and the N-pocket can shift the point-tunneling junction and adjust the energy band and the electric field in it, aiming to substantially degrade the OFF-state current () and maintain good ON-state performance.

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To observe the clinical efficacy of a multifunctional laser photoelectric platform combined with hydroxychloroquine in the treatment of l sensitive facia skin. A total of 226 patients with sensitive facial skin treated from March 2019 to November 2021 were randomly divided into two groups. Both groups were given an external moisturizer (shumin moisturizer) once in the morning and once in the evening as basic skin care treatment for the disease.

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In the present research, the synergistic effect of Arabic and guar gum inhibitors on the corrosion efficiency of concrete reinforcement was investigated. Thus, eight types of Arabic and guar gum combinations with 100, 250, 500, 750, and 1000 ppm were added to the steel reinforcement for 1, 7, 28, 48, and 72 days. The corrosion behavior of the samples was investigated by the electrochemical impedance (EIS) test.

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The incidence rate of nasopharyngeal carcinoma (NPC) is the highest among the malignant tumors of otorhinolaryngology, posing a huge burden to public health. Long noncoding RNAs (lncRNAs) exert an important role in tumorigenesis and the progression of various cancers. The present study found that HOXC-AS1 was highly expressed in NPC and in NPC cell lines, suggesting a critical role of HOXC-AS1 in NPC progression.

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We retrospectively analyzed the diagnosis and treatment process of one patient with recurrent undifferentiated pleomorphic sarcoma (UPS) of infratemporal fossa and made a definite diagnosis by combining the imaging and pathological examination results. After treatment failure with 2 cycles of chemotherapy and several surgeries, UPS was eventually treated by surgery + carbon ion radiotherapy, and MRI reexamination showed no relapse. Head and neck UPS is located deeply, easily recurs after operation, and difficult to be resected completely by surgery, with a gradually shortened interval of relapse over the number of surgeries, which becomes a treatment challenge.

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To investigate the feasibility of endoscopic nasolacrimal decompression for chronic dacryocystitis. 22 patients with chronic dacryocystitis hospitalized at Longgang ENT hospital were participated in this study. An injection of 30% iohexol was administered to conduct lacrimal sac angiography.

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Objective: Because of its vascular supply and neurovascular contents, the cavernous sinus (CS) is a challenging area to dissect in the setting of skull base tumors with intracavernous extension or invasion. In the present study, we report the clinical outcomes of 14 patients with tumors with CS invasion that were surgically treated using a direct transcavernous sinus approach for endoscopic endonasal resection of their intracavernous sinus tumors.

Methods: Fourteen patients had undergone surgery using a direct endoscopic endonasal transcavernous sinus approach.

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Aim: A genomic region on 5q33.3 lies between and encompasses the IL12B and PTTG1 genes, and contains many potential psoriasis causal variants. We aimed to further examine the influence of variants in and around this region.

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Anesthetic effect of remifentanil combined with propofol in awakening painless endoscopy was analyzed. Retrospective analysis of 120 cases of colon cancer were treated in Dongying People's Hospital from June 2015 to December 2017. All of them were treated by awakening painless digestive endoscopy, divided into 60 cases in observation group (combined with remifentanil and propofol anesthesia), and 60 cases in control group (combined intravenous anesthesia of finanib and propofol).

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Article Synopsis
  • Researchers conducted a genome-wide association study with 240 pemphigus vulgaris (PV) patients and 1,031 control individuals, discovering a significant genetic variant (rs11218708) linked to PV on chromosome 11q24.1.
  • They identified three key variants in the major histocompatibility complex region, showing strong associations with PV susceptibility and emphasizing immune response roles in the disease.
  • The study underscores the importance of genetic variants in autoimmune conditions like PV and demonstrates the effectiveness of advanced genetic analysis techniques in identifying susceptibility loci.
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Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of considerable genetic predisposition. Genome-wide association studies have identified tens of common variants for SLE. However, the majority of them reside in non-coding sequences.

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Researchers have learned that nearly all conditions and diseases have a genetic component. With the benefit of technological advances, many single-nucleotide polymorphisms (SNPs) have been found to be associated with the risk of complex disorders by using genome wide association studies (GWASs). Disease-associated SNPs are sometimes shared by healthy controls and cannot clearly distinguish affected individuals from unaffected ones.

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Dermatomyositis (DM) is a polygenic disorder characterized by inflammation of skeletal muscle and skin. To date, the exact etiopathogenesis of DM remains elusive. To explore the genetic basis of DM, we conducted genome-wide genotyping analysis of 127 patients and 1566 healthy controls by Illumina Human OmniZhongHua-8 BeadChips in the Chinese Han population.

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