Publications by authors named "Zai-Ling Yang"
Article Synopsis
- Reduced thymic epithelial cells (TECs) are linked to thymic degeneration, but umbilical cord mesenchymal stem cells (UCMSCs) have shown promise in restoring TEC function and structure despite the unclear mechanisms behind this effect.
- The study involved inducing senescence in TECs and then coculturing them with UCMSCs, which resulted in significant changes in gene expression, particularly in the PI3K-AKT signaling pathway.
- The findings suggest that UCMSCs enhance TEC proliferation by upregulating VEGFA and promoting key cell cycle proteins, ultimately reversing age-related dysfunction in TECs.
Background: The tumorigenesis of infused umbilical cord mesenchymal stem cells (UC-MSCs) is being preclinically evaluated.
Methods: We observed tumor formation in NOD SCID mice after a single subcutaneous injection of hUC-MSCs and the effect of these cells on tumor growth in tumor-bearing mice. Three generations (P5, P7, and P10) of hUC-MSCs (1 × 10) from two donors (hUC-MSC1 and hUC-MSC2) were inoculated subcutaneously into NOD SCID mice.
Article Synopsis
- The study investigates the effects of mouse umbilical cord mesenchymal stem cells (mUCMSCs) on the reproductive health of ageing C57 mice, focusing on their potential to repair ovarian function.
- Aging mice with diminished ovarian function received mUCMSC injections, resulting in increased ovarian size, the presence of follicles, and enhanced hormone levels compared to a control group.
- The findings indicate that mUCMSCs can reduce cell apoptosis and oxidative stress in granulosa cells by altering specific gene expressions and activating key cellular pathways, suggesting a potential for regenerative therapies in reproductive health.
Based on the characteristics of modern weapon injury, a repetitive model of traumatic systemic inflammatory response syndrome (SIRS) and an evaluation system were established. The models were treated with GFP-labeled tree shrew umbilical cord mesenchymal stem cells (UCMSCs). Forty out of 50 tree shrews were used to make a unilateral femoral comminuted fracture.
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