Publications by authors named "Zahran M"

Background: The Tie2/Ang pathway was found to be involved in forming tumor blood vessels in various tumors. The goal of this study was to evaluate the value of Tie2/Ang pathway as a novel biomarkers for the early detection of chronic hepatitis C virus (CHC)-related hepatocellular carcinoma (HCC). And the possibility of their future application in HCC treatment.

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Type 2 diabetes (T2D) is a chronic metabolic disorder caused by defective insulin signaling, insulin resistance, and impairment of insulin secretion. Autophagy is a conserved lysosomal-dependent catabolic cellular pathway involved in the pathogenesis of T2D and its complications. Basal autophagy regulates pancreatic β-cell function by enhancing insulin release and peripheral insulin sensitivity.

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Skin wounds can drive global impacts, socially and economically, in parallel with their elevated incidence rate. Therefore, utilizing the dual-activity of Brassica Oleracea (Red Cabbage) extract, of being pH-sensitive and biologically active in designing novel, therapeutic, and pH-sensitive wound dressings with an easily stripped-off feature, is critical. Wound dressings were designed using two separate hydrogels based on chitosan (CS) and hydroxyethylcellulose (HEC), each loaded with RCE.

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Early postnatal development is a critical period for the configuration of neural networks that support social and affective-like behaviors. In this sense, children raised in stressful environments are at high risk to develop maladaptive behaviors immediately or later in life, including anti-social and aggressive behaviors. However, the neurobiological bases of such phenomena remain poorly understood.

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Background: Defining the protective thresholds against the severe-acute-respiratory-syndrome-related corona virus-2 pandemic is a crucial challenge. To reduce the risks of severe disease, hospitalization, and death, various COVID-19 vaccines have been rapidly developed.

Aim Of The Work: This study aimed to assess the impact of three common COVID-19 vaccine types; two mRNA COVID-19 vaccines: (Pfizer/BioNTech's BNT162b2 and Moderna's mRNA-1273), one adenoviral vector vaccine: Oxford/AstraZeneca's ChAdOx1, and one inactivated vaccine (Sinovac Biotech/China's Sinovac) on the level of neutralizing antibodies, considering factors such as vaccine type, demographic characteristics, and hybrid immunity.

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Contamination by spent engine oil represents a significant global environmental challenge as it poses a major hazard to human health, animals, plants, microorganisms, the soil ecosystem, and aquatic ecosystems. This study assumes that some amendments differ significantly in their ability to degrade petroleum hydrocarbons. Therefore, this incubation study was conducted to investigate the effect of different types of inorganic and organic amendments (zeolite, bone char, banana leaves biochar, and wood chips biochar) on carbon emissions (CO-C) and the kinetics of total petroleum hydrocarbons (TPHC) degradation in artificial petroleum-contaminated soil.

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Introduction: The renin-angiotensin-aldosterone system (RAAS) plays a pivotal role in regulating blood pressure (BP), with dysregulation of RAAS resulting in hypertension and potentially heart failure (HF), myocardial infarction (MI), cardio-renal syndrome, and stroke. RAAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs), have advantages beyond BP control. However, differences between these two drug classes need to be considered when choosing a therapy for preventing cardiovascular events.

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Sweat is considered the most promising candidate to replace conventional blood samples for noninvasive sensing. There are many tools and optical and electrochemical methods that can be used for detecting sweat biomarkers. Electrochemical methods are known for their simplicity and cost-effectiveness.

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Background: The liver is crucial for maintaining normal metabolism in the body. Various substances, such as toxic chemicals, drugs, and alcohol, can damage hepatocyte cells, leading to metabolic imbalances.

Aim: The experiment aimed to determine the efficacy of seed oil (LSS) as a hepatoprotective agent against acute hepatotoxicity triggered by carbon tetrachloride (CCl).

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Article Synopsis
  • Alcohol withdrawal affects social behavior differently in male and female rodents, which can be measured using the three-chamber test; however, traditional automatic tracking methods often yield inaccurate results due to their inability to capture direct interactions.* -
  • The study utilized DeepLabCut, an AI-based pose-estimation toolkit, to score social behavior in mice during alcohol withdrawal and demonstrated that it could detect significant social deficits in female mice, contrary to results from conventional automatic tracking methods like AnyMaze.* -
  • Results indicated that DeepLabCut and manual scoring methods showed strong agreement and lower biases in analyzing social deficits during acute withdrawal, suggesting that this AI approach provides a more accurate assessment of social behavior compared to existing commercial tracking systems.*
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Background: Doxorubicin (DOX) is a chemotherapeutic drug applied clinically for the remedy of cancer, but its possibly life-threatening cardiotoxicity effects remain a concern.

Aim: After that, this study evaluates the cardioprotective impacts of (LSS) oil on DOX induced cardiomyopathy in rats.

Methods: Wistar male rats ( = 28, weighting 190-210 g) were arbitrarily allocated into four equal groups.

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Resin cement integrated with zein-incorporated magnesium oxide nanoparticles has previously been found to inhibit oral microbes and decrease bacterial biofilm. However, the bond strength and surface features of this biomaterial have yet to be investigated. The objective of this study was to evaluate the shear bond strength, mode of fracture, and surface roughness of resin cement modified with zein-incorporated magnesium oxide nanoparticles.

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Article Synopsis
  • Anaerobic co-digestion of paperboard sludge (PS) and sewage sludge (SS) enhances biogas production by finding the optimal mixing ratio of 50:50, resulting in a methane yield of 241.68 mL/g COD and improved conversion efficiencies for proteins, carbohydrates, and volatile fatty acids (VFAs).
  • The co-digestion process promotes the growth of beneficial bacteria that help convert complex organic matter into biomethane, mitigating issues like VFA accumulation and nutrient imbalances.
  • A combined system for anaerobic digestion and thermal treatment can produce biochar while generating significant profits from biogas and carbon credits, with a projected payback period of 6.60 years, though further research is still
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This multicentre retrospective study was conducted in 3 university hospitals in Egypt between April 2020 and June 2022. The aim was to assess the relation between Coronavirus Disease-19 (COVID-19) and ischemic priapism. Forty-three ischemic priapism patients were diagnosed and divided into two groups (30 in group I with ischemic priapism only, and 13 in group II with both ischemic priapism and COVID-19).

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Background: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) carries risk of complications and should be attempted when the anticipated benefits exceed the potential risks. The primary indication for CTO-PCI is symptom improvement. However, the impact of CTO-PCI on angina and subsequent incidence of major adverse cardiovascular event (MACE) rate remains controversial.

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Background: Anterior shoulder dislocation (ASD) is a frequently observed musculoskeletal injury that is often encountered in the context of sports activities or as a result of trauma. Several magnetic resonance imaging (MRI) parameters have been previously investigated for the purpose of characterizing the anatomical features, which could potentially be responsible for the episodes of instability. These measurements have the potential to identify patients who are susceptible to dislocation.

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Objective: To develop and internally validate a nomogram to predict recurrence-free survival (RFS) including the time to radical cystectomy (RC) and perioperative blood transfusion (PBT) as potential predictors.

Methods: Patients who underwent open RC and ileal conduit between January 1996 to December 2016 were split into developing (=948) and validating (=237) cohorts. The time to radical cystectomy (TTC) was defined as the interval between the onset of symptoms and RC.

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Key Clinical Message: Rare yet significant, this case sheds light on the uncommon presentation of Waldmann's disease in adults, showcasing the diagnostic challenges it poses. A multidisciplinary approach, integrating clinical, endoscopic, histological, and radiological evaluations, is crucial for accurate diagnosis and management. Further research is needed to deepen our understanding of this complex disorder.

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(Lamiaceae family) aerial parts extract contains 57 metabolites, including flavonoids, phenolic acids, anthocyanins, and coumarins, as assessed by UPLC-QTOF-MS/MS. Successive extracts (hexane, chloroform, ethyl acetate, ethanol 95%, and water) were tested cytotoxic activity against HepG-2, MCF-7, HCT-116, A549, and PC3 cell lines. The results revealed that hexane extract exhibited the most potent cytotoxic activity among PC3 and A549 cell lines, IC = 47.

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Article Synopsis
  • Parkinson's disease (PD) is caused by the degeneration of dopaminergic neurons, leading to various motor and non-motor symptoms, with GABA neurotransmission playing a key protective role against this degeneration.
  • Sleep disorders in PD, such as insomnia and fragmented sleep, are linked to reduced GABA levels, which can further exacerbate cognitive dysfunction and overall PD symptoms.
  • The review highlights the need for more prospective studies to better understand GABA's role in PD neuropathology, especially concerning sleep disorders, and suggests investigating GABA agonists as a potential treatment avenue.
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Unlabelled: Serum polymerase chain reaction (PCR) for the detection of DNA has been suggested for rapid Q fever diagnosis. We evaluated the role of PCR testing in serum in the diagnosis of acute Q fever in an endemic setting. We examined patients suspected of acute Q fever tested for -specific serum real-time PCR in a tertiary hospital between January 2019 toand December 2022.

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Key Clinical Message: Unilateral tongue atrophy can be a rare and crucial early indicator of metastatic prostate cancer, highlighting the need for vigilant monitoring in clinical assessments. This case underscores the importance of considering cranial nerve involvement, especially the twelfth, for timely intervention and comprehensive patient care.

Abstract: Prostate cancer, ranking among the most prevalent cancers, often manifests with skeletal metastases.

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Background: Cancer and cardiovascular diseases are the main causes of mortality worldwide. Although the incidence of cancer is rising, modern comprehensive management including surgery, chemotherapy, and radiotherapy led to decreased mortality, but also different cardiovascular complications. Conventional EF measurement fails to detect subtle changes in LV function, so a more sensitive tool is needed.

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Introduction And Importance: Hemangiomas, abnormal growths of vascular endothelial cells, are common vascular tumors in children. In contrast, their prevalence is 1-3 % in full-term newborns. Their unique location and associated complications can cause significant distress for patients and families.

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