Short and long-term immune changes in different severity groups of COVID-19 disease.

Background: There are limited data on short- versus long-term changes in adaptive immune response across different COVID-19 disease severity groups.

Methods: A multicenter prospective study of 140 adult patients with COVID-19 (a total of 325 samples) were analyzed for inflammatory markers and lymphocyte subsets at presentation, week 2, and week 24.

Results: Inflammatory markers at presentation were higher in the critical/severe than in moderate and mild groups.