Publications by authors named "Zahra Taherian Mobarakeh"
Background: Based on recent advances in tissue engineering and stem cell therapy in nervous system diseases treatments, this study aimed to investigate sciatic nerve regeneration using human endometrial stem cells (hEnSCs) encapsulated fibrin gel containing chitosan nanoparticle loaded by insulin (Ins-CPs). Stem cells and also Insulin (Ins), which is a strong signaling molecule in peripheral nerve regeneration, play an important role in neural tissue engineering.
Methods: The fibrin hydrogel scaffold containing insulin loaded chitosan particles was synthesized and characterized.
Hybrid fibrous mat containing cell interactive molecules offers the ability to deliver the cells and drugs in wound bed, which will help to achieve a high therapeutic treatment. In this study, a co-electrospun hybrid of polyvinyl alcohol (PVA), chitosan (Ch) and silk fibrous mat was developed and their wound healing potential by localizing bone marrow mesenchymal stem cells (MSCs)-derived keratinocytes on it was evaluated in vitro and in vivo. It was expected that fabricated hybrid construct could promote wound healing due to its structure, physical, biological specifications.
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- Human endometrial-derived stem cells (EnSC) are a promising resource for cell replacement therapy due to their abundance and ability to differentiate into multiple cell types, including neural cells.
- Flow cytometric analysis confirmed that EnSC express specific stem cell markers and can be induced into neural differentiation using signaling molecules like bFGF, PDGF, and EGF, which were analyzed for neuronal markers through RT-PCR and immunocytochemistry.
- The successful expression of neuronal proteins indicates that EnSC can effectively transform into neuronal cells, positioning them as a valuable option for treating neurodegenerative diseases.