The effect of curcumin on anthropometric indices, blood pressure, lipid profiles, fasting blood glucose, liver enzymes, fibrosis, and steatosis in non-alcoholic fatty livers.

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease. Curcumin is a natural polyphenol that may be effective against liver steatosis and steatohepatitis. The present study aimed to evaluate the effects of phytosomal curcumin on lipid profile, fasting blood sugar, anthropometric indices, liver enzymes, fibrosis, and steatosis in non-alcoholic fatty liver patients.

Recent Approaches to Enhance Osteogenesis of Dental Pulp Stem Cells on Electrospun Scaffolds.

Critical-sized bone defects are a challenging issue during bone regeneration. Bone tissue engineering is aimed to repair such defects using biomimicking scaffolds and stem cells. Electrospinning allows the fabrication of biocompatible, biodegradable, and strengthened scaffolds for bone regeneration.

Estrogen adsorption from an aqueous solution on the chitosan nanoparticles.

In this research, chitosan nanoparticles as an efficient and reusable adsorbent with adsorption capacity of 5.79 mg/g, surface area of 62 m/g and pH of 8.07 were applied to remove the ethinylestradiol (as a sample of estrogen) from an aqueous wastewater.

Cell homing strategy as a promising approach to the vitality of pulp-dentin complexes in endodontic therapy: focus on potential biomaterials.

Introduction: Over the last two decades, an increasing body of research suggests that well-designed biomaterials can attract resident stem cells to injured areas and control their behaviors and activities to encourage tissue regeneration. Fabricated biomaterials can enhance cell recruitment, multiplication, and transformation while also acting as a delivery system for targeted cells. These capabilities might play a role in their ability to promote tooth regeneration.

The salivary exosomal microRNA as a potential biomarker in patients with periodontitis and oral cancers.

Periodontitis and oral cancers are the most common oral diseases in the human population. The early diagnosis of oral diseases allows the efficient therapy of the patient. During oral diseases, resident cells in the affected tissue secrete exosomal microRNAs (miRNAs) into saliva.

Assessment of Inferior Alveolar Nerve Position at the Region of First and Second Mandibular Molars in Dentate and Edentulous Sites Using Cone Beam Computed Tomography: A Cross-Sectional Study.

Determining the position of the Inferior alveolar nerve (IAN) is an important factor prior to any surgical procedure in the mandible such as dental implant insertion and surgical tooth extraction. The aim of this study was to compare the position of IAN in partially edentulous patients in the lower first and second molars in both missing and dentate sides. A total of 200 CBCT scans were chosen randomly and examined.

Health impact assessment and evaluation of economic costs attributed to PM air pollution using BenMAP-CE.

Air pollution is considered the most prominent public health. Economically, air pollution imposes additional costs on governments. This study aimed to quantify health effects and associated economic values of reducing PM air pollution using BenMAP-CE in Qom in 2019.

Modeling and investigating the effect of parasol installation on solar radiant temperature reduction using COMSOL Multiphysics.

Occupational activities in open spaces can experience excessive heat exposure caused by sunlight and other artificial sources in these professional environments can be one of the current and future challenges of occupational safety and health due to increasing global warming. Use of lightweight portable parasols is the first available control measure to reduce the radiation emitted by the sun in outdoor workplaces, which has been used for a long time. Due to the lack of study and results on the effect of using parasols in scientific literature, this modeling study was conducted to investigate the effect of sunshade installation on radiant temperature reduction of the sun in outdoor work using COMSOL Multiphysics version 5.

The Effect of Curcumin Supplemsentation on Anthropometric Indices in Overweight and Obese Individuals: A Systematic Review of Randomized Controlled Trials.

Background: Curcumin is an active molecule present in turmeric and is the main therapeutic compound. There is growing evidence that curcumin could affect various anthropometric indices. We performed a systematic review to evaluate the efficacy of curcumin supplementation on anthropometric indices in obese and overweight individuals.

Awareness and Performance towards Proper Use of Disinfectants to Prevent COVID-19: The Case of Iran.

This study aimed to assess the awareness and performance of Qom citizens towards using disinfectants and compared its relationship with geographical distribution of COVID-19 outbreak in Qom, Iran. The study was conducted by a researcher-made questionnaire during April and May, 2020. COVID-19 incidence data for each district of city was obtained from health department of Qom province.

Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials.

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and refers to the accumulation of triglycerides in hepatocytes. Recent studies have showed that resveratrol (antioxidant of grape) can be effective in the treatment of NAFLD through its inhibitory effect on lipid accumulation.

Method: We systematically searched databases including: ISI web of science, Scopus, PubMed and Embase by using related keywords.

Singlet fission relevant energetics from optimally tuned range-separated hybrids.

As a promising idea to design high-efficiency organic photovoltaics, singlet fission (SF) mechanism, i.e., generating two triplet excitons out of a single photon absorption, has recently come into the spotlight.

Removal of Cefixime from Water Using Rice Starch by Response Surface Methodology.

Background: Remaining pharmaceutical compounds cause environmental pollution. Therefore, refining these compounds has become a major challenge. In this study, the function of eliminating Cefixime (CFX) using rice starch was evaluated under controlled conditions.

The effect of barberry (Berberis vulgaris L.) on glycemic indices: A systematic review and meta-analysis of randomized controlled trials.

Objective: We performed a meta-analysis to evaluate the efficacy of barberry (Berberis vulgaris L.) supplementation on glycemic indices in adults.

Methods: A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, and ISI Web of Science from inception up to January 2020, to identify randomized controlled trials (RCTs) investigating the effect of barberry supplementation on glycemic markers including fasting blood sugar (FBS) concentrations, insulin levels, homeostatic model assessment for insulin resistance (HOMA-IR), and glycosylated hemoglobin (HbA1c) percentage.

Murine Genetic Background Overcomes Gut Microbiota Changes to Explain Metabolic Response to High-Fat Diet.

Interactions of diet, gut microbiota, and host genetics play essential roles in the development of metabolic diseases. A/J and C57BL/6J (C57) are two mouse strains known to display different susceptibilities to metabolic disorders. In this context, we analyzed gut microbiota composition in A/J and C57 mice, and assessed its responses to high-fat diet (HFD) and antibiotic (AB) treatment.

Steatosis and gut microbiota dysbiosis induced by high-fat diet are reversed by 1-week chow diet administration.

Many studies have recently shown that diet and its impact on gut microbiota are closely related to obesity and metabolic diseases including nonalcoholic fatty liver disease. Gut microbiota may be an important intermediate link, causing gastrointestinal and metabolic diseases under the influence of changes in diet and genetic predisposition. The aim of this study was to assess the reversibility of liver phenotype in parallel with exploring the resilience of the mice gut microbiota by switching high-fat diet (HFD) to chow diet (CD).

Toward photophysical characteristics of triplet-triplet annihilation photon upconversion: a promising protocol from the perspective of optimally tuned range-separated hybrids.

The photon upconversion (UC) process assisted by the triplet-triplet annihilation (TTA) mechanism has recently come into the spotlight. Given the rich collection of efforts in this area, theoretical explorations regarding TTA-UC are relatively limited and have proven to be challenging for its control in devices. In this contribution, the photophysical properties crucial for TTA-UC, such as triplet excited state energies and triplet-triplet energy transfer gaps of the essential ingredients involved in the process, namely sensitizers, annihilators and their pairs, have theoretically been investigated using optimally tuned range-separated hybrid functionals (OT-RSHs) and their screened exchange counterparts, OT-SRSHs.

The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD).

NAFLD is currently the main cause of chronic liver disease in developed countries, and the number of NAFLD patients is growing worldwide. NAFLD often has similar symptoms to other metabolic disorders, including type 2 diabetes and obesity. Recently, the role of the gut microbiota in the pathophysiology of many diseases has been revealed.

Chromosomal aberrations, sister chromatid exchanges, and micronuclei in lymphocytes of oncology department personnel handling anti-neoplastic drugs.

Objective: Concern exists regarding the possible hazards to the personnel handling anti-neoplastic drugs. The purpose of the present study was to assess the genotoxicity induced by anti-neoplastic agents in oncology department personnel.

Materials And Methods: To do this, the frequency of chromosomal aberrations (CAs) induced in peripheral blood lymphocytes was assessed at G phase of the cell cycle using metaphase analysis, cytokinesis block-micronucleus (MN) assay and sister chromatid exchange (SCE) assay.

From information theory to quantitative description of steric effects.

Immense efforts have been made in the literature to apply the information theory descriptors for investigating the electronic structure theory of various systems. In the present study, the information theoretic quantities, such as Fisher information, Shannon entropy, Onicescu information energy, and Ghosh-Berkowitz-Parr entropy, have been used to present a quantitative description for one of the most widely used concepts in chemistry, namely the steric effects. Taking the experimental steric scales for the different compounds as benchmark sets, there are reasonable linear relationships between the experimental scales of the steric effects and theoretical values of steric energies calculated from information theory functionals.

Dendrosomal curcumin inhibits metastatic potential of human SW480 colon cancer cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 gene expression.

Colon cancer is one of the leading causes of cancer-associated death worldwide. The prognosis for advanced colorectal cancers remains dismal, mainly due to the propensity for metastatic progression. Accordingly, there is a need for effective anti-metastasis therapeutic agents.

Study of the effect of F17A mutation on characteristics of Bacillus thermocatenulatus lipase expressed in Pichia pastoris using in silico and experimental methods.

Bacillus thermocatenulatus lipase 2 (BTL2), a thermoalkalophilic lipase, is the best studied enzyme for its particular properties, which make it useful in different industries. Displacement of conserved phenylalanine 17 (Phe-17) residue in the active site of BTL2 has a critical role in oxyanion hole formation, which is important for enzyme activity. In this study, to facilitate oxyanion hole formation, Phe-17 was substituted with Alanine residue (F17A).

In silico and experimental characterization of chimeric Bacillus thermocatenulatus lipase with the complete conserved pentapeptide of Candida rugosa lipase.

Lipases are one of the highest value commercial enzymes as they have broad applications in detergent, food, pharmaceutical, and dairy industries. To provide chimeric Bacillus thermocatenulatus lipase (BTL2), the completely conserved pentapeptide (¹¹²Ala-His-Ser-Gln-Gly¹¹⁶) was replaced with similar sequences (²⁰⁷Gly-Glu-Ser-Ala-Gly²¹¹) of Candida rugosa lipase (CLR) at the nucleophilic elbow region. For this purpose, three mutations including A112G, H113E, and Q115A were inserted in the conserved pentapeptide sequence of btl2 gene.

Impact of fumonisin B1 on the production of inflammatory cytokines by gastric and colon cell lines.

Fumonisins, a family of mycotoxins, are mainly toxic and carcinogenic. The present study was carried out to evaluate fumonisin B1 (FB1) effects on the production of inflammatory cytokines by gastric and colon cell lines. The study was performed on two cell lines under in vitro condition, including gastric epithelial cell line (AGS) and human colon adenocarcinoma cell line (SW742).

Poly[aqua-(dimethyl sulfoxide)(μ(4)-pyridine-2,5-dicarboxyl-ato)calcium(II)].

In the polymeric title compound, [Ca(C(7)H(3)NO(4))(H(2)O)(C(2)H(6)OS)](n), the Ca(II) ion is coordinated in a distorted penta-gonal-bipyramidal CdNO(6) geometry. The crystal packing is stabilized by O-H⋯O hydrogen bonds and π-π stacking inter-actions between the aromatic rings of pyridine-2,5-dicarb-oxy-late with centroid-centroid distances of 3.6166 (13) Å.