Burden attributable to Iodine deficiency in Iran from 1990 to 2019: findings from Global Burden of Disease study.

Introduction: Iodine is necessary for the synthesis of thyroid hormones which rely on sufficient levels of iodine. Iodine deficiency (ID) gives rise to various diseases. This is the first study presenting the epidemiology of ID in the Iranian population from 1992 to 2019.

Enhancing clinical risk assessment in pediatric blunt abdominal trauma: A novel scoring system using ultrasound and laboratory data.

Background: Given the importance of diagnosing intra-abdominal injury (IAI) in children with blunt abdominal trauma (BAT) and preventing radiation exposure to children by avoiding CT scans, this study aimed to evaluate a scoring criterion based on ultrasound (US) findings and laboratory data in assessing the clinical risk of IAI in children with BAT.

Materials And Methods: In this retrospective study, baseline and clinical information of 180 children (under 18 years of age) with BAT including physical examination, hemodynamic parameters, and laboratory data, were extracted from medical records. US findings were considered abnormal if any report of mild free fluid or solid organ injury was noted.

Generalized Coupled Matrix Tensor Factorization Method Based on Normalized Mutual Information for Simultaneous EEG-fMRI Data Analysis.

The complementary properties of both modalities can be exploited through the fusion of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data. Thus, a joint analysis of both modalities can be used in brain studies to estimate brain activity's shared and unshared components. This study introduces a comprehensive approach for jointly analyzing EEG and fMRI data using the advanced coupled matrix tensor factorization (ACMTF) method.

Detection of epileptic seizures through EEG signals using entropy features and ensemble learning.

Introduction: Epilepsy is a disorder of the central nervous system that is often accompanied by recurrent seizures. World health organization (WHO) estimated that more than 50 million people worldwide suffer from epilepsy. Although electroencephalogram (EEG) signals contain vital physiological and pathological information of brain and they are a prominent medical tool for detecting epileptic seizures, visual interpretation of such tools is time-consuming.

Effects of Essential Oil in Preventing Seizure in Pentylenetetrazol-Kindled Mice.

Introduction: Epilepsy is a group of chronic neurological disorders characterized by seizures. The present study aimed to investigate the effects of essential oil in preventing epilepsy.

Methods: In this experimental study, 50 mice were randomly assigned to five groups of 10 each.

Neuroprotective effect of wild lowbush blueberry (Vaccinium angustifolium) on global cerebral ischemia/reperfusion injury in rats: Downregulation of iNOS/TNF-α and upregulation of miR-146a/miR-21 expression.

This study aims to investigate the neuroprotective effect of wild lowbush blueberry on CIRI in rats. Accordingly, CIRI and reperfusion were induced in rats for 60 min and 24 h, respectively. Then, the mechanisms of the neuroprotective effects of BBE were investigated in the injury through evaluating miR-146a, miR-21, and their targets in a CIRI rat model.

Physiological and biochemical traits in coriander affected by plant growth-promoting rhizobacteria under salt stress.

Salinity is a major environmental stress that limits crop production worldwide. It is well-understood that environmental adaptations, physiological and biochemical traits adjust salinity tolerance in plants, but imparting the knowledge gained towards crop improvement remain arduous. Utilizing the potentially of beneficial microorganisms present in the rhizosphere is an alternative strategy to improve crop production under optimal or stress conditions.

Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat.

Background: Previous studies have shown that seizures can cause cognitive disorders. On the other hand, the Curcuma zedoaria (CZ) has beneficial effects on the nervous system. However, there is little information on the possible effects of the CZ extract on seizures.

Hydroalcoholic Extract of Anchusa Italica Protects Global Cerebral Ischemia-Reperfusion Injury Via a Nitrergic Mechanism.

Introduction: In stroke models, Inducible Nitric Oxide Synthase (iNOS) expression initiates cellular toxicity due to excessive Nitric Oxide (NO) generation. Anchusa italica is a medicinal herb with anti-inflammatory, antioxidant and neuroprotective properties. This study evaluated the antioxidant activity and NOS mRNA expression of the Hydroalcoholic Extract Of Anchusa Italica (HEAI) in an experimental stroke model in rats.

Therapeutic Effects of Oleuropein in Improving Seizure, Oxidative Stress and Cognitive Disorder in Pentylenetetrazole Kindling Model of Epilepsy in Mice.

Prolonged epileptic seizures are the cause of neuronal death and brain damage. Lesions in different regions of the brain can lead to memory loss and cognitive disorders. It is therefore essential to seek out new neuroprotective drugs.

Phytotherapy as a Complementary Medicine for Multiple Sclerosis.

Multiple sclerosis (MS) is the most common cause of neurologic disability in adults worldwide. Two main issues have caused MS patients to face several problems. One issue is that the definite cause of MS has not yet been determined and the other issue is the lack of a definite treatment for this disease.

The effect of pretreatment with hydroalcoholic extract of rhizome on seizure severity and memory impairment in pentylenetetrazol-induced kindling model of seizure in rat.

The aim of present study is to investigate pretreatment with hydroalcoholic extract of rhizome on the severity of epilepsy and memory impairment in rat. In this experimental study, rats were randomly assigned to seven groups. Control group and negative control group were intraperitoneally injected with normal saline and PTZ, respectively, for 10 days.

Phytotherapy in treatment of Parkinson's disease: a review.

: Parkinson's disease (PD) is a neurodegenerative disorder due to gradual loss of dopaminergic nerves in the substantia nigra (SN) in the midbrain. PD leads to certain motor disorders including resting tremor, muscle stiffness and slow movement. Medicinal plants have shown positive pharmacological effects in treating different models of PD.

Effect of hydroalcoholic Echium amoenum extract on scopolamine-induced learning and memory impairment in rats.

Context: Scopolamine, a muscarinic receptor antagonist, causes memory loss that resembles Alzheimer's disease (AD). Echium amoenum L. (Boraginaceae) is a famous medicinal plant of Iran that is traditionally used as a sedative and mood enhancer.

Effect of gallic acid on chronic restraint stress-induced anxiety and memory loss in male BALB/c mice.

Objectives: Long-term exposure to stress leads to memory deficits and certain mood disorders such as depression and anxiety. We aimed to study the effect of gallic acid (GA) on chronic restraint stress (CRS) induced anxiety and memory deficits in male BALB/c mice.

Materials And Methods: Ninety male BALB/c mice were assigned to nine groups including caged control (CC): food-water deprived (FWD), under chronic restraint stress (CRS), CRS+ gallic acid (5, 10, and 20 mg/kg), and gallic acid (5, 10, and 20 mg/kg).

Effect of Rheum Ribes Hydro-Alcoholic Extract on Memory Impairments in Rat Model of Alzheimer's Disease.

Some animal models have been used to study Alzheimer's disease (AD). AD is an irreversible progressive neurodegenerative disease and the most common cause of dementia. Animal studies have shown that there is a relation between decrease in cholinergic functions in the nucleus basalis of Meynert (NBM) and loss of learning capability and memory.

Effect of Dietary Ethanolic Extract of Lavandula officinalis on Serum Lipids Profile in Rats.

Antioxidants are effective in prevention and treatment of cardiovascular diseases. Lavandula officinalis possesses antioxidant activity, therefore, in this study; the effects of Lavandula officinalis extract were investigated on serum lipids levels of rats. Experimental mature male Wistar rats were treated with 100, 200 or 400 mg/Kg/day of lavender ethanolic extract or distilled water for 25 days via gastric gavage (n=8 each group).

Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats.

Alzheimer's disease (AD) is a progressive neurological disorder that mostly affects the elderly population. Learning and memory impairment as the most characteristic manifestation of dementia could be induced chemically by scopolamine, a cholinergic antagonist. Cholinergic neurotransmission mediated brain oxidative stress.

Neuroprotective effect of pretreatment with Lavandula officinalis ethanolic extract on blood-brain barrier permeability in a rat stroke model.

Objective: To evaluate the protective effect of Lavandula officinalis (L. officinalis) extract against blood-brain barrier (BBB) permeability and its possible mechanisms in an experimental model of stroke.

Methods: Focal cerebral ischemia was induced by the transient occlusion of the middle cerebral artery for 1 h in rats.

Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus Basalis of Meynert in rat.

Alzheimer's disease (AD) is a common neurodegenerative condition that affects the elderly population. Its primary symptom is memory loss. The memory dysfunction in AD has been associated with cortical cholinergic deficiency and loss of cholinergic neurons of the nucleus basalis of Meynert (NBM).

Antispasmodic effects of yarrow (Achillea millefolium L.) extract in the isolated ileum of rat.

Achillea millefolium L. is cultivated in Iran and widely used in traditional medicine for gastrointestinal disorders. The aim of this study was to determine the effect of hydroalcoholic extract of A.

Neuroprotection of dietary virgin olive oil on brain lipidomics during stroke.

Recent studies suggest that dietary virgin olive oil reduces hypoxia-reoxygenation injury in rat brain. This study investigated the effect of pretreatment with different doses of dietary virgin olive oil on brain lipidomics during stroke. In this experimental trial, 60 male Wistar rats were studied in 5 groups of 12 each.

The neuroprotection effect of pretreatment with olive leaf extract on brain lipidomics in rat stroke model.

Background: Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. We have attempted to determine the effect of dietary olive leaf extract (OLE) on brain lipidomics in rat stroke model.

Methods: Five groups, each consisting of 12 male Wistar rats, were studied.