Publications by authors named "Zahra Pakrouh Jahromi"
Article Synopsis
- - A novel compound called (2,4-Dimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1-benzo[]imidazole-6-carboxamide (5o) was created and tested for its effectiveness in killing human cancer cells (A549 and SW480) compared to normal cells (MRC-5) using the MTT assay.
- - Compound 5o demonstrated exceptional cytotoxicity with very low effective concentrations (IC values of 0.15 μM for A549 and 3.68 μM for SW480), significantly outperforming standard cancer treatments like cisplatin, etoposide, and doxorubicin.
- - The study
Article Synopsis
- * The most potent compounds showed IC values below 40 μM, indicating strong anti-proliferative activity, while one compound demonstrated significant free radical scavenging potential against DPPH radicals.
- * Additional studies, including molecular docking and dynamics simulations, confirmed these compounds interact well with cyclin-dependent kinase-2 (CDK2), and one compound, in particular, shows promise as a lead candidate for cancer treatment based on pharmacokinetic properties.
