Publications by authors named "Zahra Laouby"
Significance: The development of imaging systems that are cost-efficient and modular is essential for modern neuroscience research.
Aim: In the current study, we designed, developed, and characterized a low-cost reversible tandem lens mesoscope for brain imaging in rodents.
Approach: Using readily available components, we assembled a robust imaging system that is highly efficient and cost-effective.
Article Synopsis
- Researchers have identified long-chain acylcarnitines (LC ACs) in a rat spinal cord injury model using 3D mass spectrometry imaging for the first time.
- Specific types of acylcarnitines were observed at the injury site as early as 3 days post-injury and remained detectable for up to 10 days, showing distinct patterns around the lesion.
- The localization of these lipids along with the presence of microglia/macrophages suggests they may play an important role in the inflammatory response and progression of spinal cord injuries.
Article Synopsis
- The study explores the use of RhoA inhibitors (RhoAi) for treating spinal cord injuries (SCI) by analyzing their effects on dorsal root ganglia (DRG) cells in various culture conditions.
- Researchers created a neuroproteomic-systems biology platform to track molecular changes over time following RhoAi treatment, revealing alterations in transcription factors and growth cone-related factors that aid in nerve regeneration.
- In a rat model, RhoAi delivered with FK506 showed early recovery in movement and increased synaptic connections, highlighting the need for ongoing treatment to support axon regeneration and improve long-term functional outcomes.