Publications by authors named "Zahra Khuhro"
Perinatal Inflammation Results in Sex-Dependent Cardiac Dysfunction.
J Cardiovasc Dev Dis
November 2024
Article Synopsis
- Higher rates of adult heart failure are linked to individuals born preterm or with poor fetal growth, often influenced by adverse maternal conditions and the need for oxygen therapy post-birth.
- Research using a mouse model evaluated the impact of maternal inflammation and oxygen exposure on cardiac health, revealing sex differences in the progression of heart issues by 10 months.
- Results showed that early changes in heart-related proteins can indicate potential heart problems in adulthood, especially more severe in males, suggesting these patterns might also apply to humans, particularly in infants with growth restrictions.
Effects of DNA methylase inhibitors in a murine model of severe BPD.
Respir Physiol Neurobiol
July 2023
DNA methylation is necessary for developmental gene regulation, but adverse environments result in aberrant methylation and gene silencing. The current pilot study tested the hypothesis that treatment with DNA methylation inhibitors (decitabine; RG108) would improve alveolarization in a newborn murine model of severe bronchopulmonary dysplasia. Newborn mice exposed to maternal inflammation (LPS) and neonatal hyperoxia (85% O) were treated with decitabine (p3, 0.
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