Structure-bioactivity relationship study on anticancer Pd and Pt complexes with aliphatic glycine derivative ligands.

To investigate the structure and bioactivity relationship, six Pd(II)/Pt(II) complexes with N-isobutylglycine (L) and cyclohexylglycine (L) as N^O amino acid bidentate ligands, 1,10'-phenanthroline (phen) and 2,2'-bipyridine (bipy) as N^N donor ligands, and [Pd(L)(bipy)]NO (1), [Pd(L)(bipy)]NO (2), [Pd(L)(phen)]NO (3), [Pd(L)(phen)]NO·2HO (4), [Pt(L)(phen)]NO (5), along with [Pt(L)(phen)]NO (6) were prepared and then characterized. The geometry of each compound was validated by doing a DFT calculation. Furthermore, tests were conducted on the complexes' water solubilities and lipophilicity.

Biological Activity of Two Anticancer Pt Complexes with a Cyclohexylglycine Ligand against a Colon Cancer Cell Line: Theoretical and Experimental Study.

Because of their extraordinary ability to disrupt the natural structure of nucleic acids, metal complexes could be used in cancer therapy. In this study, cyclohexylglycine () as a ligand and two new Pt complexes, [Pt(NH)(L)]NO () and [Pt(bipy)(L)]NO (), were synthesized and characterized by elemental analysis, LC-MS, UV-vis spectrometry, FT-IR, H NMR spectroscopy, C NMR spectroscopy, Pt NMR spectroscopy, HPLC analysis, and single-crystal X-ray diffraction. Complex crystallized in the orthorhombic space group, and density functional theory (DFT) was used to describe its structural parameters were described in detail.

Property evaluation of two anticancer candidate platinum complexes with N-isobutyl glycine ligand against human colon cancer.

Small molecules have potential usage in cancer therapy due to their remarkable potency of disarranging the natural structure of nucleic acids. In this study, two complexes [Pt(NH)(IBgly)]NO (1) and [Pt(bipy)(IBgly)]NO (2) based on Pt(II), N-isobutylglycine (IBgly), 2,2'-bipyridine, and ammonia were prepared and characterized by spectroscopic methods. Pharmacokinetic ADME data, absorption, distribution, metabolism, excretion, and bioavailability radar showed two complexes can be introduced for Pt-based anti-cancer drugs.

Effects of -oxidation on the molecular and crystal structures and properties of isocinchomeronic acid, its metal complexes and their supramolecular architectures: experimental, CSD survey, solution and theoretical approaches.

Nine coordination complexes and polymer (M/L/X) based on Co, Ni, Zn, Cu (M), pyridine--oxide-2,5-dicarboxylic acid (Hpydco) (L) and either isonicotinamide (Ina), piperazine (pipz), 2,2'-bipyridine (bipy) and 1,10-phenanthroline (phen) (X) were synthesized and characterized by elemental analyses, infrared spectroscopy and single crystal X-ray diffraction. The resulting empirical formulae of the prepared complexes are [Co(HO)][Co(pydco)(HO)]·2HO (1), [M(pydco)(HO)] [M = Co (2), Ni (3), Zn (4)], [Co(pydco)(bipy)(HO)]·4HO (5), [Co(pydco)(phen)(HO)]·5.135(HO)·0.