p75(NTR) is an important receptor that connects the immune and nervous systems, playing a key role in allergic asthma and Schwann cell responses after nerve injury.
Researchers created specific siRNA to test if it could effectively downregulate p75(NTR) and RhoA gene expression in rat Schwann cells.
The results showed that p75(NTR) expression decreased by 73% and RhoA by 89%, leading to significantly reduced apoptosis (cell death) in Schwann cells treated with the siRNA compared to the control group.