Collagen-coated superparamagnetic iron oxide nanoparticles as a sustainable catalyst for spirooxindole synthesis.

In this work, a novel magnetic organic-inorganic hybrid catalyst was fabricated by encapsulating magnetite@silica (FeO@SiO) nanoparticles with Isinglass protein collagen (IGPC) using epichlorohydrin (ECH) as a crosslinking agent. Characterization studies of the prepared particles were accomplished by various analytical techniques specifically, Fourier transform infrared (FTIR) analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), energy-dispersive X-ray spectroscopy (EDS), X-ray powder diffraction (XRD), thermogravimetric analysis (TGA), and Brunauer-Emmett-Teller (BET) analysis. The XRD results showed a crystalline and amorphous phase which contribute to magnetite and isinglass respectively.

Peanut shell as a green biomolecule support for anchoring CuO: a biocatalyst for green synthesis of 1,2,3-triazoles under ultrasonic irradiation.

CuO supported on peanut shell (CuO@PS) was prepared by the reaction of copper acetate and peanut shell powder as a naturally available biopolymer support. The prepared catalyst was used as an efficient and reusable heterogeneous catalyst in the click reaction of benzyl halide or phenacyl bromides, acetylenes and sodium azide for the synthesis of potentially biologically active 1,2,3-triazoles under ultrasonic irradiation in EtOH-HO as green solvent.

Magnetic core-shell Carrageenan moss/FeO: a polysaccharide-based metallic nanoparticles for synthesis of pyrimidinone derivatives via Biginelli reaction.

Magnetically recoverable polysaccharide-based metallic nanoparticles Carrageenan moss/FeO (FeO@CM) was tested for the synthesis of Pyrimidinone derivatives via Biginelli reaction under reflux conditions in Water. Interestingly, FeO@CM prepared from unmodified Irish moss showed remarkable catalytic activity and recyclability. Low catalyst loading, simple reaction procedure, and using a green catalyst from a natural source are the important merits of this protocol.

Ultrasonic-Assisted Preparation, Characterization, and Use of Novel Biocompatible Core/Shell FeO@GA@Isinglass in the Synthesis of 1,4-Dihydropyridine and 4-Pyran Derivatives.

This work focussed on the synthesis of a new catalytic material isinglass (IG)-based FeO@GA@IG core/shell magnetic nanoparticles and the investigation of its catalytic activity in two important multicomponent reactions. FeO nanoparticles were prepared using a simple coprecipitation method and then coated with IG consisting predominantly of the protein collagen in the presence of glutaraldehyde as a cross-linking agent. The obtained hybrid material has been characterized by Fourier transform infrared analysis, scanning electron microscopy, transmission electron microscopy (TEM), vibrating sample magnetometry, energy-dispersive X-ray, X-ray diffraction (XRD), and Brunauer-Emmett-Teller analyses.

An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst.

A simple solvent-free protocol for the preparation of flunixin, a potent non-narcotic, non-steroidal anti-inflammatory drugs is reported using boric acid as catalyst. Its salt, flunixin meglumine are then prepared under reflux in EtOH. This sustainable method are then extended for the synthesis of a series of 2-(arylamino) nicotinic acid derivatives.

Synthesis, Molecular Docking, Molecular Dynamics Studies, and Biological Evaluation of 4H-Chromone-1,2,3,4-tetrahydropyrimidine-5-carboxylate Derivatives as Potential Antileukemic Agents.

A series of 4H-chromone-1,2,3,4-tetrahydropyrimidine-5-carboxylates derivatives were synthesized via a three component one-pot condensation of chromone-3-carbaldehyde, alkyl acetoacetate, and urea or thiourea, using MCM-41-SOH as efficient nanocatalysts and evaluated for their anticancer activity using a combined in silico docking and molecular dynamics protocol to estimate the binding affinity of the title compounds with the Bcr-Abl oncogene. Two programs, AutoDock 4 and AutoDock Vina software were applied to dock the target protein with synthesized compounds and ATP. AutoDock runs resulted in binding energy scores from -7.