Infections due to Acinetobacter baumannii (A. baumannii) are rapidly increasing worldwide and consequently therapeutic options for treatment are limited. The emergence of multi drug resistant (MDR) strains has rendered available antibiotics ineffective, necessitating the urgent discovery of new drugs and drug targets.
View Article and Find Full Text PDFThe spread of infection is directly determined by the ability of a pathogen to invade and infect host tissues. The process involves adherence due to host-pathogen interactions and traversal into deeper tissues. Mycobacterium tuberculosis (Mtb) primarily infects the lung but is unique in its ability to infect almost any other organ of the human host including immune privileged sites such as the central nervous system (CNS).
View Article and Find Full Text PDFJ Antimicrob Chemother
April 2019
Background: The emergence of drug-resistant bacteria is a major hurdle for effective treatment of infections caused by Mycobacterium tuberculosis and ESKAPE pathogens. In comparison with conventional drug discovery, drug repurposing offers an effective yet rapid approach to identifying novel antibiotics.
Methods: Ethyl bromopyruvate was evaluated for its ability to inhibit M.
Front Cell Infect Microbiol
February 2018
Iron is crucial for the survival of living cells, particularly the human pathogen which uses multiple strategies to acquire and store iron. synthesizes high affinity iron chelators (siderophores), these extract iron from host iron carrier proteins such as transferrin (Tf) and lactoferrin (Lf). Recent studies have revealed that may also relocate several housekeeping proteins to the cell surface for capture and internalization of host iron carrier protein transferrin.
View Article and Find Full Text PDFGlyceraldehyde-3-phosphate dehydrogenase [GAPDH, NAD + oxidoreductase (phosphorylating) 1.2.1.
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