[The first results of a combined all-Russian study on clinical genetics of multiple sclerosis].

Multiple sclerosis is a classic multifactorial disease in which etiology interaction of external factors and structural features of a large number of genes plays an important role. Identifying risk factors for multiple sclerosis and creating an integrated model of pathogenesis are urgent tasks of neurology. Revealing true risk factors is possible only in studies with sufficient statistical power, so with a large amount of samples.

[Participation of the lipid peroxidation processes in the adaptation mechanism of Muridae like rodents to the radioactive contamination of the Chernobyl NPP zone].

Results of the comparative analysis of the complex investigation of rodent population state caught at areas with different levels of contamination in the accident zone of the Chernobyl NPP during 1986-1993 and 2007, at areas with a practically normal radiation background in the neighborhood of the Kiev City in 1993 and at areas with the normal and increased radiation background in Ukhta region of Komi Republic in 1993-2008 are presented. It is shown that the absence of the linear dependence in changes of the lipid peroxidation (LPO) regulatory system parameters in rodent tissues on the dose of the external gamma-radiation at areas of their trap persists for a long time. Different ability to normalization of the studied indices and nonlinearity of their dose dependences allow us to suggest that changes of the scale and direction of interrelations between the reciprocal parameters of the LPO regulatory system in norm in tissues of rodents which were caught in the accident zone and at areas with an increased radiation background should be the information signal determining selection of the strategy of adaptation to the chronic radiation factor action.

[Action of the radioactive environment contamination on the age changes of the lipid peroxidation state in the rodent tissues].

Influence of the environment radioactive contamination on the age changes of the lipid peroxidation state in the Microtus oeconomus tissues (rodents caught in the Komi Republic areas and in the Chernobyl accident zone) was studied. The data show that action extent depends on the external y-radiation level in the trapping areas, the animal sex and the supply of the tissue lipids by antioxidants.

[Correlation of phospholipid composition and physicochemical characteristics of lipids in tissues of the root vole Microtus oeconomus of different ages].

There was performed a comparative analysis of phospholipids and of lipid physicochemical characteristics in spleen, blood erythrocytes, and liver of the root voles caught in the natural environmental habitation at different phases of the population cycle, as well as of the animals born and raised throughout the entire life in vivarium, depending on the animals' sex and age. The age-related changes in the phospholipid composition have been established to correlate with lipid physicochemical characteristics, while the scale and direction of the changes depend on the tissue functional role, the initial level of the antioxidative activity (AOA) of its lipids, and sex of the animals. In the process of the organism aging, parameters of the system of regulation of lipid peroxidation change not unidirectionally; in group of animals of the same age, individuals with different biochemical characteristics can be present.

[Dependence of response reaction of root voles to low-intensity irradiation on the initial state of the tissue antioxidant system].

There has been studied the response of antioxidant (AO) reaction of the tissue system of the root voles Microtus oeconomus Pall. whose parents belonged to the populations long inhabiting the Republic Komi regions with different degrees of radioactive contamination on an additional radiation action at low doses. Differences have been revealed in the phospholipid content, activities of AO defense, intensities of processes of lipid peroxidation (LPO) in tissues of the vole offspring caught in the control and contaminated regions.

[The age characteristics of lipid peroxidation in tissues from wild rodents].

The comparative analysis of the phospholipid composition and the physics-chemical characteristics of the spleen, blood erythrocytes and liver lipids of wild rodents of different age (Microtus oeconomus Pall.) was carried out. The interrelation between the age changes of the phospholipid composition in spleen and/or the antiperoxide activity and the content of peroxides in lipids was shown.

[The antiradiation properties of the ecdysteroid-containing compounds].

The antiradiation properties of the ecdysteroid-containing preparations ("serpisten" and inokosterone) are studied under their application before or after the 22.6 cGy chronic low intensity gamma-irradiation of mice. It is shown that the antiradiation of these compounds depend on the dose of preparations and time of the application before or after irradiation of mice.

[Influence of the chronic gamma-irradiation at the low doses during the near ontogenesis periods on the oxidative processes in rodent organs].

It is shown that the effect of the low intensity gamma-irradiation at the dose of 5.5 cGy during the 4 months including the antenatal period causes the most substantial changes of the peroxide content in the liver and in brain lipids and of TBA-reactive substances amount in organs and blood plasma of tundra vole F2 which are reproduced from parents during long-term inhabiting on the Ra-contaminated area in the Komi Republic. The consequences of the chronic gamma-irradiation at the doses of 4 cGy (the dose rate is 5 mR/h) and 31 cGy (the dose rate is 40 mR/h) are studied by the morphophysiological and by biochemical parameters in organs of mice CBA (males) within 3 months after exposure.

[The regulation of the oxidative processes in the tissues of Muridae like rodents caught in the Chernobyl accident zone].

The results of the investigations of the radioactive contamination consequences on the lipid peroxidation (LPO) processes in organs and tissues of wild rodents which were caught in the Chernobyl NPP accident 30-km zone during 1986-1993 are generalized. The behaviors of the technogenic contamination effect on dynamic of changes of the LPO physico-chemical regulatory system parameters and the generalized parameters of the phospholipid composition in organs of the different radioresistance wild rodents are revealed in dependence on the radioactive contamination level and the duration of the radiation factor exposure. Different sensitivity of the LPO regulatory system parameters in wild rodent tissues to the radioactive contamination of their environment and the unequal ability to normalization of the antioxidant status and the energy exchange in tissues result in the change of the scale and character of interrelations between the reciprocal parameters in norm and have an influence on the development of qualitatively new subpopulations of wild rodents due to the transition of the cell regulatory system to the another level of the function.

[The parameters of antioxidant status of tissues in the offspring of tundra vole (Microtus oeconomus Pall.) inhabiting areas with increased natural radioactivity].

The parameters of the lipid peroxidation regulatory system (the antioxidative and antiperoxidant activities, the peroxide content, the lipid peroxidation intensity) in the tissues and the activities of the antioxidative defence enzymes (the peroxidase activity in blood, the superoxide dismutase activity in the blood erythrocytes) are studied in progeny of tundra vole which are reproduced from parent inhabiting areas with different radioecological environment during a long time. The progeny had the preservation of the changed antioxidant status. The scale of the changing of the investigating parameters depend on the state of radionucleoids contamination of areas where tundra voles are caught, sex of rodents, the content of antioxidants in lipids of tissues of parents.

[Monitoring of tundra vole (Microtus oeconomus Pall.) population inhabiting areas with increased radiation background].

The data of complex examinations of morphophysiological state of Tundra vole (Microtus oeconomus Pall.), the lipid peroxidation (LPO) processes and the energy exchange in their organs, the cytogenetic analysis of marrow cells and the process of multiplication in populations inhabiting areas with increased natural radiation background more 50 years are generalized. The data obtained support the existence of qualitative differences of Tundra vole subpopulations inhabiting control and radioactive nuclide contaminating areas.

[The phospholipid composition of the liver in root voles living under different radioecological conditions].

The effect of the increased natural radiation background (within some areas in Komi Republic) and man-caused radioactive contamination in the Chernobyl NPP accident zone on the composition of liver phospholipids in Microtus oeconomus inhabiting these areas was studied. The significant changes in the liver lipid composition in rodents inhabiting both the Chernobyl accident zone and the areas with the increased natural radiation background were found. The maximal changes in the liver phospholipid composition were revealed during the first year after the accident.

[Influence of radioactive pollution on the character of the distribution of wild mouselike rodents according to the measure of lipid antioxidant activity in their organs].

The estimation of the degree of the radioactive contamination effect on the antioxidative status in tissues of rodents from natural populations is done by means of biometric methods. It is shown, that the character of distribution and variability of the lipids antioxidant activity (AOA) differs significantly depending of species and age of animals, the degree of contamination on areas where wild rodents were caught and time during which the radioactive factor affected. The change in character of the animals distribution in AOA of the brain lipids for the more radioresistant Clethrionomys glareolus Schreb, occurs the later than for the more radiosensitive Apodemus agrarius and especially for Microtus oeconomus Pall.

[The effect of infrared laser radiation of different frequencies on the healing of skin wounds].

In experiments on white rat males it was established that infrared laser radiation (frequency 500 Hz) was more potent in stimulating repair of skin wounds than 3000 Hz radiation. This manifested in enhanced proliferative activity of fibroblasts and epithelial cells, decreased areas of the wound.

[Biochemical changes in the brain of the root vole (Microtus oeconomus) from a 30-kilometer zone around the Chernobyl Atomic Electric Power Station].

Deviations in lipid peroxidation parameters and in activity of dehydration enzymes in the brain of the tundra voles inhabiting areas with higher level of technogenic contamination (the 30-km zone of the Chernobyl NPP and the Republic of Komi) have been analyzed. During the first years after the disaster a decrease in the lipid antioxidative status of the brain and dehydrogenase activity, changes in the lipid composition of voles trapped in the disaster zone in comparison with control ones were more significant. Relative stabilization of the phospholipid composition with low antioxidizing activity of lipids and slight activity of succinate and piruvate dehydrogenases has been observed in a distant period of analysis.

[The action of sulfate mineral water in experimental whole-body irradiation].

The authors' experiments have shown that a course intake of sulfate mineral water after total radiation (1 and 5 Gy) can prevent and minimize dystrophic and necrobiotic changes in the liver, stimulate intracellular regeneration, reduce pathological mitoses in the small intestine. The response depended on radiation dose and time of crenotherapy start after radiation. Sulfate mineral water is also a weak radioprotector.

[Postradiation recovery processes in the body with the internal use of iodine-containing waters].

It is shown that both natural and dissolved iodine-bromine water given in courses to animals preexposed to 1 Gy gamma radiation promotes recovery of the damaged processes in the body. The therapeutic action of natural mineral water proved more beneficial because such water contains more iodine and minerals.

[The structural-functional disorders in the liver of wild rodents from areas of the accident at the Chernobyl Atomic Electric Power Station].

A study was made of the morphological status of hepatocytes, the antioxidant activity of lipids and composition of phospholipids, and dehydrogenase activity in the liver of field mice taken from seven regions of the Chernobyl A.P.S.

[The effect of the internal use of radon water on the recovery processes in experimental stomach ulcer].

Radon experiments have established that oral courses of water containing either radon or its decay products in optimal doses can promote healing of gastric ulcer. The speed of such healing is believed to depend on the dose absorbed by a thin layer (about 100 microM) of gastric mucosa.

[The effect of rhythmic gymnastics on the physiologic indices of those who practice it].

A variety of the Chinese gymnastics was studied in relation to performance status of essentially healthy subjects. Thirty-three office workers exercised twice a week during 5 months. A positive trend was observed in nervous and emotional status, cardiovascular adaptation to muscular loads, external respiration, fatigue after 5 working days.