Publications by authors named "Zager E"

Article Synopsis
  • A 61-year-old man experienced a decade of worsening numbness and weakness in his right leg, prompting a thorough medical evaluation.
  • His examination revealed significant muscle weakness, loss of sensations, and reduced reflexes in the affected limb, leading to a diagnosis of chronic lumbosacral radiculoplexus neuropathy through electrodiagnostic tests.
  • A nerve biopsy provided a definitive diagnosis of a rare disease, highlighting the importance of a structured approach to identifying potential causes of lumbosacral plexopathies and discussing treatment options.
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Objective: Common peroneal (fibular) neuropathy is the most common mononeuropathy of the lower extremity. Despite this, there are surprisingly few studies on the topic, and a knowledge gap remains in the literature. As one attempts to address this knowledge gap, a core outcome set (COS) is needed to guide the planning phases of future studies to allow synthesis and comparability of these studies.

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Objective: When considering traumatic brachial plexus and upper extremity nerve injuries, iatrogenic nerve injuries, and nontraumatic nerve injuries, brachial plexus and upper extremity nerve injuries are commonly encountered in clinical practice. Despite this, data synthesis and comparison of available studies are difficult. This is at least in part due to the lack of standardization in reporting and a lack of a core outcome set (COS).

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Background: Occipital neuralgia (ON) is a debilitating headache disorder. Due to the rarity of this disorder and lack of high-level evidence, a clear framework for choosing the optimal surgical approach for medically refractory ON incorporating shared decision making with patients does not exist.

Methods: A literature review of studies reporting pain outcomes of patients who underwent surgical treatment for ON was performed, as well as a retrospective chart review of patients who underwent surgery for ON within our institution.

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Cervical spinal cord injury (SCI) causes devastating loss of upper limb function and independence. Restoration of upper limb function can have a profound impact on independence and quality of life. In low-cervical SCI (level C5-C8), upper limb function can be restored via reinnervation strategies such as nerve transfer surgery.

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Article Synopsis
  • Ulnar neuropathy at the elbow (UNE) affects a notable portion of the population, but there is no clear agreement on treatment methods due to inconsistent outcome reporting in studies.
  • This study aimed to create a Core Outcome Set for UNE (COS-UNE) using the modified Delphi method, involving stages like literature review and consensus surveys.
  • The final COS-UNE includes 22 key outcomes spanning various domains, establishes guidelines for reporting, and stresses the importance of consistent data collection in future research on UNE.
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Background: Historically, the transfemoral approach (TFA) has been the most common access site for cerebral intraoperative angiography (IOA). However, in line with trends in cardiac interventional vascular access preferences, the transradial approach (TRA) and transulnar approach (TUA) have been gaining popularity owing to favorable safety and patient satisfaction outcomes.

Objective: To compare the efficacy and safety of TRA/TUA and TFA for cerebral and spinal IOA at an institutional level over a 6-year period.

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Lymphomatoid granulomatosis is an Epstein-Barr virus-associated lymphoproliferative B-cell neoplasm that typically involves multiple organ systems. This disease is exceedingly rare when confined to the central nervous system (CNS), usually presenting as a mass lesion or diffuse disease, with no existing standard of care. We present the case of a 67-year-old patient who had a unique and insidious course of isolated CNS lymphomatoid granulomatosis.

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Background: Transradial approach for neuroangiography is becoming increasingly popular because of the advantages demonstrated by interventional cardiology. Many advantages of radial access could be applied to intraoperative angiography.

Objective: To report our institutional experience with transradial and transulnar intraoperative angiography, and evaluate its safety and feasibility.

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Background: Brachial plexus region tumors are rare. In this study, we reviewed our experience with resection of tumors involving or adjacent to the brachial plexus to identify patterns in presentation and outcome.

Methods: We report a retrospective case series of brachial plexus tumors operated on by a single surgeon at a single institution over 15 years.

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Objective: High cervical spinal cord injury (SCI) results in complete loss of upper-limb function, resulting in debilitating tetraplegia and permanent disability. Spontaneous motor recovery occurs to varying degrees in some patients, particularly in the 1st year postinjury. However, the impact of this upper-limb motor recovery on long-term functional outcomes remains unknown.

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Postoperative C5-6 palsies can occur in 5%-10% of cases after cervical spine surgery. In this video, the authors demonstrate operative techniques for nerve transfer to restore function for postoperative C5-6 palsy. The patient underwent C3-6 laminectomy and posterior fusion for cervical spondylotic myelopathy and developed weakness postoperatively in the C5-6 distribution bilaterally.

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Acellularized nerve allografts (ANAs) have been developed as substitutes for nerve autograft to promote nerve regeneration after surgical repair. In this video, the authors demonstrate operative techniques for using ANAs to repair potentially functional nerve fascicles during tumor resection. A 67-year-old female with schwannomatosis requested resection of a painful enlarging mass of the left ulnar nerve proximal to the elbow.

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Importance: Cervical spinal cord injury (SCI) causes devastating loss of upper extremity function and independence. Nerve transfers are a promising approach to reanimate upper limbs; however, there remains a paucity of high-quality evidence supporting a clinical benefit for patients with tetraplegia.

Objective: To evaluate the clinical utility of nerve transfers for reanimation of upper limb function in tetraplegia.

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Article Synopsis
  • Major peripheral nerve injury (PNI) presents difficulties in functional restoration due to slow axon growth and degeneration of the regenerative pathway without axons.
  • Researchers are creating tissue-engineered nerve grafts (TENGs) using porcine neurons and stretching techniques to provide living axons that help guide the regeneration of host axons and maintain nerve pathways.
  • TENGs have shown success in accelerating axon regeneration across both short (1 cm) and long (5 cm) nerve defects in pigs, achieving recovery comparable to traditional autograft methods, and showing promise for treating currently unrepairable PNIs.
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Article Synopsis
  • A 29-year-old man suffered a rare spinal cord injury, specifically Brown-Sequard syndrome, after attempting to manually manipulate his own cervical spine.
  • Imaging revealed significant disc herniations causing severe compression of the spinal cord, leading to an urgent surgical decompression.
  • The case emphasizes the importance of quick surgical treatment and rehabilitation, and cautions against the risks of self-cervical manipulation.
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Objective: The aim of this study was to examine the role of intraoperative neuromonitoring (IONM) during resection of benign peripheral nerve sheath tumors in achieving gross-total resection (GTR) and in reducing postoperative neurological complications.

Methods: Data from consecutive adult patients who underwent resection of a benign peripheral nerve sheath tumor at 7 participating institutions were combined. Propensity score matching was used to balance covariates.

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Background: In an attempt to improve care while decreasing costs and postoperative pain, we developed a novel IoS mobile health application, NeuroPath. The objective of this innovative app is to integrate enhanced recovery after surgery (ERAS) principles, patient education, and real-time pain and activity monitoring in a home setting with unencumbered two-way communication.

Methods: The NeuroPath application was built over 18 months, with support from Apple, Medable, the Department of Information-Technology and the Department of Neurosurgery.

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Objective: Although it is known that intersurgeon variability in offering elective surgery can have major consequences for patient morbidity and healthcare spending, data addressing variability within neurosurgery are scarce. The authors performed a prospective peer review study of randomly selected neurosurgery cases in order to assess the extent of consensus regarding the decision to offer elective surgery among attending neurosurgeons across one large academic institution.

Methods: All consecutive patients who had undergone standard inpatient surgical interventions of 1 of 4 types (craniotomy for tumor [CFT], nonacute redo CFT, first-time spine surgery with/without instrumentation, and nonacute redo spine surgery with/without instrumentation) during the period 2015-2017 were retrospectively enrolled (n = 9156 patient surgeries, n = 80 randomly selected individual cases, n = 20 index cases of each type randomly selected for review).

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Background/objective: In November 2014, our Neurointensive Care Unit began a multi-phased progressive early mobilization initiative for patients with subarachnoid hemorrhage and an external ventricular drain (EVD). Our goal was to transition from a culture of complete bed rest (Phase 0) to a physical and occupational therapy (PT/OT)-guided mobilization protocol (Phase I), and ultimately to a nurse-driven mobilization protocol (Phase II). We hypothesized that nurses could mobilize patients as safely as an exclusively PT/OT-guided approach.

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