Publications by authors named "Zafer Khan"
Objective: To determine whether high-flow nasal oxygen (HFNO) or noninvasive ventilator (NIV) can avoid invasive mechanical ventilation (IMV) in COVID-19-related acute respiratory distress syndrome (ADRS), and the outcome predictors of these modalities.
Design: Multicenter retrospective study conducted in 12 ICUs in Pune, India.
Patients: Patients with COVID-19 pneumonia who had PaO/FiO ratio <150 and were treated with HFNO and/or NIV.
Article Synopsis
- The study focuses on the increase in cases of COVID-19 associated mucormycosis (CAM) during the second wave of COVID-19 in India, mainly affecting patients with diabetes.
- Conducted at Noble Hospital in Pune between April 2020 and August 2021, the research involved 59 CAM patients, revealing high mortality rates linked to factors like uncontrolled diabetes and high COVID-19 CT severity scores.
- Treatment success was achieved through surgical debridement and antifungal therapy, with 74.6% of patients recovering, highlighting the urgent need for appropriate steroid use in COVID-19 treatment to prevent complications like CAM.
Cytokine release syndrome (CRS) or cytokine storm is thought to be the cause of inflammatory lung damage, worsening pneumonia and death in patients with COVID-19. Steroids (Methylprednislone or Dexamethasone) and Tocilizumab (TCZ), an interleukin-6 receptor antagonist, are approved for treatment of CRS in India. The aim of this study was to evaluate the efficacy and safety of combination therapy of TCZ and steroid in COVID-19 associated CRS.
View Article and Find Full Text PDFIndia has the second largest COVID-19 epidemic in the world as per current estimates. Central and peripheral nervous system involvement in COVID-19 (Neuro COVID-19) has been increasingly identified and reported. This letter is the first report of the spectrum of neurological disorders observed in patients with severe COVID-19 from a resource limited setting like India.
View Article and Find Full Text PDFIntroduction: Hypertension is one of the major public health challenges worldwide. Angiotensin receptor blockers (ARBs) and Calcium channel blockers (CCBs) are among the first line antihypertensive drugs. However, optimal treatment strategies in mild to moderate hypertensives who failed to achieve blood pressure (BP) control with low-dose mono-therapy are not well established.
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