Publications by authors named "Zafer Cırak"
Objective: It was targeted to assess the efficacy of certolizumab on pancreas and target organs via biochemical parameters and histopathologic scores in experimental acute pancreatitis (AP).
Materials And Methods: Forty male Sprague Dawley rats were divided into the following 5 equal groups: group 1 (sham group), group 2 (AP group), group 3 (AP + low-dose certolizumab group), group 4 (AP + high-dose certolizumab group), and group 5 (placebo group). Rats in all groups were sacrificed 24 hours after the last injection and amylase, tumor necrosis factor α, transforming growth factor β, interleukin 1β, malondialdehyde, superoxide dismutase, and glutathione peroxidase levels were studied in blood samples.
Efficacy of Agmatine Treatment in Experimental Acute Pancreatitis Rat Model.
Turk J Gastroenterol
January 2024
Background/aims: Acute pancreatitis which is characterized by pancreatic inflammation can sometimes be difficult to treat because of limited therapeutic options. The purpose of the study was to assess the effects of agmatine in the acute pancreatitis experimental rat model.
Materials And Methods: An acute pancreatitis model was created with the administration of cerulein in 40 female Sprague-Dawley rats.
Article Synopsis
- Acute pancreatitis can range from mild symptoms to severe complications like multiorgan failure, and this study investigated the impact of Adalimumab (ADA) treatment on inflammation and cell death in a rat model of the disease.
- The experiment involved administering cerulein injections to induce acute pancreatitis, followed by two different doses of ADA, with subsequent measurements of inflammation markers and histopathological analysis.
- Results showed that both doses of ADA reduced inflammation markers and apoptosis, with high-dose ADA (20 mg/kg) providing significant improvements in symptoms and a reduction in cell death, suggesting its potential use as a treatment for acute pancreatitis in humans.
Background: The aim of the study was to evaluate whether a new and successful treatment opportunity can be provided in acute pancreatitis and may prevent symptomatic treatments and show its effect through etiopathogenesis. Therefore, we want to investigate the efficacy of golimumab in an experimental rat model of cerulein-induced acute pancreatitis.
Methods: A total of 35 rats, including 7 rats in each group, were distributed into 5 groups (sham, acute pancreatitis, placebo, acute pancreatitis+golimumab 5 mg/kg, and acute pancreatitis+golimumab 10 mg/kg).
Article Synopsis
- The study aimed to assess the effectiveness of trimetazidine as a preventive treatment in a rat model of chronic pancreatitis, achieved through caerulein and alcohol administration.
- 40 female Sprague Dawley rats were divided into five groups, including a chronic pancreatitis group and groups receiving different doses of trimetazidine, with various tests conducted after 24 hours post-injection to analyze biochemical and histopathological parameters.
- Results showed that both low and high doses of trimetazidine improved biochemical markers compared to the chronic pancreatitis group, with high-dose trimetazidine also showing significant improvements in histopathological scores, highlighting its potential as a preventive treatment in chronic pancreatitis.