A Rare Complication of Cardiac Ablation: Atrial-esophageal Fistula Presenting as Odynophagia.

Radiofrequency catheter ablation has been commonly used for the treatment of drug-refractory atrial fibrillation. The esophageal injury along with the development of atrial-esophageal fistula (AE fistula) is fairly rare but is a devastating complication of catheter ablation. Described in 2004 for the first time, it is the most lethal of all the complications of catheter ablation with a high mortality rate.

Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies.

Over-expression of thymidine phosphorylase (TP) plays a key role in many pathological complications, including angiogenesis which leads to cancer cells proliferation. Thus in search of new anticancer agents, a series of 4-hydroxybenzohydrazides (1-29) was synthesized, and evaluated for in vitro thymidine phosphorylase inhibitory activity. Twenty compounds 1-3, 6-14, 16, 19, 22-24, and 27-29 showed potent to weak TP inhibitory activities with IC50 values in the range of 6.

Impact of time of arrival in emergency unit on estimation of injuries and overall care of trauma victims.

Background: Outcomes of trauma victims largely depends upon available resources, not only in terms of location of high level trauma center near the area where incident takes place but also on staff and equipment available at that particular center at that particular time. This study used retrospective charts review to ascertain whether trauma patients presenting during the night time would have delayed in establishing injuries after necessary investigations and higher in-hospital mortality than those trauma patients arriving during the day time at our hospital.

Methods: This was a cross sectional study, conducted in department of Surgery, Aga Khan University Hospital, Karachi.

Correction: UO -mediated ring contraction of pyrihexaphyrin: synthesis of a contracted expanded porphyrin-uranyl complex.

[This corrects the article DOI: 10.1039/C9SC01593K.].

Influence of different jaw positions on dynamic balance using Y-balance test.

Background: Jaw sensory-motor system has been shown to affect static balance of the body. It would be interesting to know whether it can influence dynamic balance as well. The objective of this study is to examine the influence of different jaw positions on dynamic balance using the Y-balance test.

A titanic drug resistance threat in Cryptococcus neoformans.

Increasing resistance to frontline antifungals is a growing threat to global health. In the face of high rates of relapse for patients with cryptococcal meningitis and frequent drug resistance in clinical isolates, recent insights into Cryptococcus neoformans morphogenesis and genome plasticity take on new and urgent meaning. Here we review the state of the understanding of mechanisms of drug resistance in the context of host-relevant changes in Cryptococcus morphology and cell ploidy.

Cancer nanomedicine: focus on recent developments and self-assembled peptide nanocarriers.

The applications of nanoparticulate drug delivery have received abundant interest in the field of cancer diagnosis and treatment. By virtue of their unique features and design, nanomedicines have made remarkable progress in eliminating dreadful tumors. Research in cancer nanomedicine has spanned multitudes of drug delivery systems that possess high tumor targeting ability, sensitivity towards tumor microenvironments and improved efficacy.

Neuroendocrine Tumor: A Rare, Aggressive Tumor of the Gallbladder.

We report a case of rare and aggressive gallbladder neuroendocrine carcinoma (GB-NEC), diagnosed with the help of endoscopic ultrasound (EUS). A 65-year-old asymptomatic male, with a past medical history of hypertension, underwent abdominal ultrasound for the screening of an abdominal aortic aneurysm. He was found to have a mixed echogenicity area near the stomach, an incidental finding on abdominal ultrasound.

SiCloneFit: Bayesian inference of population structure, genotype, and phylogeny of tumor clones from single-cell genome sequencing data.

Accumulation and selection of somatic mutations in a Darwinian framework result in intra-tumor heterogeneity (ITH) that poses significant challenges to the diagnosis and clinical therapy of cancer. Identification of the tumor cell populations (clones) and reconstruction of their evolutionary relationship can elucidate this heterogeneity. Recently developed single-cell DNA sequencing (SCS) technologies promise to resolve ITH to a single-cell level.

In-Plane Thorium(IV), Uranium(IV), and Neptunium(IV) Expanded Porphyrin Complexes.

Here we report the first series of in-plane thorium(IV), uranium(IV), and neptunium(IV) expanded porphyrin complexes. These actinide (An) complexes were synthesized using a hexa-aza porphyrin analogue, termed dipyriamethyrin, and the nonaqueous An(IV) precursors, ThCl(DME), UCl, and NpCl(DME). The molecular and electronic structures of the ligand, each An(IV) complex, and a corresponding uranyl(VI) complex were characterized using nuclear magnetic resonance (NMR) and UV-vis spectroscopies as well as single-crystal X-ray diffraction analysis.

Automated Detection of Radiology Reports that Require Follow-up Imaging Using Natural Language Processing Feature Engineering and Machine Learning Classification.

While radiologists regularly issue follow-up recommendations, our preliminary research has shown that anywhere from 35 to 50% of patients who receive follow-up recommendations for findings of possible cancer on abdominopelvic imaging do not return for follow-up. As such, they remain at risk for adverse outcomes related to missed or delayed cancer diagnosis. In this study, we develop an algorithm to automatically detect free text radiology reports that have a follow-up recommendation using natural language processing (NLP) techniques and machine learning models.

Effect of Different Body Postures on the Severity of Stuttering in Young Adults with Developmental Stuttering.

Objective: The current study aimed to investigate the effects of body position on the level and severity of stuttering in young adults with developmental stuttering.

Methods: A total of 24 subjects (male: 17; female: 7; mean age: 24.9 ± 6.

Automated Organ-Level Classification of Free-Text Pathology Reports to Support a Radiology Follow-up Tracking Engine.

Purpose: To evaluate the performance of machine learning algorithms on organ-level classification of semistructured pathology reports, to incorporate surgical pathology monitoring into an automated imaging recommendation follow-up engine.

Materials And Methods: This retrospective study included 2013 pathology reports from patients who underwent abdominal imaging at a large tertiary care center between 2012 and 2018. The reports were labeled by two annotators as relevant to four abdominal organs: liver, kidneys, pancreas and/or adrenal glands, or none.

Microwave-Assisted Organic Synthesis, structure-activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors.

A series of benzamide derivatives 1-12 with various functional groups (-H, -Br, -F, -OCH, -OCH, and -NO) was synthesized using an economic, and facile Microwave-Assisted Organic Synthesis, and evaluated for acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE) activity in vitro. Structure-activity relationship showed that the substitution of -Br group influenced the inhibitory activity against BCHE enzyme. Synthesized compounds were found to be selective inhibitors of BCHE.

Prevalence of Work-related Musculoskeletal Disorders among Dental Students of King Saud University, Riyadh, Kingdom of Saudi Arabia.

Aim: To evaluate the presence of work-related musculoskeletal disorders (WRMSDs) among undergraduate dental students of the College of Dentistry, King Saud University (KSU), Riyadh, Saudi Arabia.

Materials And Methods: A questionnaire-based cross-sectional survey was conducted in 2017 and distributed to150 undergraduate female, and male dental students of KSU who had started to work with patients in the clinic or with manikins. Data were collected related to WRMSDs.

UO -mediated ring contraction of pyrihexaphyrin: synthesis of a contracted expanded porphyrin-uranyl complex.

A new mixed hexaphyrin, pyrihexaphyrin (0.1.0.

Evaluation of a Strain Isolated from Honeybee Gut as a Potential Live Oral Vaccine Against Lethal Infection of Typhimurium.

In this research, species were isolated from the animal, insect and human enteric sources in Faisalabad, Punjab, Pakistan. These species were characterized by different microbiological and molecular techniques including polymerase chain reaction (PCR) by amplification of the 16S rRNA gene. Furthermore, sequencing of the amplicons confirmed all ten isolates as strains.

Porphyrinoid f-Element Complexes.

Porphyrin and related pyrrole-containing macrocycles, collectively porphyrinoids, are versatile ligands that allow access to a multitude of coordination modes. Judicious modification of the porphyrin core as well as the pendant substituents has extended the coordination chemistry of porphyrinoids to include systems that are able to stabilize f-block element complexes with possible utility. This review focuses on our group's efforts to prepare expanded porphyrin and porphyrinogen ligands that can serve as tools to study and apply f-element metal coordination chemistry: it covers the background of the topic, selected syntheses, and application of these species in the chemical and medical sciences.

Toward Complete Structured Information Extraction from Radiology Reports Using Machine Learning.

Unstructured and semi-structured radiology reports represent an underutilized trove of information for machine learning (ML)-based clinical informatics applications, including abnormality tracking systems, research cohort identification, point-of-care summarization, semi-automated report writing, and as a source of weak data labels for training image processing systems. Clinical ML systems must be interpretable to ensure user trust. To create interpretable models applicable to all of these tasks, we can build general-purpose systems which extract all relevant human-level assertions or "facts" documented in reports; identifying these facts is an information extraction (IE) task.

Assessment of Knowledge about Dental Ergonomics among Dental Students of King Saud University, Riyadh, Kingdom of Saudi Arabia.

Aim: To assess the knowledge about dental ergonomics and work-related musculoskeletal disorders (WRMSDs) among dental students of King Saud University (KSU), Riyadh, Kingdom of Saudi Arabia, undergoing practical clinical training.

Materials And Methods: A self-designed questionnaire after pre-testing was distributed to 150 dental students of KSU undergoing clinical training, to collect data related to (a) basic knowledge about dental ergonomics; (b) any course/workshop about dental ergonomics attended; (c) basic knowledge about WRMSDs; (d) familiarity about preventive measures to decrease the risk of WRMSDs; and (e) knowledge about treatment options for WRMSDs.

Results: One hundred forty-two students (95%) returned the completed questionnaires, of them 54 (38%) were males and 88 (62%) were females.

Hepaotoprotective and nephroprotective activities of Pistacia integerrima fruit extract in paracetamol intoxicated male rabbits with effect on blood cells count.

The beneficial effects of Pistacia integerrima (PI) fruit methanol extract on some liver and kidney related parameters and blood cells count of paracetamol (PCM) intoxicated male rabbits were studied. Paracetamol intoxication caused remarkable increase in the serum ALT, AST and ALP levels. The PCM intoxicated rabbits that received PI extract orally at doses of 200 mg and 400 mg/kg b.