Celecoxib Suppresses NF-κB p65 (RelA) and TNFα Expression Signaling in Glioblastoma.

Background: Glioblastoma (GBM) harbors significant genetic heterogeneity, high infiltrative capacity, and patterns of relapse following many therapies. The expression of nuclear factor kappa-B (NF-κB p65 (RelA)) and signaling pathways is constitutively activated in GBM through inflammatory stimulation such as tumor necrosis factor-alpha (TNFα), cell invasion, motility, abnormal physiological stimuli, and inducible chemoresistance. However, the underlying anti-tumor and anti-proliferative mechanisms of NF-κB p65 (RelA) and TNFα are still poorly defined.

Alleviation of banded leaf and sheath blight disease incidence in maize by bacterial volatile organic compounds and molecular docking of targeted inhibitors in .

(RS) is a pathogenic fungus that affects maize ( L.) plants and causes banded leaf and sheath blight (BLSB) with severe consequences leading to significant economic losses. Contrarily, rhizobacteria produce numerous volatile organic compounds (VOCs) that help in devising the environment-friendly mechanism for promoting plant growth and stress alleviation without having physical contact with plants.

Zinc oxide nanoparticles mediated biostimulant impact on cadmium detoxification and in silico analysis of zinc oxide-cadmium networks in Zea mays L. regulome.

Cadmium (Cd) toxicity can significantly limit plant growth and development. To eliminate the toxic effects of Cd stress, we intended to evaluate the biochemical mediated physiological responses in maize treated with biostimulant and zinc oxide nanoparticles (ZnPs). In silico analysis exhibited that the maize treated with Cd stress (200 μM) had an adverse impact on CAT1, CAT2, CAT3 and gor1 proteins, which are influential in managing the machinery of redox homeostasis.

Titanium Oxide and Zinc Oxide Nanoparticles in Combination with Cadmium Tolerant Ameliorates the Cadmium Toxicity in Maize.

The efficiency of Cd-tolerant plant growth-promoting bacteria (PGPB), zinc oxide nanoparticles (ZnO NPs), and titanium dioxide nanoparticles (TiO) in maize growing in Cd-rich conditions was tested in the current study. The best Cd-tolerant strain, , exhibited plant growth stimulation in vivo and in vitro experiments. We determined the toxic concentrations (30 (ppm)) of both NPs for plant growth.

An Insight into the Role of E2F1 in Breast Cancer Progression, Drug Resistance, and Metastasis.

Aims: This study aimed to investigate the role of E2F1 in breast cancer biology.

Background: Expression of E2F1, a transcription factor of many oncogenes and tumor suppressor genes, is lowered in several malignancies, including breast carcinoma.

Objectives: In the present study, we analyzed the status of E2F1 expression in association with diverse attributes of breast malignancy and its impact on cancer progression.

Co application of biofertilizer and zinc oxide nanoparticles upregulate protective mechanism culminating improved arsenic resistance in maize.

During this study, the bioremediation potential of zinc-oxide nanoparticles (ZnO-NPs) and PGPR mixed biofertilizer (BF) on maize plants under induced arsenic (As) stress of 50 ppm and 100 ppm was investigated. The treated plants showed increased As resistance to mitigate the adverse effects of stress by enhancing fresh and dry biomass, relative water content, protein content, soluble sugars, proline content, enzymatic antioxidant defense mechanisms including activities of catalase (CAT), peroxidase (POD), ascorbate peroxidase (APX), superoxide dismutase (SOD), and malondialdehyde (MDA) content. In the pot experiment, the parameters studied have shown that the integrated treatments of ZnO-NPs and BF cause a notable enhancement in relative water content 43%-50% and plant biomass.